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FDA approves new drug to treat thrombocytopenia in adults with chronic liver disease

The U.S. Food and Drug Administration today approved Doptelet (avatrombopag) tablets to treat low blood platelet count (thrombocytopenia) in adults with chronic liver disease who are scheduled to undergo a medical or dental procedure. This is the first drug approved by the FDA for this use.

22 May 2018

Study: Macrophages play key role in maintaining stem cell niche of mammary gland

A new study finds that one of the toughest characters in the immune system, the macrophage, has a nurturing side, at least when it comes to guarding the developing breast.

18 May 2018

New therapeutic strategy exploits acquired vulnerability in drug-resistant cancer

Cancer cells that develop resistance to drugs, pay a price for this, by simultaneously developing a new vulnerability. If this acquired vulnerability can be identified, it may be exploited clinically.

10 May 2018

New review of infants with congenital hyperinsulinism shows surgery benefits

A review of nearly 500 cases of infants with severe congenital hyperinsulinism who underwent partial or near-total removal of their pancreas for persistent hypoglycemia at Children's Hospital of Philadelphia showed that surgeons can cure virtually all patients with the focal, or localized, form of the rare genetic disease.

7 May 2018

Researchers uncover new details on how the cerebellum predicts and learns from mistakes

In studies with monkeys, Johns Hopkins researchers report that they have uncovered significant new details about how the cerebellum -- the "learning machine" of the mammalian brain -- makes predictions and learns from its mistakes, helping us execute complex motor actions such as accurately shooting a basketball into a net or focusing your eyes on an object across the room.

4 May 2018

Nearly 50 people present with rare eye cancer - ocular melanoma

At least 50 people have been diagnosed with a rare type of eye cancer called ocular melanoma. They are all residents of two locations - Huntersville, North Carolina, and Auburn, Alabama. The cancer is rare and occurs in only six per 1 million population. The high rate of incidence of this cancer in these two locations has stumped researchers.

2 May 2018

Researchers show how Spred1 molecule protects HSC homeostasis under diet-induced stress

Researchers at Kanazawa University report in Cell Stem Cell how the Spred1 molecule is involved in hematopoietic stem cell self-renewal. Experiments with mouse models show that under normal conditions, Spred1 acts as a negative regulator, while under diet-induced stress, it protects hematopoietic homeostasis.

28 Apr 2018

Antioxidant treatment may decrease cardiovascular risk in women with type 1 diabetes

The high estrogen levels that typically afford younger women protection from cardiovascular disease appear to instead multiply their risk if they have type 1 diabetes, researchers say.

17 Apr 2018

Painkiller use during pregnancy could affect unborn child's fertility in later life

Taking painkillers during pregnancy could affect the fertility of the unborn child in later life, research suggests.

16 Apr 2018

Protein linked with Alzheimer's disease affects different brain cells differently

Amyloid beta, a protein linked with Alzheimer's disease, has different properties in different cell types in the brains of fruit flies.

13 Apr 2018

Research reveals immune suppressive role of soluble antibodies in tumor progression

Wistar researchers have found that soluble antibodies promote tumor progression by inducing accumulation of myeloid-derived suppressor cells (MDSCs) in pre-clinical cancer models. Results were published online in Cancer Immunology Research.

13 Apr 2018

Researchers develop improved method for calculating type 1 diabetes risk

An international research group headed by scientists from Helmholtz Zentrum München has developed a method for calculating the risk for developing type 1 diabetes that is significantly superior to earlier methods.

4 Apr 2018

Computational biologists develop algorithm to align datasets with single-cell resolution

A team of computational biologists has developed an algorithm that can 'align' multiple sequencing datasets with single-cell resolution.

3 Apr 2018

Combined treatment prolongs survival in mouse models of malignant mesothelioma

Combined treatment with two cancer immunotherapy drugs - one a novel immune modulator and one that focuses and activates the antitumor immune response - significantly prolonged survival in mouse models of the aggressive cancer malignant mesothelioma.

2 Apr 2018

UTSW study reveals mechanisms underlying development of Sonic Hedgehog medulloblastoma

A delicate balance during brain development could have profound implications for understanding and treating medulloblastoma, the most common malignant brain tumor affecting children.

29 Mar 2018

Blood donor scraps help researchers to discover new insight into human immune system

Iowa State University researchers have discovered new insight into the human immune system from an unlikely source, the leftover material from blood donation banks.

16 Mar 2018

New study identifies the body's 'glucostat'

It is the pancreatic islets that have the overall responsibility for maintaining normal blood glucose levels in our bodies, according to a new study by researchers at Karolinska Institutet in Sweden and the University of Miami Miller School of Medicine, USA.

6 Mar 2018

Experts develop process for marker-free cell selection

At this year's analytica trade fair in Munich, three Fraunhofer Institutes will be presenting a project from pre-competitive research. Biologists, computer scientists and laser experts have developed a process to analyze and select cells and then examine their protein production. In pharmaceutical research, this will make it possible to develop active ingredients much faster than before.

6 Mar 2018

NETRF awards six new research grants to improve treatments for neuroendocrine tumors

The Neuroendocrine Tumor Research Foundation today awarded six new research grants totaling $1.85 million to leading academic institutions around the world.

5 Mar 2018

Unique progenitor cells in the pancreas have potential to develop glucose-responsive beta cells

Scientists from the Diabetes Research Institute at the University of Miami Miller School of Medicine have confirmed the existence of progenitor cells within the human pancreas that can be stimulated to develop into glucose-responsive beta cells.

28 Feb 2018