Anaphylaxis News and Research

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Anaphylaxis is an acute multi-system severe type I hypersensitivity reaction. Due in part to the variety of definitions, between 1% and 15% of the population of the United States can be considered "at risk" for having an anaphylactic reaction if they are exposed to one or more allergens. Of those people who actually experience anaphylaxis, up to 1% may die as a result.

Infants have less severe food-induced anaphylaxis unlike older children

Symptoms of food-induced anaphylaxis in infants are much less severe than in toddlers and older children, according to a study from Ann & Robert H. Lurie Children's Hospital of Chicago published in the Annals of Allergy, Asthma and Immunology.

11 Jul 2018

Merck announces FDA acceptance of supplemental Biologics License Application for KEYTRUDA

Merck, known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration has accepted for standard review a new supplemental Biologics License Application for KEYTRUDA, Merck's anti-PD-1 therapy, as adjuvant therapy in the treatment of patients with resected, high-risk stage III melanoma and granted a Prescription Drug User Fee Act, or target action, date of February 16, 2019.

25 Jun 2018

Most adults with allergies do not use prescribed epinephrine even in emergency situations

The most effective, life-saving treatment for a severe allergic reaction is epinephrine. Yet a new study shows in an emergency, 52 percent of adults with potentially life-threatening allergies didn't use the epinephrine auto-injectors they were prescribed.

21 Jun 2018

Men's Health Week

A series of articles for Men's Health Week 2018.

11 Jun 2018

FDA approves first Neulasta biosimilar to help decrease infection risk during cancer treatment

The U.S. Food and Drug Administration today approved Fulphila (pegfilgrastim-jmdb) as the first biosimilar to Neulasta (pegfilgrastim) to decrease the chance of infection as suggested by febrile neutropenia (fever, often with other signs of infection, associated with an abnormally low number of infection-fighting white blood cells), in patients with non-myeloid (non-bone marrow) cancer who are receiving myelosuppressive chemotherapy that has a clinically significant incidence of febrile neutropenia.

4 Jun 2018

FDA approves novel enzyme therapy for adults with rare and serious genetic disease

The U.S. Food and Drug Administration today approved Palynziq (pegvaliase-pqpz) for adults with a rare and serious genetic disease known as phenylketonuria (PKU).

25 May 2018

Scientists reveal active role of IgG antibodies in severity of anaphylaxis

The most severe allergic reaction, anaphylaxis, is the result of an inappropriate immune reaction following the introduction of a usually harmless antigen into the body.

16 May 2018

First Aid Article Series

A series of articles on First Aid for all ages.

4 May 2018

Acid-suppressing medicines and antibiotics in infancy linked to later allergic disease risk

The use of acid-suppressing medications or antibiotics in the first 6 months of infancy was associated with an increased risk for the subsequent development of allergic diseases in childhood.

2 Apr 2018

New study identifies possible target for treatment of dangerous allergic reactions

Prospects for inhibiting the most dangerous symptoms of allergic reactions may be brighter with the publication of a new study that identifies a possible target for drug therapies.

23 Feb 2018

Duke researchers show how to retrain immune system of peanut-allergy mice

Treating food allergies might be a simple matter of teaching the immune system a new trick, researchers at Duke Health have found.

21 Feb 2018

Trial shows safety, feasibility of adding immunotherapy during chemoradiation for head and neck cancer

Analysis of a clinical trial, RTOG Foundation 3504, finds that nivolumab immunotherapy can be administered safely in conjunction with radiation therapy and chemotherapy for patients with newly diagnosed local-regionally advanced head and neck cancers.

13 Feb 2018

Special precautions not required when people with egg allergy take flu shots

For years, people with an egg allergy have been told to avoid or take special precautions when getting a flu shot because most influenza vaccines are grown in eggs and contain a tiny amount of egg protein. An updated practice parameter from the Joint Task Force on Practice Parameters stresses that people with egg allergy should receive their yearly flu shot, and that no special precautions are required.

19 Dec 2017

Many food-induced anaphylaxis cases in children occur under adult supervision

At least a third of reactions in children with food-induced anaphylaxis to a known allergen occur under adult supervision, according to a new study led by AllerGen researchers in Quebec, Ontario and Alberta.

14 Dec 2017

First short-acting ‘follow-on’ insulin receives FDA approval to treat diabetes

The U.S. Food and Drug Administration today approved Admelog (insulin lispro injection), a short-acting insulin indicated to improve control in blood sugar levels in adults and pediatric patients aged 3 years and older with type 1 diabetes mellitus and adults with type 2 diabetes mellitus.

12 Dec 2017

FDA grants approval to first biosimilar for treatment of patients with breast, stomach cancers

The U.S. Food and Drug Administration today approved Ogivri (trastuzumab-dkst) as a biosimilar to Herceptin (trastuzumab) for the treatment of patients with breast or metastatic stomach cancer (gastric or gastroesophageal junction adenocarcinoma) whose tumors overexpress the HER2 gene (HER2+).

4 Dec 2017

Study identifies new role for stress receptor CRF1 expressed on mast cells

A new study published online in the Journal of Leukocyte Biology provides new insight into how stress, through signaling of corticotropin-releasing factor (CRF), interacts with cells in the immune system to cause disease.

1 Dec 2017

Inexplicable cases of anaphylaxis caused by uncommon red meat allergy, study finds

While rare, some people experience recurrent episodes of anaphylaxis--a life-threatening allergic reaction that causes symptoms such as the constriction of airways and a dangerous drop in blood pressure--for which the triggers are never identified.

28 Nov 2017

Got food allergies? Add milk to the worries for your meal

Since her son Matt was an infant, Lynda Mitchell knew he had a milk allergy. She controlled the symptoms by switching his baby formula. But when he was 1, Halloween proved horrifying. While trick-or-treating in a pumpkin costume, Matt grabbed a chocolate bar and bit through the wrapper. Although he spit out the candy, his violent allergic reaction morphed into a mess of hives, swelling and labored breathing. He ended up in the emergency room.

22 Nov 2017

Mother's diet can protect nursing newborns against food allergies, research shows

Research published in the Journal of Experimental Medicine today indicates that a mother's diet can protect nursing newborns against food allergies.

20 Nov 2017