Amyotrophic Lateral Sclerosis News and Research

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Phase II clinical trial evaluates the safety and efficacy of a Muse cell-based product in patients with ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of motor functions, which eventually leads to death within 5 years of its onset.

1 Feb 2024

Hot spring baths shown to boost gut health, study finds

Researchers discovered that bathing in Japanese hot springs significantly alters the gut microbiota in healthy individuals, offering potential health benefits by increasing certain beneficial bacteria. This is the first study to explore the distinct effects of different hot spring types on the gut microbiome.

30 Jan 2024

Weill Cornell Medicine researcher wins $2.1 million grant to study repetitive DNA and RNA sequences

Dr. Jeannine Gerhardt, an assistant professor of stem cell biology in obstetrics and gynecology and in reproductive medicine at Weill Cornell Medicine, has received a five-year, $2.1 million grant from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health, for the study of repetitive DNA and RNA sequences and the mechanisms by which they cause cell dysfunction and diseases.

30 Jan 2024

European consortium awarded €6.5M to study psychedelic-assisted therapy

A European consortium of 19 partners has been awarded over €6.5M by the European Union to study psilocybin to treat psychological distress in people with progressive incurable illnesses requiring palliative care.

24 Jan 2024

Discovery of toxic and protective short RNAs associated with Alzheimer's disease and superior memory capacity

Researchers explored how Death Induced by Survival gene Elimination through the analysis of RNA-induced silencing complex-bound short RNAs in Alzheimer's disease models influences neuronal survival and correlates with neurotoxicity in AD.

22 Jan 2024

Plant protein in midlife boosts chances of healthy aging, study finds

A study in The American Journal of Clinical Nutrition reveals that higher dietary protein intake, especially plant protein, in middle adulthood significantly increases the likelihood of healthy aging, reducing chronic diseases and improving physical and mental health.

18 Jan 2024

ALS progression linked to mitochondria-associated membrane-ER disconnection

Researchers at Nagoya University in Japan have discovered a relationship between the progression of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the disruption of mitochondria-associated membranes (MAM), the contact point between the mitochondria and the endoplasmic reticulum (ER) of the cell.

17 Jan 2024

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

In our latest interview, News-Medical speaks with Rosanna Zhang from ACROBiosystems about utilizing organoids for disease modeling in the field of neuroscience research.

From Aneuro - An ACROBiosystems Brand 11 Jan 2024

Blocking brain inflammation could slow, reverse ALS symptoms

In people with amyotrophic lateral sclerosis (ALS), changes in neurons appear to activate immune cells. Lowering the inflammation could reduce the symptoms of the disease, according to a study led by Chantelle Sephton, a professor at Université Laval's Faculty of Medicine.

10 Jan 2024

Infammasomes provide a therapeutic target against human diseases

The structure of inflammasomes and their role in diseases.

9 Jan 2024

Speech Accessibility Project expands to include ALS patients in U.S. and Puerto Rico

The Speech Accessibility Project has expanded its recruitment and is inviting U.S. and Puerto Rican adults living with amyotrophic lateral sclerosis to participate.

5 Jan 2024

Natural compounds show promise in modulating heme breakdown, offering new therapeutic avenues

Study explores the impact of natural compounds on bilirubin production and heme catabolic pathway modulation, highlighting their potential in treating neurodegenerative and cardiovascular diseases.

3 Jan 2024

Patient-specific muscle models pave way for personalized neuromuscular therapies

Scientists have so far identified around 800 different neuromuscular diseases. These conditions are caused by problems in the way muscle cells, motor neurons and peripheral cells interact.

19 Dec 2023

Cryo-EM reveals TAF15 as potential treatment target for frontotemporal dementia

An international team of researchers including experts at the Indiana University School of Medicine has identified a protein found in the brains of people with frontotemporal dementia (FTD), discovering a new target for potential treatments for the disease.

7 Dec 2023

Scientists uncover key protein aggregation in frontotemporal dementia

Most neurodegenerative diseases, including dementias, involve proteins aggregating into filaments called amyloids.

6 Dec 2023

Military personnel repeatedly exposed to blasts show increased brain inflammation and structural changes

The brains of special warfare community personnel repeatedly exposed to blasts show increased inflammation and structural changes compared with a control group, potentially increasing the risk of long-term, brain-related disease, according to a new study.

6 Dec 2023

Researchers evaluate possible mitochondrial factors in Alzheimer's pathogenesis

A group of authors critically evaluated and interpreted the evidence linking mitochondrial dysfunction and metabolic changes to the pathogenesis of Alzheimer's disease (AD).

5 Dec 2023

New insights into the interplay between prions and TDP-43 in neurodegenerative pathology

Neurodegenerative diseases are characterized by the deposition of clumped proteins in the brain and progressive neuronal cell death.

4 Dec 2023

Molecular trap offers hope for ALS treatment

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects neurons in the brain and spinal cord causing loss of muscle control.

16 Nov 2023

New drug shows exciting promise for the treatment of ALS

In science, a simple but thorough observation can kick-start the most surprising findings. Researchers at the Hollings Cancer Center at the Medical University of South Carolina noticed that mice lacking a protein of interest in cancer research were showing visible signs of abnormal motor functions as they aged, including loss of coordination and strength.

8 Nov 2023