Bupivacaine News and Research

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Revolutionizing pain management: Study highlights effectiveness of low-dose local anesthetics

The therapeutic efficacy of low-dose local anesthetics (LAs) in various clinical conditions, highlighting gaps in current research for future exploration.

23 Nov 2023

New approach to pain management can reduce opioid use after urethroplasty

For men undergoing surgery to repair scarring in the urethra (urethroplasty), a new approach to pain management can reduce the need for strong opioid drugs without compromising pain control, reports a study in Urology Practice, an Official Journal of the American Urological Association.

21 Feb 2023

Study: More than two-thirds of the patients recover from knee replacement without opioids

A retrospective case series study led by Dr. Vinod Dasa, Professor of Clinical Orthopaedics at LSU Health New Orleans School of Medicine, reports that more than two-thirds of the patients who underwent total knee replacement did not need opioids for postoperative pain.

25 Mar 2022

$Local anesthetic use for hip fracture patients on the day of admission is increasing, data suggests$

Local anesthetic use for hip fracture patients on the day of admission is increasing, data suggests

Patients with traumatic injuries who are treated in the emergency room are susceptible to opioid-related adverse drug effects. Increased use of regional anesthesia can be helpful in the effort to reduce the use of opioids. However, it's not clear how often patients receive regional anesthesia prior to going to the operating room.

23 Mar 2022

Change in care protocol of weight-reduction operations exceeds its desired effect

A change in the care protocol of patients undergoing weight-reduction operations exceeded its desired effect by cutting postoperative hospital stays in half, reducing postoperative hospital readmissions by 38 percent, and reducing the amount of opioids the patients were sent home with by 95 percent, according to study results from a large bariatric and metabolic surgery center in Charleston, S.C.

23 Jul 2019

FDA warns against use of unapproved pain medications with implanted pumps

The U.S. Food and Drug Administration today alerted health care providers and patients about the serious complications that can occur when using medications not approved for use with implanted pumps that deliver medication into the spinal fluid to treat or manage pain.

15 Nov 2018

Local anesthetic drug not linked to reduction in opioid use, complications after knee surgery

Contrary to what some studies may suggest, the local anesthetic drug, liposomal bupivacaine, did not reduce in-hospital opioid prescriptions or opioid-related complications in patients who received the drug during total knee replacement surgery as part of a multimodal approach to manage postsurgical pain, finds a new study published in the Online First edition of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists.

22 May 2018

Mepivacaine is found to be an effective spinal anesthetic for knee replacement surgery

A numbing medicine largely abandoned decades ago for pain control during surgery could be making a comeback as an effective spinal anesthetic for today's modern-day knee replacement.

9 May 2018

ASA survey: Drug shortages impact care for patients undergoing anesthesia

A national drug shortage crisis is potentially affecting the care received every day for thousands of patients undergoing anesthesia.

25 Apr 2018

Safety violations compound pain of painkiller shortages

Safety violations at a major compounding pharmacy are exacerbating hospital shortages of key painkillers, particularly in California where health officials have taken the "extraordinary" step of prohibiting sales from one of its plants.

16 Apr 2018

Epidural pain relief with fentanyl during childbirth does not affect early breastfeeding success

Including the opioid fentanyl in the solution used to maintain an epidural during childbirth does not appear to affect the success of breastfeeding six weeks after delivery, according to a study published in Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists. Previous research has suggested fentanyl might be associated with early termination of breastfeeding.

8 Nov 2017

DURECT reports successful completion of DUR-928 Phase 1 study for acute use indications

DURECT Corporation today announced the successful completion of a Phase 1 clinical trial with an injectable formulation of DUR-928 intended for acute use indications. DUR-928 is an endogenous, small-molecule, new chemical entity (NCE), which may have broad applicability in metabolic diseases such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), and in acute organ injuries such as acute kidney injury (AKI).

6 Jan 2016

New study compares outcomes from two postoperative pain control methods in knee replacement patients

A new study published today in The Journal of the American Osteopathic Association compared outcomes from two types of postoperative pain control methods in a group of patients who had both of their knees replaced.

1 Dec 2015

Data demonstrates benefits associated with use of EXPAREL in hip, knee replacement patients

Pacira Pharmaceuticals, Inc. today announced data demonstrating the benefits associated with the use of EXPAREL (bupivacaine liposome injectable suspension) in a study of over 2,200 hip and knee replacement patients.

27 Mar 2015

Injection technique provides pain relief following knee replacement surgery

It's estimated that more than half of adults in the United States diagnosed with knee osteoarthritis will undergo knee replacement surgery.

22 Dec 2014

FDA approves additional manufacturing suite for Pacira’s EXPAREL

Pacira Pharmaceuticals, Inc. today announced that the U.S. Food and Drug Administration approved an additional bulk manufacturing suite, referred to as Suite C, for EXPAREL (bupivacaine liposome injectable suspension). The suite is housed at the company's Science Center Campus in San Diego, where EXPAREL is currently manufactured.

31 Mar 2014

New approach to breast reconstruction surgery decreases use of postoperative opioid painkiller

A new approach to breast reconstruction surgery aimed at helping patients' bodies get back to normal more quickly cut their postoperative opioid painkiller use in half and meant a day less in the hospital on average, a Mayo Clinic study found.

4 Mar 2014

Pacira Pharmaceuticals initiates Phase 3 clinical trial of EXPAREL in femoral nerve block

Pacira Pharmaceuticals, Inc. (NASDAQ:PCRX) today announced that the Phase 3 clinical trial assessing the safety and efficacy of EXPAREL® (bupivacaine liposome injectable suspension) in femoral nerve block for total knee arthroplasty met its primary efficacy endpoint.

27 Feb 2014

Study: Liposomal bupivacaine can provide longer-lasting nerve blocks

Can a new liposomal bupivacaine product provide long-lasting nerve block with a single injection? An initial study in humans shows promise-but also some "confusing results," reports the November issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society.

29 Oct 2013

FDA accepts DURECT's New Drug Application for POSIDUR

DURECT Corporation today announced that the New Drug Application for the investigational product POSIDUR (SABER-Bupivacaine) has been accepted by the U.S. Food and Drug Administration indicating that the application is sufficiently complete to permit a substantive review.

20 Jun 2013