Apolipoprotein News and Research

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Evidence A.2 lineage of monkeypox is mutating

In a recent study posted to the bioRxiv* preprint server, a team of researchers from India analyzed the whole genome sequences of the monkeypox virus isolated from monkeypox patients with and without international travel histories to understand the phylogenetic relations and genomic evolution of the virus that could contribute to higher transmission rates.

21 Sep 2022

SARS-CoV-2 generates amyloid in cerebral spinal fluid

In a recent study posted to the bioRxiv* preprint server, an international team of researchers demonstrated amyloid aggregation due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human cerebrospinal fluid (CSF).

20 Sep 2022

Study uncovers molecular changes in the brain’s blood vessels caused by Alzheimer’s susceptibility gene

Recent breakthroughs have revealed a great deal about Alzheimer's disease, but researchers have yet to paint a complete picture of how genetic risk for the illness causes the brain damage that ultimately leads to memory loss and cognitive decline.

30 Aug 2022

Changes in brain connections occur very early in Alzheimer's disease

Although a lot is known about brain alterations in symptomatic Alzheimer's disease (AD), less is known about changes in the brain network early in the disease process.

24 Aug 2022

Study finds link between high-density lipoprotein and COVID-19

A new study has highlighted the significance of high-density lipoprotein COVID-19 pathogenesis and outcome.

24 Aug 2022

Researchers assess lutein nanodisks against ultraviolet light-induced retinal damage

Researchers assessed the role of lutein nanodisks against ultraviolet (UV) light-induced damage to retinal cells.

18 Aug 2022

Genetic variant associated with Alzheimer's disease plays a role in protecting against glaucoma

New research led by scientists at Mass Eye and Ear and Brigham and Women's Hospital, member hospitals of Mass General Brigham, reveals the role that a genetic variant associated with Alzheimer's disease, APOE4, plays in protecting against glaucoma.

16 Aug 2022

Scientists offer a set of recommendations to improve future research on diet and dementia

Anyone searching the internet for brain-healthy foods will find no shortage of stories making dietary recommendations. Some of those stories point to observational studies that have suggested a link between the lower or greater intake of certain foods and the risk of dementia.

5 Jul 2022

Researchers map cancer driver mutations across the human genome

In a recent study published in Nature Biotechnology, researchers explored the causes of cancer by mapping somatic mutation rates across the human genome.

22 Jun 2022

Increased docosahexaenoic acid intake may lower risk for Alzheimer’s and dementia

An increase in the concentration of DHA in RBCs is associated with a reduced risk of Alzheimer's disease and all-cause dementia

21 Jun 2022

The potential mechanisms of SARS-CoV-2 to induce DNA damage

Researchers described potential mechanisms of coronaviruses that could lead to DNA damage and the potential link between SARS-CoV-2 activity and such mechanisms.

14 Jun 2022

Lineages of monkeypox virus in the United States

In a recent work posted to the bioRxiv* preprint server, researchers analyzed various monkeypox virus (MPXV) lineages identified recently in the United States (US).

14 Jun 2022

USA–Japan Workshop participants present cutting-edge research on biomarkers for early detection of cancer

Successful treatment of cancer frequently depends on early detection. However, many cancers are detected late, often after metastasizing to other sites.

9 Jun 2022

USC scientists receive more than $16 million to study the role of blood vessel dysfunction in Alzheimer’s disease

The National Institute on Aging, a division of the National Institutes of Health, awarded Berislav Zlokovic, MD, PhD, director of the Zilkha Neurogenetic Institute, and Arthur W. Toga, PhD, director of the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI), $16.1 million to continue research on the role that blood vessel dysfunction plays in the development of dementia and Alzheimer's disease.

7 Jun 2022

Eating up to one egg per day may help lower cardiovascular disease risk, research suggests

Researchers have shown how moderate egg consumption can increase the amount of heart-healthy metabolites in the blood, publishing their results today in eLife.

24 May 2022

APOB-specific T cells may contribute to inflammation and further the progression of atherosclerosis

Preventing atherosclerosis, the underlying cause of heart disease, means scientists need to understand how immune cells drive inflammation in the arteries.

20 May 2022

Study explores lipid nanoparticles against SARS-CoV-2

Researchers assessed the efficiency of lipid nanoparticles against SARS-CoV-2.

18 May 2022

Hormonal shift during menopause changes women’s blood metabolite profile

In midlife, the risk of cardiometabolic diseases increases in women more rapidly than in men. A study performed at the Faculty of Sport and Health Sciences of the University of Jyväskylä shows that changes in blood metabolite profile accompany the shift in sex hormone levels during menopause.

13 May 2022

Study explores sex-driven differences in individualized clinical management of Alzheimer’s disease risk

A new study demonstrated how individualized clinical management of Alzheimer's disease risk was viable in a clinical outpatient setting.

29 Apr 2022

Dapagliflozin did not reduce risks in patients hospitalized with COVID-19

In a recent randomized clinical trial of hospitalized patients with COVID-19 and cardio-metabolic risk factors, the sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin did not significantly reduce patients' risk of organ failure, kidney problems, or death compared with placebo, although numerically fewer participants treated with dapagliflozin experienced these outcomes. The findings are published in CJASN.