Allele News and Research

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Majority of patients who appear healthy may be at risk for cardiovascular disease

Three separate studies announced today at the American Society of Hypertension Inc.'s 25th Annual Scientific Meeting and Exposition (ASH 2010) examined the cardiovascular consequences of relatively healthy patients - those who were asymptomatic and not classified as hypertensive or diabetic - and found that many patients who appear healthy may still be at risk for cardiovascular disease.

3 May 2010

Environmental factors may play bigger role in tumor development: BIDMC study

It is an accepted fact that genetics play a key role in a person's susceptibility to cancer, and that throughout life, mutations can cause damage to tumor suppressor genes further increasing the chances of developing cancerous tumors.

24 Apr 2010

Research findings may help personalize use of statins, scientists say

Researchers at NewYork-Presbyterian Hospital/Weill Cornell Medical Center have discovered why statins -- popular drugs that lower cholesterol and appear to protect against colorectal cancer development -- work for some people, but not for all.

22 Apr 2010

Obesity related FTO gene linked to Alzheimer’s disease.

If you are an American of European origin and carry the FTO gene which causes obesity, you have a much higher risk of developing Alzheimer’s disease. A recent study conducted at the University of California, Los Angeles claimed that 'A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in healthy elderly'.

21 Apr 2010

Affymetrix introduces new service for obtaining allele-specific copy number data from FFPE samples

Affymetrix, Inc. today announced the launch of the Affymetrix® MIP Copy Number Service, designed for cancer researchers using challenging FFPE samples. With the MIP Copy Number Service, scientists can now obtain high-quality allele-specific copy number data from FFPE samples. The service is available for research use only exclusively through the Affymetrix® Research Services Laboratory (ARSL).

20 Apr 2010

Study identifies protective relationship between gene variant and cognitive function in older people

New research shows a gene variant may help protect the memory and thinking skills of older people. The research will be published in the April 20, 2010, issue of Neurology, the medical journal of the American Academy of Neurology.

20 Apr 2010

FTO gene associated with loss of brain tissue: UCLA researchers

Three years ago, geneticists reported the startling discovery that nearly half of all people in the U.S. with European ancestry carry a variant of the fat mass and obesity associated gene, which causes them to gain weight - from three to seven pounds, on average - but worse, puts them at risk for obesity.

20 Apr 2010

Gene duplications can lead to functional diversity in organisms

New information about early Native Americans' horticultural practices comes not from hieroglyphs or other artifacts, but from a suite of four gene duplicates found in wild and domesticated sunflowers.

5 Apr 2010

Anesthesia can increase behavioral changes, risk of developing Alzheimer's disease

The use of repetitive anesthesia with isoflurane (one of the most common anesthetics by inhalation) increases the risk of developing changes similar to those observed in AD brains in mice with mutations of the amyloid precursor protein (APP). This is the main conclusion of Spanish researchers coordinated by Doctors Maria -ngeles Mena and Justo Garc-a de Y-benes, from CIBERNED (Centro de Investigaci-n Biom-dica en Red de Enfermedades Neurodegenerativas).

25 Mar 2010

Mayo Clinic co-led research finds first gene linked to lung cancer in "never smokers"

A five-center collaborative study that scanned the genomes of thousands of "never smokers" diagnosed with lung cancer as well as healthy never smokers has found a gene they say could be responsible for a significant number of those cancers.

22 Mar 2010

Three researchers to be honored with SBS Award for achievement in biomolecular sciences and lead discovery

The Society for Biomolecular Sciences will honor three researchers for their substantial contributions to the field of drug discovery. Each recipient will accept their award and speak at the SBS 16th Annual Conference & Exhibition in Phoenix, Arizona, April 11-15, 2010.

9 Mar 2010

Study results of new PCR technology that reports mutations associated with FXS announced

Asuragen, Inc. announced today the results of a collaborative study with scientists at the M.I.N.D. Institute at the University of California Davis evaluating a new PCR technology that reproducibly reports mutations associated with Fragile X syndrome (FXS).

2 Mar 2010

Genetic factors influence likelihood of developing PTSD

The 1994 genocide in Rwanda resulted in the mass killing of up to one million people over the course of about 100 days. Although the exact death toll is unknown, experts estimate that as much as 20% of the country's entire population was murdered. There can be no doubt or surprise then that some of the survivors developed posttraumatic stress disorder, or PTSD, an anxiety disorder that can develop after witnessing or experiencing a traumatizing event, such as abuse, war, or natural disaster.

