Caenorhabditis elegans is a free-living, transparent nematode (roundworm), about 1 mm in length, which lives in temperate soil environments.
Muscle decline caused by aging and certain diseases could be dramatically slowed by stopping a chain reaction that damages cells, new research shows.
Princeton University researchers have discovered that learned behaviors can be inherited for multiple generations in C. elegans, transmitted from parent to progeny via eggs and sperm cells.
A new Cornell University-led study finds that the genome for a widely researched worm, on which countless studies are based, was flawed. Now, a fresh genome sequence will set the record straight and improve the accuracy of future research.
Dopamine is responsible for sex-specific variations in common behaviors, finds a study of worm movements published in JNeurosci.
As an organism grows and responds to its environment, genes in its cells are constantly turning on and off, with different patterns of gene expression in different cells. But can changes in gene expression be passed on from parents to their children and subsequent generations?
A group of Brazilian scientists have long conducted experiments with roundworms to investigate the role of schizophrenia-linked genes in patients' response to antipsychotic drugs. The results obtained thus far point to new ways of understanding resistance to certain classes of medication.
Using roundworms, one of Earth's simplest animals, Rice University bioscientists have found the first direct link between a diet with too little vitamin B12 and an increased risk of infection by two potentially deadly pathogens.
It's the small pieces that make the big picture, and in this case, the pieces can't be seen by the naked eye. New research at the Okinawa Institute of Science and Technology Graduate Universit used microscopy techniques to piece together the brain of the millimeter-long Caenorhabditis elegans, revealing that their neurons fire action potentials - a spike in voltage due to neurons sending sensory information in the cell membrane.
Genetic manipulation that more than doubles lifespan also leads to better offspring - according to new collaborative research from the University of East Anglia and Uppsala University.
Having absolute control of the activity of a molecule in an organism. Deciding when, where and how a drug is activated. These are some of the goals expected to be reached with the so-called photoswitchable molecules, compounds that, in the presence of certain light waves, change their properties.
Perpetually hungry, worms are strategic when it comes to searching for food. The microscopic roundworm Caenorhabditis elegans, or C. elegans, is known to spend up to 20 minutes seeking out snacks in its immediate surroundings before endeavoring to look elsewhere.
The smell of food induces a variety of physiological processes in our body. Thus, the production of saliva and digestive enzymes is stimulated before the actual food intake in order to prepare the gastrointestinal tract for the upcoming digestive process.
CRISPR is a technique that is revolutionizing biomedical research through high-precision genome editing. However, even though it allows the creation or correction of mutations consisting of a single or few nucleotides with relative ease, it still possesses limitations upon introducing larger fragments of DNA in the genome.
When humans experience stress, their inner turmoil may not be apparent to an outside observer. But many animals deal with stressful circumstances - overcrowded conditions, not enough food - by completely remodeling their bodies.
An antibiotic, minocycline, can increase the lifespan of roundworms by preventing the build-up of proteins during aging, a study in the open-access journal eLife reports.
A professor at Worcester Polytechnic Institute is exploring aging on the molecular level, examining how the lipids found in our bodies, particularly those in our cell membranes, change as we age, and how those changes may affect bone and muscle strength, brain health, and our propensity for age-related diseases, including Alzheimer's disease.
A team of researchers led by Principal Investigator Dr Jan Gruber from Yale-NUS College has discovered a combination of pharmaceutical drugs that not only increases healthy lifespan in the microscopic worm Caenorhabditis elegans (C. elegans), but also delays the rate of ageing in them, a finding that could someday mean longer, healthier lives for humans.
A new study suggests that if the epigenetics of sperm chromosomes are altered by the environment a father experiences, then this could affect offspring’s health.
The small SynuClean-D molecule interrupts the formation of the alpha-synuclein amyloid fibers responsible for the onset of Parkinson's disease, and reverts the neurodegeneration caused by the disease.
Scientists stunted the puberty of male worms by starving them before they underwent sexual maturation. In a study funded by the National Institutes of Health, the scientists suggested that stress from starvation even days before sexual maturation prevented normal changes in the wiring patterns of key neuronal circuits, which caused adult male worms to act immature.