Apolipoprotein News and Research

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Low level of neuronal receptor LR11 linked to Alzheimer's disease

Results of a new study indicate a strong link between the loss of the neuronal receptor LR11and onset of mild cognitive impairment (MCI), often a harbinger of Alzheimer's disease.

5 Sep 2007

Smoking ups Alzheimer's risk by 50%

According to a new Dutch study people over the age of 55 who are smokers put themselves at a far greater risk of developing dementia than people who do not smoke.

5 Sep 2007

Smoking and Alzheimer's disease

People who smoke are more likely to develop Alzheimer's disease or dementia than nonsmokers or those who smoked in the past, according to a study published in the September 4, 2007, issue of Neurology, the medical journal of the American Academy of Neurology.

4 Sep 2007

High stress and genetic risk factor lead to increased memory decline

High stress levels may contribute to memory loss among people at risk for developing Alzheimer's disease.

28 Aug 2007

Simple test predicts a person's risk for developing dementia within six years with 87 percent accuracy

The test, developed in the study by the researchers, is a 14-point index combining medical history, cognitive testing, and physical examination. It requires no special equipment and can be given in a clinical setting such as a doctor's office or at a patient's bedside.

16 Jun 2007

Diet influenced by genetics

The relative amount of protein, carbohydrate, and fat that people choose to eat may be influenced by genetics, according to new research.

8 Jun 2007

New patented method for transporting medicine across the blood-brain barrier

Researchers at the Blanchette Rockefeller Neurosciences Institute have patented a new way of safely transporting medicine across the blood-brain barrier.

24 May 2007

Pistachios may decrease a person's cardiovascular disease risk

A handful of pistachios may lower cholesterol and provide the antioxidants usually found in leafy green vegetables and brightly colored fruit, according to a team of researchers.

1 May 2007

Gene finding could lead to new pathways for development of Alzheimer's therapeutics

Scientists have known for more than a decade that individuals with a certain gene are at higher risk for developing Alzheimer's disease.

11 Apr 2007

Calories from fat, carbohydrate, and protein may interact with genes

We observed an interaction between APOA5 and dietary fat intake, but we did not see an interaction between APOA5 and carbohydrate or protein intake for any genetic variants of APOA5,” says Ordovas, who is corresponding author of the study.

10 Apr 2007

Reconstituted HDL may have some benefit in coronary atherosclerosis

Preliminary research suggests that use of reconstituted HDL may have some benefit in coronary atherosclerosis, according to a JAMA study published online March 26.

2 Apr 2007

Apolipoprotein C1 protein linked to elevated BMI in people of American Indian and Mexican ancestry

University of Minnesota researchers have discovered a variant of a common blood protein, apolipoprotein C1, in people of American Indian and Mexican ancestry that is linked to elevated body mass index (BMI), obesity and Type 2 diabetes.

22 Feb 2007

Apolipoprotein E gene raises newborns' cerebral palsy risk

Apolipoprotein E (APOE), a gene associated with heightened risk for Alzheimer's disease in adults, can also increase the likelihood that brain-injured newborns will develop cerebral palsy, researchers at Children's Memorial Research Center have discovered.

5 Feb 2007

Juice lowers Alzheimer's risk

In a large epidemiological study, researchers found that people who drank three or more servings of fruit and vegetable juices per week had a 76 percent lower risk of developing Alzheimer's disease than those who drank juice less than once per week.

4 Sep 2006

Donepezil slows brain shrinkage in some patients with mild cognitive impairment

According to a new study, the drug donepezil measurably slows the rate of brain shrinkage in some patients with mild cognitive impairment, a pre-Alzheimer's disease condition. The shrinkage was measured by magnetic resonance imaging (MRI).

18 Jul 2006

Neurons can produce Alzheimer's-linked apolipoprotein E

A question long debated among Alzheimer's disease researchers has been definitively answered by scientists at the Gladstone Institute of Neurological Disease in San Francisco.

10 May 2006

Advancing nanoparticle-based imaging and therapy of brain cancer

Brain cancer is one of the most difficult malignancies to detect and treat, in large part because of the difficulty in getting imaging and therapeutic agents past the so-called blood-brain barrier and into the brain.

9 May 2006

Prefrontal cortex in the brain damaged by both alcoholism and chronic smoking

Alcoholism is commonly associated with chronic smoking, and both alcohol and nicotine are believed to act on the same brain region. Research builds upon previous research that identified four potential alcohol-sensitive genes in the prefrontal cortex, finding that smoking also influences the expression of these genes.

26 Apr 2006

Doctors must listen when patients talk of a failing memory

A team at the Aging and Memory Research Center, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, has found that a higher self awareness of memory difficulties may be associated with brain function decline over time, particularly in older adults with a genetic risk for Alzheimer's disease.

6 Apr 2006

Higher self awareness of memory difficulties may be associated with brain function decline over time

Published in the April issue of the Archives of General Psychiatry, the study offers a greater understanding of how different types and varying degrees of memory complaints may relate to brain function decline, a finding that may lead to early treatment interventions for people who could develop Alzheimer's disease.

4 Apr 2006