26 Feb 2010

Emerging concepts from gene regulation studies in immune cells

The seventh meeting in the “Emergence and Convergence” series jointly organized by La Fondation IPSEN and Nature brings together today in San Antonio (Texas, USA) leading experts to discuss concepts emerging from gene regulation studies in immune cells that have led to insights into the initiation and maintenance of epigenetic chromatin marks necessary for proper differentiation and function of these cells in the immune system.

19 Feb 2010

Study: Multiple genetic markers linked with CVD not associated with improvement in CVD risk prediction

Creation of a genetic risk score comprised of multiple genetic markers associated with cardiovascular disease (CVD) was not associated with significant improvement in CVD risk prediction in a study that included more than 19,000 women, according to a study in the February 17 issue of JAMA.

17 Feb 2010

Allele-specific DNA methylation a widespread phenomenon, reveals IoP study

Researchers from the Institute of Psychiatry (IoP), King's College London, have identified numerous novel regions of the genome where the chemical modifications involved in controlling gene expression are influenced by either genetic variation or the parental origin of that particular stretch of DNA. This contradicts previous assumptions that epigenetic signals are generally equal across both copies of a given region of the genome, except at a small number of known imprinted genes.

15 Feb 2010

Study validates Transgenomic's COLD-PCR technology for colorectal tumor-associated KRAS mutation detection

Transgenomic, Inc. announced today that it has completed a preliminary study with a leading pharmaceutical company that validates the use of its licensed COLD-PCR technology to detect colorectal tumor-associated KRAS mutations that determine efficacy of recently developed therapies. These were detected in plasma samples in which the mutation levels were too low for detection by standard DNA analysis methodologies such as Sanger sequencing.

9 Feb 2010

Study may lead to preventative and therapeutic treatments for MS patients

Previous studies have shown multiple sclerosis (MS) patients are more often born in spring than in any other season, indicating that there is an environmental risk factor for the disease. A paper in the journal Neurology, reviewed for f1000 Medicine by Emmanuelle Waubant and Ellen Mowry, now suggests that this seasonal effect is mediated by the gene HLA-DRB1.

30 Jan 2010

Rubicon Genomics reaches agreement with ZyGEM to market its PicoPlex single-cell amplification kits

Rubicon Genomics, Inc., a developer of pre-analytical amplification products that enable more comprehensive genetic analysis of clinical and research samples, announced today that it has reached agreement with ZyGEM to non-exclusively market Rubicon's PicoPlex™ single-cell amplification kits in Australia and New Zealand.

30 Jan 2010

Humans' evolutionary advantage also makes them susceptible to cancer, dementia and heart disease

The same evolutionary genetic advantages that have helped increase human lifespans also make us uniquely susceptible to diseases of aging such as cancer, heart disease and dementia, reveals a study to be published in a special PNAS collection on "Evolution in Health and Medicine" on Tuesday, Jan. 26.

28 Jan 2010

Allele News and Research

Majority of patients who appear healthy may be at risk for cardiovascular disease

Environmental factors may play bigger role in tumor development: BIDMC study

Research findings may help personalize use of statins, scientists say

Obesity related FTO gene linked to Alzheimer’s disease.

Affymetrix introduces new service for obtaining allele-specific copy number data from FFPE samples

Study identifies protective relationship between gene variant and cognitive function in older people

FTO gene associated with loss of brain tissue: UCLA researchers

Gene duplications can lead to functional diversity in organisms

Anesthesia can increase behavioral changes, risk of developing Alzheimer's disease

Mayo Clinic co-led research finds first gene linked to lung cancer in "never smokers"

Three researchers to be honored with SBS Award for achievement in biomolecular sciences and lead discovery

Study results of new PCR technology that reports mutations associated with FXS announced

Genetic factors influence likelihood of developing PTSD

Emerging concepts from gene regulation studies in immune cells

Study: Multiple genetic markers linked with CVD not associated with improvement in CVD risk prediction

Allele-specific DNA methylation a widespread phenomenon, reveals IoP study

Study validates Transgenomic's COLD-PCR technology for colorectal tumor-associated KRAS mutation detection

Study may lead to preventative and therapeutic treatments for MS patients

Rubicon Genomics reaches agreement with ZyGEM to market its PicoPlex single-cell amplification kits

Humans' evolutionary advantage also makes them susceptible to cancer, dementia and heart disease

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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