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Exposure to HIV virus, antiretroviral therapy before birth linked to obesity and asthma-like symptoms

Teens and young adults who were exposed to HIV and antiretroviral therapy before birth but are HIV-negative themselves are at increased risk of obesity and asthma-like symptoms, according to research to be presented Saturday, March 23 at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La.

25 Mar 2019

Study offers new evidence that narcolepsy is an autoimmune condition

In a study of narcolepsy patients, researchers at the University of Copenhagen have made an important discovery that could help pave the way for improved treatment of the chronic condition.

18 Mar 2019

Scientists find new proof that narcolepsy is an autoimmune disease

Researchers from the University of Copenhagen have discovered autoreactive cells in persons suffering from narcolepsy.

15 Mar 2019

HIV patients diagnosed with tuberculosis more likely to die within 10 years, study finds

Among people with HIV in Latin America, those diagnosed with tuberculosis at an initial clinic visit were about twice as likely to die within 10 years as people not initially diagnosed with TB, according to findings from a large observational study.

7 Mar 2019

Study reveals how helper T cells support memory cells to function optimally

The immune system's killer T cells are crucial in fighting viral infections. A fraction of them, called 'memory cells', live on once infection is controlled in order to fight re-infection by the same virus. They are of great interest as the basis of T cell-based vaccination and immunotherapies.

20 Feb 2019

Anti-cancer immunotherapy could be used to fight HIV

Researchers at the University of Montreal Hospital Research Centre have shown that immunotherapy treatments against cancer could reduce the amount of virus that persists in people on triple therapy.

19 Feb 2019

Immune checkpoint molecule protects against future development of cancer

A research team at the University of Louisville has discovered that an immune checkpoint molecule they developed for cancer immunotherapy, also protects against future development of multiple types of cancer when administered by itself.

15 Feb 2019

Study: CD4+ T cells could be important mediators of protection against Zika virus

Immune cells called CD4+ T cells could be important mediators of protection against the Zika virus, according to a study published January 24 in the open-access journal PLOS Pathogens by Sujan Shresta of the La Jolla Institute for Allergy and Immunology, and colleagues.

25 Jan 2019

New resource-based approach to improve HIV care in low- and middle-income countries

A practical resource-based public health approach for the rapid initiation of antiretroviral therapy in HIV-infected individuals living in low- and middle-income countries could save thousands of lives, according to an Essay published January 15 in the open-access journal PLOS Medicine by Mark Tenforde of the University of Washington School of Medicine, and colleagues.

18 Jan 2019

Study: Reactivation of HIV-infected cells depends on its size and cell cycle

Thanks to the development of antiretroviral drugs, human immunodeficiency virus is considered a manageable chronic disease today.

27 Dec 2018

New approach to destroy HIV reservoirs

Current HIV treatments need to be taken for life by those infected as antiretroviral therapy is unable to eliminate viral reservoirs lurking in immune cells. Institut Pasteur scientists have identified the characteristics of CD4 T lymphocytes that are preferentially infected by the virus - it is their metabolic (or energy-producing) activity1 that enables the virus to multiply.

21 Dec 2018

Liver immune cells contain inert HIV and are unlikely to reproduce infection, study reveals

In a proof-of-principle study, researchers at Johns Hopkins revealed that certain immune system cells found in the human liver, called liver macrophages, contain only inert HIV and aren't likely to reproduce infection on their own in HIV-infected people on long-term antiretroviral therapy.

30 Nov 2018

ECDC and WHO release latest data on HIV epidemic in the European Region

The European Centre for Disease Prevention and Control and the WHO Regional Office for Europe release the latest data on the HIV epidemic in the European Region, marking the 30th anniversary of World AIDS Day.

29 Nov 2018

Reducing cellular proliferation could help deplete HIV reservoir and lead to a functional cure

A majority of the HIV-infected cells that persist in HIV-infected individuals even during suppressive antiretroviral therapy originated from cellular proliferation, not viral replication, according to new research published in Nature Communications.

17 Nov 2018

Mechanisms that govern HIV latency differ in the gut and blood, finds study

Mechanisms that govern HIV transcription and latency differ in the gut and blood, according to a study published November 15 in the open-access journal PLOS Pathogens by Steven Yukl of San Francisco Veterans Affairs Medical Center and the University of California, San Francisco, and colleagues.

16 Nov 2018

Treating children with 'bubble baby disease'

An international study published in the journal Blood by researchers led by Dr. Elie Haddad, a pediatric immunologist and researcher at CHU Sainte-Justine and professor at Université de Montréal, highlights the urgent need to develop better treatment strategies for patients suffering from severe combined immune deficiency.

15 Nov 2018

Small populations of normal T cells could modify disease severity in patients with XLP1

Human SH2D1A mutations resulting in X-linked lymphoproliferative syndrome type 1 are associated with a unique susceptibility to the Epstein-Barr virus, which may lead to fatal infectious mononucleosis.

9 Nov 2018

Researchers identify pathway to resolve allergic asthma

A group of Brazilian researchers succeeded in preventing allergic asthma from progressing in experimental models by increasing the amount of a protein. This increase, in turn, blocked the CD4+ T lymphocytes responsible for producing a cytokine that triggers a cascade of events resulting in the onset and progression of the disease.

6 Nov 2018

New approach may lead to protective vaccines for immunocompromised patients

A study led by Som Nanjappa at the University of Illinois College of Veterinary Medicine identifies a cellular target that may improve efficacy in vaccines designed to protect immunocompromised individuals from potentially deadly opportunistic infections.

26 Oct 2018

Gut microbiota could play greater role in pathogenesis of MS than previously thought

In multiple sclerosis, a defective response of the body’s own immune system leads to brain tissue damage. Gastrointestinal microbiota could play a far greater role in the pathogenesis of the disease than previously assumed, researchers at the University of Zurich have now found.

11 Oct 2018