Cell Metabolism News and Research

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Removing a gene prevents Type 1 diabetes in mice by disguising beta cells

Removing a gene from the cells that produce insulin prevents mice from developing Type 1 diabetes by sparing the cells an attack from their own immune system, a new UW-Madison study shows.

26 Mar 2020

Deleting a gene prevents Type 1 diabetes in mice by disguising insulin-producing cells

Scientists have innovated a potential method of preventing Type 1 diabetes in those at high risk.

26 Mar 2020

The cost of excessive sugar in the diet

A new study from the MRC London Institute of Medical Sciences, in the UK, reports that while eating foods rich in sugar does not necessarily make you fat, they can make you very sick. They do this by increasing the level of a compound called uric acid in the blood. The study is published in the journal Cell Metabolism in March 2020.

19 Mar 2020

Dietary sugar has negative impact on health independent of obesity

Sugar-rich diets have a negative impact on health independent of obesity reports a new study led by the MRC London Institute of Medical Sciences, UK.

19 Mar 2020

Single-drug therapy can attack several cellular targets using different modes of action

Clinicians combat the drug resistances of some cancer types by using a combination of different drugs. To make this approach more effective, chemists have designed a chemical conjugate that can simultaneously attack several cellular targets using different modes of action.

13 Mar 2020

Study uncovers novel relationships between SLCs and cytotoxic drugs in human cells

Solute carriers represent the largest family of transmembrane transporters in the human genome, with over 400 members arranged into 65 families.

9 Mar 2020

Fatty nutrients control certain neurons in the reward circuit

Energy-dense food, obesity and compulsive food intake bordering addiction: the scientific literature has been pointing to connections between these for years.

5 Mar 2020

Boosting energy levels within damaged nerve fibers may promote axonal regeneration

Each year, thousands of people in the United States experience a spinal cord injury, damaging the system of nerves that the brain and body use to communicate.

3 Mar 2020

Yale study may help reconcile conflicting findings about low-calorie sweeteners

Several studies in recent years have reported that low-calorie sweeteners in foods and beverages disrupt the human metabolism, promoting the development of diabetes and obesity.

3 Mar 2020

Supplying nutritional amino acid restores spatial memory in mouse model of Alzheimer's

Scientists at the Laboratoire des Maladies Neurodégénératives and the Neurocentre Magendie have just shown that a metabolic pathway plays a determining role in Alzheimer's disease's memory problems.

3 Mar 2020

Increasing energy supply within injured spinal cord nerves could help them heal

When the spinal cord is injured, the damaged nerve fibers--called axons--are normally incapable of regrowth, leading to permanent loss of function.

3 Mar 2020

Michael Hall named winner of 2020 Sjöberg Prize

Michael N. Hall, Ph.D., the National Foundation for Cancer Research's (NFCR) 2017 Szent-Györgyi Prize for Progress in Cancer Research winner, and David Sabatini, M.D., Ph.D., were named winners of the 2020 Sjöberg Prize "for their discovery of the target of rapamycin and the mammalian target of rapamycin, and their roles in the control of cell metabolism and growth."

28 Feb 2020

Targeting one's internal clock could prevent or slow breast cancer progression

City of Hope scientists have identified an unlikely way to potentially prevent or slow the progression of aggressive breast cancer: target one's internal clock.

13 Feb 2020

Novel drug combination discovered to induce high rates of human beta cell proliferation

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a novel combination of two classes of drugs that, together, cause the highest rate of proliferation ever observed in adult human beta cells- the cells in the pancreas that produce insulin- without harming most other cells in the body.

12 Feb 2020

New noninvasive way to monitor the health of brain cells using an infrared laser

With no way to reliably tell whether an athlete has a concussion, many may be playing with an undiagnosed injury. Likewise, 2 million people die every year because we don't have an early warning when brain cells are dying--and another 4 million experience cognitive disabilities.

3 Feb 2020

Turning stink into therapy for atherosclerosis

In an amusing but amazing turnaround, it seems the most foul-smelling compound on earth, called putrescine, could help relieve chronic inflammation, most importantly in the arterial thickening called atherosclerosis. This discovery is reported in the journal Cell Metabolism in January 2020.

30 Jan 2020

New uses for old medicines

It turns out that in the rush to invent new drugs to treat cancers, scientists may have overlooked some obvious possibilities of existing drugs currently being used for other diseases. A new study says that therapies for diabetes, inflammation and alcoholism, and even for dog arthritis, can also result in the successful killing of cancer cells in culture.

20 Jan 2020

CALCR neurons may influence long-term control of food intake and body weight

Ever eaten something, gotten sick and then didn't want to eat that food again because of how it made you feel? That's because a signal from the gut to the brain produced that sickness, creating a taste aversion.

17 Jan 2020

Leukemic cells are addicted to vitamin B6, research shows

Scientists have discovered that Acute Myeloid Leukemia (AML) grows by taking advantage of the B6 vitamin to accelerate cell division.

13 Jan 2020

Researchers identify new prevention strategy for type 1 diabetes

A protein newly identified as important in type 1 diabetes can delay onset of the disease in diabetic mice, providing a new target for prevention and treatment in people, according to research led by scientists at the U.S. Department of Energy's Pacific Northwest National Laboratory and Indiana University School of Medicine.

9 Jan 2020