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Investigating the efficacy and safety of existing drugs in patients with rare immune diseases

This month the first study within the DRIMID consortium (DRIMID stands for Drug Rediscovery for Rare Immune Mediated Inflammatory Diseases) has started.

23 Apr 2024

Blood test may predict MS development, UCSF research reveals

In a discovery that could hasten treatment for patients with multiple sclerosis (MS), UC San Francisco scientists have discovered a harbinger in the blood of some people who later went on to develop the disease.

22 Apr 2024

Exploring the versatile roles of tissue macrophages beyond immune defense

The role of resident tissue macrophages (RTMs) in homeostasis and disease.

17 Apr 2024

New murine model sheds light on anti-MDA5 antibody-positive dermatomyositis

Some diseases involve autoimmune reactions, when the body begins to attack its own cells and proteins.

13 Apr 2024

Researchers find new clues to understanding the progression of primary membranous nephropathy

No therapies currently exist that can halt the progression of chronic kidney disease in children or restore the ability of kidney cells to filter blood.

9 Apr 2024

Understanding long COVID: A call for better diagnosis and treatment

A recent review in Nature Reviews Microbiology summarizes the complex mechanisms, significant impacts, and the urgent need for enhanced diagnostics and treatments for long COVID, affecting over 65 million people globally with diverse, debilitating symptoms and systemic health issues.

7 Mar 2024

New study pinpoints key markers for Long COVID diagnosis

Study identifies elevated serologic responses and memory CD8+ T cell clonal expansion as key markers of Long COVID, offering insights into its pathology and potential diagnostic approaches.

18 Feb 2024

Study suggests patients with severe long COVID present with variable symptoms, do not cluster in relation to organs affected or immunological states

A new preprint reports significantly associated findings that may help predict severe long COVID and understand what causes it.

16 Feb 2024

Never-before-documented genetic disorder causes rare lung disease

The macrophage is one of the body's most important inhabitants. Meaning "big eater" in Greek, this immune cell consumes and digests problematic elements from microbes and cancer cells to dust and debris.

8 Feb 2024

Xist lncRNA identified as key trigger in female-biased autoimmune diseases

Researchers uncover that the Xist ribonucleoprotein complex, unique to females, is a key driver of sex-biased autoimmunity, offering new insights into autoimmune disorders' higher prevalence in women.

4 Feb 2024

X-chromosome inactivation and its role in autoimmune susceptibility in females

Somewhere between 24 and 50 million Americans have an autoimmune disease, a condition in which the immune system attacks our own tissues. As many as 4 out of 5 of those people are women.

1 Feb 2024

Study finds patients with long COVID exhibit complement dysregulation with signs of thromboinflammation

Researchers explore inflammatory signatures restricted to patients with active post-acute COVID-19 sequelae.

23 Jan 2024

Defective gene triggers uncontrolled immune attack in young lupus patients

A group of researchers lead by Min Ae Lee-Kirsch from the Department of Pediatrics, Medical Faculty, TUD Dresden University of Technology (Germany), studied four patients from two families who developed symptoms of SLE in the first years of life.

12 Jan 2024

Revolutionary four-biomarker panel offers hope for early ovarian cancer detection

The biomarker CA125 for early detection of ovarian cancer.

11 Jan 2024

Phase 2 trial data shows safety, tolerability and efficacy of imlifidase in GBS patients

Hansa Biopharma today announced positive high-level data from the 15-HMedIdeS-09 phase 2 trial that demonstrated imlifidase was safe and well tolerated when administered prior to standard of care, including rapid improvement in disease-related efficacy measures.

11 Dec 2023

New mechanism revealed for how group A Streptococcus infection reduces type 1 diabetes risk

Researchers have discovered the novel mechanism that underlies a previously reported observation that infection by group A Streptococcus bacteria reduces the risk of later developing Type 1 diabetes.

5 Dec 2023

World-first type 1 diabetes risk screening study in adults opens for recruitment

A world-first research programme led by the University of Bristol that will identify adults at high risk of developing type 1 diabetes opens for recruitment.

15 Nov 2023

High levels of anti-Ro/SSA antibodies linked to fetal heart block in pregnant women

Some individuals with anti-Ro/SSA antibodies (anti–Sjögren's-syndrome–related antigen A autoantibodies, also called anti-Ro antibodies) have autoimmune diseases such as lupus or Sjögren's syndrome, but many have no symptoms.

10 Nov 2023

Research redefines rheumatoid arthritis: Over 314,000 cells analyzed for precise treatment strategies

A new paper recently published in Nature, reported the examination of synovial tissue from the joints of nearly 80 people with RA, in combination with RNA sequencing and surface protein analyses.