Antiviral Drug News and Research

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Study supports value of social restrictions during influenza pandemics

Although physicians have imposed quarantine orders since at least 1374, when the Port of Venice officially isolated foreigners and shippers for 40 days to keep out infectious scourges, there has been no definitive evidence that public health measures like quarantining the sick and isolating people after exposure to ill people would save lives during an influenza pandemic.

8 Aug 2007

Biota increases damages claim against GlaxoSmithKline

Australian company Biota has filed its updated Particulars of Loss and Damage in its suit against GlaxoSmithKline (GSK) for failing to support the influenza drug, Relenza, discovered by Biota and licensed to GSK in 1990.

31 Jul 2007

Tonsil epithelial factors may influence oropharyngeal HIV transmission

Current research demonstrates that the tonsils may possess the necessary factors to act as a transmission site for the spread of HIV.

27 Jul 2007

Long-term herpes treatment may reduce HIV infectivity

Long-term anti-herpes treatment of women infected with both HIV and HSV2, the virus that causes genital herpes, may reduce the proportion of women with detectable HIV virus in their genital secretions according to the results of a trial in Tanzania presented the International AIDS Society Conference in Sydney.

26 Jul 2007

GPs antibiotic prescribing practices are still contributing to resistance

GPs are still prescribing antibiotics for up to 80% of cases of sore throat, otitis media, upper respiratory tract infections, and sinusitis, despite the fact that official guidance warns against this practice, according to an analysis of the world's largest primary care database of consultations and prescriptions, published this week in a supplement to the Journal of Antimicrobial Chemotherapy.

26 Jul 2007

Detecting transmissibility of avian influenza virus in human households

Recent outbreaks of emerging diseases such as SARS and H5N1 avian influenza have underlined the fact that animal pathogens may acquire the ability to spread efficiently in humans but as yet have not.

26 Jul 2007

Portmanteau inhibitors offer new way to tackle HIV

Researchers at the University of Minnesota's Center for Drug Design have developed a new method to combat HIV/AIDS, potentially replacing the traditional cocktail drug approach.

24 Jul 2007

Koronis Pharmaceuticals issued U.S. patent for KP-1461 therapeutic in development for treatment of HIV

Koronis Pharmaceuticals, Inc. has announced the issuance of U.S. Patent No. 7,244,732 that discloses the composition of KP-1461 -- the Company's lead antiviral therapeutic currently in a Phase 2 trial for the treatment of human immunodeficiency virus (HIV) infection.

23 Jul 2007

Scientists clarify molecular basis of interferon action

Scientists at the University of California, Santa Barbara have made a significant discovery relating to viral infections in humans.

20 Jul 2007

Is the U.S. ready for bird flu? No

A new report from the White House has revealed that the United States remains unprepared for a possible bird flu pandemic.

19 Jul 2007

Tibotec Pharmaceuticals submits NDA for investigational HIV treatment

Tibotec Pharmaceuticals Ltd. has announced the submission of a New Drug Application to the U.S. Food and Drug Administration (FDA) for TMC125 (etravirine), an investigational non- nucleoside reverse transcriptase inhibitor (NNRTI), being studied for use with other antiretroviral (ARV) agents as a treatment for people infected with HIV- 1.

19 Jul 2007

Biota and MedImmune announce clinical trial for respiratory syncytial virus antiviral drug

Biota Holdings Limited and MedImmune Inc. today announced the start of a Phase Ia clinical trial for their respiratory syncytial virus (RSV) antiviral drug, BTA9881, with the goal of providing a treatment for RSV-infected infants and adults.

17 Jul 2007

FDA fast tracks ViroPharma's treatment of hepatitis C

ViroPharma has announced that the U.S. Food and Drug Administration (FDA) has granted fast track designation for HCV-796 for treatment of hepatitis C virus infection.

28 Jun 2007

Tamiflu could halve the pandemic influenza death toll versus no intervention

Treatment with the oral antiviral Tamiflu (oseltamivir) and prophylaxis for people exposed to infected patients could be one of the most cost-effective strategies for reducing illness and death during an influenza pandemic.

23 Jun 2007

New understanding of modern pandemic infection

Human resistance to a retrovirus that infected chimpanzees and other nonhuman primates 4 million years ago ironically may be at least partially responsible for the susceptibility of humans to HIV infection today.

23 Jun 2007

Discomfort and disability caused by shingles can be avoided

The painful, burning twinge and irritate skin that can be an early warning sign of shingles is often overlooked or misdiagnosed at the time when antiviral medications can be effected at shortening the outbreak.

23 Jun 2007

Entecavir can compromise HIV treatment

Treating hepatitis B patients with the drug entecavir can cause those who are also infected with HIV to become resistant to two of the most important drugs in the anti-HIV arsenal, according to a new report in the New England Journal of Medicine.

23 Jun 2007

Drug warning prompts treatment changes for those infected with hepatitis B and HIV

Cross-resistance alarms raised earlier this year by Johns Hopkins researchers about a widely used antiviral therapy for hepatitis B liver infections have prompted swift treatment revisions by the drug's maker and governmental agencies.

23 Jun 2007

Reports of abnormal behaviour sends Tamiflu back to the drawing board

The manufacturers of the bird flu drug Tamiflu are about to repeat basic research and clinical trials on the high profile influenza drug.

20 Jun 2007

Analysis of steroids as a treatment for sudden hearing loss

Although steroids are the most widely used treatment for sudden hearing loss, little scientific evidence supports their use or that of any other therapies for this condition, according to a systematic review and meta-analysis both published in the June issue of Archives of Otolaryngology, Head & Neck Surgery.

19 Jun 2007