Angiotensin Converting Enzyme 2 News and Research

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Researchers identify fusion peptide-specific monoclonal antibodies with broad neutralizing activity

Neutralizing mAbs identified in the current study sheds light on ACE2-triggered conformational change that restricts the immunogenicity of the highly conserved FP region.

14 Jul 2022

The global succinylation and protein abundance in SARS-CoV-2–infected cells

Researchers assessed the global succinylation of SARS-CoV-2-infected host cells.

14 Jul 2022

The interaction between SARS-CoV-2 and influenza A during coinfection

Researchers assessed the host response to influenza A and COVID-19 during coinfection.

14 Jul 2022

The impact of the SARS-CoV-2 spike A222V mutation on viral infection

Researchers analyzed the structural function of the genetic background of SARS-CoV-2 in the appearance and persistence of A222V spike mutation.

13 Jul 2022

Production of anti-SARS-CoV-2 antibodies from hyperimmunized chickens

A new study reports the production of neutralizing antibodies against SARS-CoV-2 in hyperimmunized hens.

12 Jul 2022

Scientists determine the binding affinity of anti-SARS-CoV-2 antibodies in response to infection or vaccination

Scientists measured the quantity and binding affinity (avidity) of antibodies against five different viral proteins.

12 Jul 2022

Stinging nettle extract inhibits SARS-CoV-2 cell fusion

In a recent study posted to the bioRxiv* preprint server, researchers at Ghent University and KU Leuven, Belgium, demonstrated that Urtica dioica agglutinin (UDA), a monomeric lectin extracted from stinging nettle rhizomes, inhibited severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) cell to cell fusion.

12 Jul 2022

SARS-CoV-2 Omicron BA.5 tropism shifting back to ancestral strains

In a recent study posted to the medRxiv* pre-print server, researchers from Australia and Switzerland gathered data to help track and manage ongoing and future infection waves by new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VOC) Omicron globally.

12 Jul 2022

Scientists investigate impact of SARS-CoV-2 RBD mutations across variants

In a recent study posted to the medRxiv* pre-print server, Australian researchers comprehensively investigated the impact of 39 receptor-binding-domain (RBD) mutations in six severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and variants of interest (VOIs).

12 Jul 2022

Persistence of SARS-CoV-2 in tissues leads to long COVID

PASC is likely the result of long-term persistence of SARS-CoV-2 in various tissues

11 Jul 2022

Study reveals sex-based differences in the clinical outcomes of COVID-19 in the US

Researchers investigated sex-based differences among COVID-19 patients in the United States.

11 Jul 2022

SARS-CoV-2 spike protein downregulates ACE2 expression

In a new study, researchers observed the downregulation of ACE2 by SARS-CoV-2.

11 Jul 2022

Study assesses the potential of plant secondary metabolites as potential anti-COVID-19 agents

A new study has focused on identifying plant secondary metabolites (PSM) having a higher affinity for S-RBD of SARS-CoV-2.

11 Jul 2022

Characterization of longer-term effects on behavior and brain inflammation following recovery from mild COVID-19

A recent study reported that long COVID in mice causes brain inflammation and cognitive impairment.

8 Jul 2022

The replicative ability and pathogenicity of Omicron BA.4 and BA.5 isolates in hamsters

Researchers characterized the clinical isolates of SARS-CoV-2 Omicron BA.4 and BA.5.

8 Jul 2022

Study suggests spironolactone may improve clinical outcomes in COVID-19

Researchers performed an integrative analysis of clinical outcomes and viral entry networks in severe COVID-19 infection.

8 Jul 2022

Nanoparticle vaccine could protect against animal viruses including future SARS-CoV-2 variants

A recent study published in the Science journal depicted that mosaic receptor-binding domain (RBD) nanoparticles immunize from diverse sarbecovirus challenges, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), among animal models.

8 Jul 2022

Discovery of multiple new SARS-CoV-2 MPro inhibitors

In a recent study posted to the bioRxiv* preprint server, researchers performed an extensive library docking for new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) covalent and non-covalent inhibitors.

8 Jul 2022

After 3 doses of COVID vaccine, most cancer patients retain detectable humoral immunity

In a recent study posted to the medRxiv* preprint server, researchers assessed the efficacy and durability of immune responses to the third dose of coronavirus disease 2019 (COVID-19) vaccines. They also assessed the efficacy of the fourth vaccine dose among severely immunocompromised patients with hematological malignancies.

7 Jul 2022

Diabetes patients on Medicare Advantage plans less likely to be prescribed newer, more expensive medicines

While patients with diabetes on Medicare Advantage plans are more likely to receive preventive treatments, they were less likely to be prescribed newer, more expensive medications and were more likely to have higher blood pressure and worse blood glucose control than patients on Medicare Fee-For-Service plans, according to a new study led by a University of Pittsburgh School of Medicine physician-scientist.

7 Jul 2022

Angiotensin Converting Enzyme 2 News and Research

Researchers identify fusion peptide-specific monoclonal antibodies with broad neutralizing activity

The global succinylation and protein abundance in SARS-CoV-2–infected cells

The interaction between SARS-CoV-2 and influenza A during coinfection

The impact of the SARS-CoV-2 spike A222V mutation on viral infection

Production of anti-SARS-CoV-2 antibodies from hyperimmunized chickens

Scientists determine the binding affinity of anti-SARS-CoV-2 antibodies in response to infection or vaccination

Stinging nettle extract inhibits SARS-CoV-2 cell fusion

SARS-CoV-2 Omicron BA.5 tropism shifting back to ancestral strains

Scientists investigate impact of SARS-CoV-2 RBD mutations across variants

Persistence of SARS-CoV-2 in tissues leads to long COVID

Study reveals sex-based differences in the clinical outcomes of COVID-19 in the US

SARS-CoV-2 spike protein downregulates ACE2 expression

Study assesses the potential of plant secondary metabolites as potential anti-COVID-19 agents

Characterization of longer-term effects on behavior and brain inflammation following recovery from mild COVID-19

The replicative ability and pathogenicity of Omicron BA.4 and BA.5 isolates in hamsters

Study suggests spironolactone may improve clinical outcomes in COVID-19

Nanoparticle vaccine could protect against animal viruses including future SARS-CoV-2 variants

Discovery of multiple new SARS-CoV-2 MPro inhibitors

After 3 doses of COVID vaccine, most cancer patients retain detectable humoral immunity

Diabetes patients on Medicare Advantage plans less likely to be prescribed newer, more expensive medicines

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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