Anaphylaxis Causes

There are several known triggers or causes of anaphylactic reactions. Some of the common and identifiable causes include:-

Medications or drugs

Penicillin is the most common cause of drug-induced anaphylaxis. The incidence of allergy to penicillin is around 1 in 500 of the population. Many of these individuals may escape with just a skin rash or urticaria as a response to penicillin. Only some would manifest symptoms of an anaphylactic shock.

Around 4% of those allergic to penicillins are also allergic to cephalosporins (another group of antibiotics) especially to first generation cephalosporins. The next common group of medications that cause drug induced anaphylaxis includes nonsteroidal anti-inflammatory drugs (NSAIDs) like Aspirin.

Insect stings

Reactions to stings from bees, wasps and ants that belong to the order Hymenoptera are the second most common cause of anaphylaxis after drugs. These occur in up to 3% of the population. Reactions are often rapid and may be life threatening or fatal within 30 minutes.


There is a large variety of foods that a large population is allergic to. For example, nearly 17% are allergic to milk, 7% to eggs, 2% to peanuts and fish and 3.5% to other types of foods.

Food anaphylaxis is most common in children and young. Common food allergies among the young include those to peanuts, walnuts and pecans, shellfish, milk and eggs.

Some people are also allergic to food additives, colorants and preservative chemicals as well. Mislabeling and contamination during manufacturing or cooking may lead to inadvertent exposure and raise the risk of anaphylaxis.

Drugs used in anaesthesia

Some people are allergic to neuromuscular blocking agents or muscle relaxants used in anesthesia. Other possible anaphylaxis-causing agents used during anesthesia, imaging and surgical procedures include opioids, radiocontrast dyes, isosulphan or  methylene blue, blood products or blood transfusions, colloids, chlorhexidine and protamine.

The risk of occurrence of these events are 1 in 3500 to 1 in 20000 and 4% of these reactions may be fatal. Muscle relaxants lead to 60% of general anaesthesia related anaphylactic reactions. Suxamethonium causes the highest risk of anaphylaxis.

Exercise-induced anaphylaxis

This may be associated with previous intake of food or an allergic medication like Aspirin or an NSAID.

Idiopathic anaphylaxis

In these cases the cause is not identified.

Summation anaphylaxis

This type occurs in the presence of other diseases that use medications which again raise the risk of anaphylaxis. For example, asthma patients, those with infections, those under psychological stress, those taking alcohol and drugs such as  β- blockers, angiotensin-converting enzyme inhibitors (ACEI), NSAIDs etc.

These individuals are prone to allergies and anaphylactic shock both due to their disease condition as well as the medication that they take.

Summary of causes of anaphylaxis

  • Drugs, chemicals and biologic agents: penicillins, cephalosporins, sulphonamides, muscle relaxants, vaccines, insulin, thiamine, protamine, gamma globulin, antivenoms, formaldehyde, ethylene oxide, chlorhexidine, semen.
  • Foods: peanuts, tree nuts, shellfish, fin fish, milk, egg, fruits, vegetables, flour.
  • Hymenopteran sting venom, insect saliva, and other venoms: bees, wasps, ants, hornets, ticks, triatomid bugs, snakes, scorpions, jelly fish.
  • Latex
  • Environmental: pollen, horse dander, hydatid cyst rupture.
  • Physical factors: exercise, cold, heat.
  • Medications and biologic agents: opiates, aspirin and NSAIDs, ACEI, vancomycin, radiocontrast media, N-acetylcysteine, fluorescein.
  • Food additives: metabisulphite, tartrazine.
  • Idiopathic – no cause is known

Further Reading

Last Updated: Jun 10, 2023

Dr. Ananya Mandal

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.


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