Antidepressant News and Research

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Antidepressants are medicines that treat depression. Your doctor can prescribe them for you. They can improve your mood, sleep, appetite and concentration. It may take several weeks for them to help. There are several types of antidepressants. You and your doctor may have to try several before finding what works best for you.

Some people are more than twice as likely to become depressed as others

The paper, which has just been published in the British Journal of Psychiatry, has found more than a fifth of the population has a genetic predisposition to depression, in response to a series of stressful life events.

7 Mar 2006

SSRI use associated with increased risk for heart patients

In a surprising finding, patients with coronary artery disease who take commonly used antidepressant drugs may be at significantly higher risk of death, Duke University Medical Center researchers have found.

7 Mar 2006

Study provides new evidence of the importance of reward pathways in the brain

Deleting a specific gene in the brain has the same effect that antidepressants do in mice that have been conditioned to be depressed, report researchers at UT Southwestern Medical Center.

24 Feb 2006

Antidepressants may affect fetus

A University of California, San Diego (UCSD) School of Medicine collaborative study with Boston University's Slone Epidemiology Center found an increased risk of persistent pulmonary hypertension (PPHN) in newborns of mothers who used certain commonly prescribed antidepressants in late pregnancy.

20 Feb 2006

Panorama programme lead to significant increase in adverse paroxetine reports

The number of adverse reactions reported by UK doctors to the antidepressant paroxetine - often know by its brand name Seroxat - rose by 61 per cent after three editions of the BBC's award-winning current affairs programme Panorama explored increasing concerns about the drug.

14 Feb 2006

Gene therapy cures depressed mice

Researchers in the U.S. say that deleting a specific gene in the brain of mice that have been conditioned to be depressed, has the same effect as antidepressants.

13 Feb 2006

Stopping antidepressants during pregnancy may lead to relapse

Women who stop taking antidepressant medications during pregnancy are at a five times greater risk for recurrence of depression than are women who continue taking their medication throughout their pregnancies, according to a multi-institutional study published in the Journal of the American Medical Association.

13 Feb 2006

Use of antidepressants during pregnancy linked to neonatal abstinence syndrome in infants

Almost one-third of 60 newborn infants whose mothers took antidepressants during pregnancy experienced neonatal abstinence syndrome, a type of withdrawal with symptoms that include high-pitched crying, tremors and disturbed sleep, according to a study in the February issue of Archives of Pediatrics & Adolescent Medicine.

9 Feb 2006

Pregnancy does not provide protection against depression

Pregnancy has historically been described as a time of emotional well-being, providing "protection" against psychiatric disorder, but a new study says the hormonal changes which occur during pregnancy do not protect women from depression, and those taking antidepressants may need to continue despite concerns about fetal damage.

2 Feb 2006

Run, skip, hop, jump or just walk to lift those blues

Researchers at the University of Texas at Austin say a single 30-minute walk on a treadmill can give a temporary emotional lift to patients diagnosed with major depressive disorder.

26 Jan 2006

SSRIs most effective in treating post-traumatic stress disorder

A variety of medications can help reduce the core symptoms of post-traumatic stress disorder (PTSD) as well as reduce associated depression and disability, but selective serotonin reuptake inhibitors (SSRIs) should be considered as first line agents as there is most evidence showing that these can be effective.

25 Jan 2006

Bristol-Myers Squibb agrees to record securities litigation settlement with sweeping drug disclosure requirements announces Labaton Sucharow

After prosecuting the securities litigation claims against Bristol-Myers Squibb Co. (BMS) for over five years, Labaton Sucharow, Lead Counsel representing the class and Lead Plaintiff, the LongView Collective Investment Fund of the Amalgamated Bank, reached an agreement in principle to settle the claims for $185 million in addition to meaningful corporate governance reforms that will affect future consumers and investors alike.

23 Jan 2006

SSRI antidepressants may also affect human immune system

Drugs that treat depression by manipulating the neurotransmitter serotonin in the brain may also affect the user's immune system in ways that are not yet understood, say scientists from Georgetown University Medical Center and a Canadian research institute.

23 Jan 2006

Drugs and electroconvulsive therapy best treatment for severe depression

According to a new study, despite the fact that over the last decade, two treatments which are often castigated in the media, and have raised both public and professional concern, antidepressants such as Prozac and Seroxat, and electroconvulsive therapy (ECT), remain the most effective treatments for moderate to severe depression.

16 Jan 2006

New research reveals a protein involved in lifting depression

Paul Greengard, Ph.D.,a Nobel Laureate researcher says that mice deficient in a protein, called p11, display depression-like behaviours, while those with sufficient amounts behave as if they have been treated with antidepressants.

9 Jan 2006

Suicide risk drops with antidepressants

According to a new study the risk of suicide is not increased when adults start using antidepressants, and does in fact drop almost as soon as medication is begun.

2 Jan 2006

Common gene variation lessens Tamoxifen’s benefit

Researchers have discovered that one of the most commonly prescribed drugs for breast cancer, tamoxifen, may not be as effective for women who inherit a common genetic variation.

19 Dec 2005

Depression treatment in children - poor data

When the U.S. Food and Drug Administration declared in 2004 that certain antidepressants are linked to an increased risk of suicide in adolescents, there was surprisingly little data about how depression was being treated in young patients.

28 Nov 2005

Adverts for SSRI antidepressants misleading

Consumer ads for a class of antidepressants called SSRIs often claim that depression is due to a chemical imbalance in the brain, and that SSRIs correct this imbalance, but these claims are not supported by scientific evidence, say researchers in PLoS Medicine.

13 Nov 2005

New York-Presbyterian Hospital offers Vagus Nerve Stimulation (VNS) Therapy

New York-Presbyterian Hospital/Columbia University Medical Center is the first in the greater New York City-area to offer Vagus Nerve Stimulation (VNS) Therapy as a long-term treatment specifically approved by the FDA for treatment-resistant depression (TRD).

7 Nov 2005