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New eye scan may detect onset of Alzheimer's disease

Early structural changes in the back of the eye — now visible with a newly developed eye scan — may indicate the onset of Alzheimer's disease. The research is being presented at the 2016 Annual Meeting of the Association for Research in Vision and Ophthalmology this week in Seattle, Wash.

6 May 2016

Structure of fibril protein could lead to specific targets for diagnosis, treatment of Parkinson's disease

Chemists have identified the complex chemical structure of the protein that stacks together to form fibrils in the brains of Parkinson's disease patients. Armed with this knowledge, researchers can identify specific targets for diagnosis and treatment.

29 Mar 2016

New blood test may potentially facilitate detection of Alzheimer's disease at early stage

Today, Alzheimer's disease is diagnosed too late. In collaboration with a research team at the university and German Center for Neurogenerative Diseases in Göttingen, Researchers at Ruhr-Universität Bochum have developed a blood test that may potentially facilitate detection of Alzheimer's at an early stage. It is based on an immuno-chemical analysis using an infrared sensor.

15 Mar 2016

Real maple syrup shows promise in protecting brain health

As part of a two-day symposium at the annual meeting of the American Chemical Society, a group of international scientists shared promising results of 24 studies exploring the beneficial effects of natural products on the prevention of neurodegenerative diseases, particularly Alzheimer's disease.

14 Mar 2016

Could environmental toxins trigger amyloid plaques in the brain? An interview with Dr Paul Alan Cox

Many Chamorro villagers on the island of Guam perished from a puzzling paralytic disease that combines aspects of ALS, Alzheimer's, and Parkinson's disease.

From Huron Digital Pathology 14 Mar 2016

Scientists sort out mechanism of Alzheimer's disease development

A group of the Lomonosov Moscow State University scientists, together with their colleagues from the Institute of Molecular Biology, Russian Academy of Sciences and the King's College London, succeeded in sorting out the mechanism of Alzheimer's disease development and possibly distinguished its key trigger.

11 Mar 2016

Small, sensitive biosensors could help personalize treatment for Alzheimer's disease

A portable biosensor that could show how disease is progressing in patients with Alzheimer's could greatly improve people's quality of life in the future, according to a new review published in Biosensors and Bioelectronics.

10 Mar 2016

Research provides important new insights into beginning stages of primary progressive aphasia

The recent ability to peer into the brain of living individuals with a rare type of language dementia, primary progressive aphasia (PPA), provides important new insights into the beginning stages of this disease -- which results in language loss -- when it is caused by a buildup of a toxic protein found in Alzheimer's disease.

8 Mar 2016

Research highlights association of western diet with Alzheimer's disease

Recent research has established associations between certain environmental factors, including eating a western diet and being sedentary, with an increased susceptibility to Alzheimer's disease. In fact, it is estimated that a combination of diet and inactivity contributes to as many as 25% of Alzheimer's cases. Nonetheless, little is known about the exact disease mechanisms and how or why this increasingly common middle-age lifestyle can play such a big role in subsequent cognitive function.

7 Mar 2016

Study identifies biomarker that plays role in early stages of Alzheimer's disease

A multicenter study led by Christian Haass and Michael Ewers of Ludwig-Maximilians-Universitaet in Munich has identified a biomarker associated with the activation of an innate immune response to neural damage during early stages of Alzheimer's disease.

4 Mar 2016

Frontotemporal dementia often misdiagnosed as Alzheimer’s disease in many patients

Many patients showing signs of dementia are quickly diagnosed with Alzheimer's disease when they might actually suffer from frontotemporal dementia, delaying the appropriate treatment for them.

25 Feb 2016

Immune cells may play greater role in Alzheimer's disease than originally thought

Immune cells that normally help us fight off bacterial and viral infections may play a far greater role in Alzheimer's disease than originally thought, according to University of California, Irvine neurobiologists with the Sue & Bill Gross Stem Cell Research Center and the Institute for Memory Impairments and Neurological Disorders.

24 Feb 2016

Seafood consumption may benefit older adults at risk for Alzheimer's disease

New research published Feb. 2 in the Journal of the American Medical Association found that older adults with a major risk gene for Alzheimer's disease known as APOE?4 who ate at least one seafood serving per week showed fewer signs of Alzheimer's-related brain changes. In contrast, this association was not found in the brains of volunteers who ate fish weekly but did not carry the risk gene.

3 Feb 2016

Synaptic plasticity alterations responsible for memory impairment in Alzheimer's disease

Neurons communicate with one another by synaptic connections, where information is exchanged from one neuron to its neighbor. These connections are not static, but are continuously modulated in response to the ongoing activity (or experience) of the neuron. This process, known as synaptic plasticity, is a fundamental mechanism for learning and memory in humans as in all animals.

27 Jan 2016

Preventing memory loss in Alzheimer's Disease, a new key mechanism

26 Jan 2016

NeuroQuest to start U.S. clinical validation trials of blood test for early diagnosis of Alzheimer's disease

NeuroQuest Development Center, Inc., today announced they have entered into a service agreement with the University of California, San Diego for collection and processing of blood samples for their U.S. clinical validation trials.

10 Dec 2015

Low levels of BRCA1 protein in the brain linked to dementia

Mutant forms of breast cancer factor 1 (BRCA1) are associated with breast and ovarian cancers but according to new findings, in the brain the normal BRCA1 gene product may also be linked to Alzheimer's disease. The results, published in Nature Communications, suggest that low levels of BRCA1 protein in the brain may contribute to dementia.

1 Dec 2015

Discovery opens up new avenue for research on potential treatments for Alzheimer's disease

A team of researchers led by UNSW Australia scientists has discovered how connections between brain cells are destroyed in the early stages of Alzheimer's disease - work that opens up a new avenue for research on possible treatments for the degenerative brain condition.

27 Nov 2015

Protein aggregates as harmful as neurodegenerative-disease-related proteins, shows study

Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.

20 Nov 2015

Anavex reports safety and efficacy data of ANAVEX 2-73 Phase 2a trial in Alzheimer’s patients

On Saturday, investigators presented positive safety and cognitive efficacy data for ANAVEX 2-73, the Company’s lead investigational oral treatment for Alzheimer’s disease targeting sigma-1 and muscarinic receptors, which are believed to reduce protein misfolding including reduction of beta amyloid, tau protein and inflammation at the international CTAD 2015 conference in Barcelona, Spain.

11 Nov 2015