Amyloid Plaque News and Research

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Scientists characterize Alzheimer's neurotoxin structure - potential new treatment approaches

Amyloid plaques, the hallmark of Alzheimer's disease, are clumps of fiber-like misfolded proteins which many experts think cause this devastating neurodegenerative disease.

4 Dec 2007

New drug may restore memory with Alzheimer's disease

A 2006 study by MetLife found that adults over age 55 fear Alzheimer's disease more than cancer, and with good reason. Alzheimer's creeps up on patients and their families, robbing more than half of all Americans over age 85 of their memory and ability to care for themselves.

14 Nov 2007

Aggregation propensity, amyloid peptide toxicity and Alzheimer disease

Cells have evolved multiple mechanisms to ensure proper folding, but a number of molecular and biophysical events - such as changes in pH or temperature, mutations, and oxidation - can disrupt a protein's native shape.

31 Oct 2007

Cautious optimism for new Alzheimer's medications

Alzheimer's disease takes a long time to develop, which suggests that it may be possible to design drugs that work early in the disease process, to delay the start of symptoms.

10 Oct 2007

Vaccine suppresses aggregates of tau protein - implications for Alzheimer's

A new study by NYU Medical Center researchers shows for the first time that the immune system can combat the pathological form of tau protein, a key protein implicated in Alzheimer's disease.

22 Aug 2007

Scientists take plumber's approach to Alzheimer's

Scientists are trying a plumber's approach to rid the brain of the amyloid buildup that plagues Alzheimer's patients: Simply drain the toxic protein away.

13 Aug 2007

Experimental Alzheimer's drug begins clinical trials

A drug based on the design of a Purdue University researcher to treat Alzheimer's disease began the first phase of human clinical trials this week.

23 Jun 2007

Stress and Alzheimer's disease

Subjecting mice to repeated emotional stress, the kind we experience in everyday life, may contribute to the accumulation of neurofibrillary tangles, one of the hallmarks of Alzheimer's disease, report researchers at the Salk Institute for Biological Studies.

17 Jun 2007

Breakdown of myelin may be the cause of Huntington's disease

Last month, Dr. George Bartzokis, director of the UCLA Memory Disorders and Alzheimer's Disease Clinic, suggested in the journal Alzheimer's & Dementia that the breakdown of a type of myelin that develops late in life promotes the buildup of toxic amyloid plaques long associated with Alzheimer's disease.

16 Jun 2007

Mild cognitive disorder often an early symptom of Alzheimer's disease

Using new MRI techniques to analyze tissue composition and structure in the brain, researchers from the University of Pennsylvania School of Medicine and the National Institute on Aging successfully detected mild cognitive disorder (MCI), a condition in which patients suffer mild memory problems and is often an early symptom of Alzheimer's disease (AD).

14 Jun 2007

Myelin and Huntington's disease

14 Jun 2007

Strokes role in Alzheimer's disease

Researchers have discovered key details of how stroke or traumatic brain injury can trigger Alzheimer's disease (AD) by enhancing formation of brain-clogging amyloid plaques.

8 Jun 2007

What causes Alzheimer's disease?

Researchers tied the accumulation of the toxic brain protein beta-amyloid to Alzheimer's disease, according to a study reported at the 54th Annual Meeting of SNM, the world's largest society for molecular imaging and nuclear medicine professionals.

5 Jun 2007

Brain inflammation may actually be a friend for Alzheimer's patients

Inflammation in the brain may not be so bad after all when it comes to Alzheimer's disease.

3 Jun 2007

New hypothesis on Alzheimer's disease

Researchers at Rensselaer Polytechnic Institute are challenging current thinking on the causes and prevention of Alzheimer's disease, offering a new hypothesis that could be the key to preventing this form of dementia.

30 May 2007

Immune antibodies penetrate neurons to clear Alzheimer's-linked amyloid

Researchers at Weill Cornell Medical College have gotten much closer to understanding how immune-based therapies can treat Alzheimer's disease -- by studying how antibodies go inside brain cells to reduce levels of Alzheimer's-linked amyloid peptides that form plaques between neurons.

24 May 2007