Central Nervous System News and Research

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Cold Spring Harbor Protocols features organ and cell culture methods

Understanding the function of organs like the brain, kidney, and reproductive tissues requires experimental systems that allow for the study and manipulation of developing cells and tissues in the laboratory.

4 Nov 2008

Titan Pharmaceuticals updates on Probuphine patent application

Titan Pharmaceuticals, Inc. today announced that it has received an Office Action from the U.S. Patent and Trademark Office (PTO) rejecting the claims in the Company's method of use patent application for the use of Probuphine in the treatment of opioid addiction and chronic pain.

31 Oct 2008

Scientists discover a catalytic antibody that degrades a known appetite stimulant

The antibody works against the gastric hormone ghrelin (pronounced "grell-in"), which has been linked to weight gain and fat storage through its metabolic actions. These findings point towards a potentially novel treatment for obesity that would interfere directly with the some of the biological mechanisms determining weight.

28 Oct 2008

Memory Pharmaceuticals issued key U.S. patent for series of nicotinic alpha-7 receptor agonists

Memory Pharmaceuticals Corp. has announced the issuance of U.S. Patent No. 7,429,664, which provides composition of matter patent protection for a series of nicotinic alpha-7 receptor agonists.

27 Oct 2008

Exposure to low doses of mercury changes the way the arteries work

An international team of researchers has shown that mercury is another important factor in cardiovascular disease as it changes the way arteries work. One of the possible sources of exposure of humans to mercury is by eating contaminated fish.

23 Oct 2008

Gene find sheds light on motor neuron diseases like amyotrophic lateral sclerosis

Scientists have identified a gene in mice that plays a central role in the proper development of one of the nerve cells that goes bad in amyotrophic lateral sclerosis, or Lou Gehrig's disease, and some other diseases that affect our motor neurons.

22 Oct 2008

Targeted cell delivery to the cervical spinal cord is a promising strategy to slow loss of motor neurons in ALS

In a disease like ALS - one that's always fatal and that has a long history of research-resistant biology - finding a proof of principle in animal models is significant.

20 Oct 2008

People with diabetes lose more than money

It is not about money. No amount of money will give back my limb" said a 65 years old woman with diabetes (name withheld on request) who underwent limb amputation at the Gandhi Memorial & Associated Hospitals (GM & AH).

7 Oct 2008

Multiple sclerosis patients have higher spinal fluid levels of suspicious immune molecule

A protein that helps keep immune cells quiet is more abundant in the spinal fluid of patients with multiple sclerosis (MS), further boosting suspicion that the protein, TREM-2, may be an important contributor to the disease.

29 Sep 2008

Pain is not a symptom of arthritis, pain causes arthritis

Pain is more than a symptom of osteoarthritis, it is an inherent and damaging part of the disease itself, according to a study published today in journal Arthritis and Rheumatism.

29 Sep 2008

Out of Iraq emerges hope for those with the severest of head injuries

There may be more hope than has been recognized for some people with severe brain injuries, according to a U.S. neurosurgeon who earlier this year spent four months in Iraq treating soldiers and civilians. Jason Huang, M.D., this week presented his results from his experience in Iraq at the annual meeting of the Congress of Neurological Surgeons in Orlando, Fla.

24 Sep 2008

Research shows mobile phones raise children's risk of brain cancer by five times

New research from Sweden is certain to alarm many as it has found that young people today are five times more likely to get brain cancer if they are mobile phones users.

22 Sep 2008

Keppra XR approved in the U.S. for partial onset seizures

UCB announced today that the U.S. Food and Drug Administration (FDA) has approved Keppra XR (levetiracetam extended-release tablets) for use as an add-on to other antiepileptic treatments for people with partial onset seizures who are 16 years of age and older. Keppra XR is expected to be available in U.S. pharmacies at the end of September 2008.

15 Sep 2008

Naltrexone-derived pyridomorphinan shows promise for treatment of alcoholism

Southern Research Institute and Gallo Research Center today announced that peer-reviewed results from a study testing Naltrexone-derived pyridomorphinan (SoRI-9409) will be published in the December 2008 issue of the journal Biological Psychiatry.

11 Sep 2008

Trial demonstrates safety and efficacy of neurally acting anti-migraine agent for treatment of acute migraine

CoLucid Pharmaceuticals, Inc., an innovative biotechnology company focusing on therapies for central nervous system disorders, announced Phase II results of its lead compound COL-144 in the treatment of acute migraine. Results demonstrated that COL-144 was safe and effective in relieving migraine headaches.

7 Sep 2008

FDA 'fast track' granted to BioMS Medical for lead drug, dirucotide for the treatment of multiple sclerosis

BioMS Medical Corp has announced that the Food and Drug Administration (FDA) of the United States has granted fast track designation for the Company's lead drug, dirucotide (MBP8298), for the treatment of secondary progressive MS (SPMS). Dirucotide (MBP8298) is currently being evaluated in a U.S. pivotal phase III trial, named MAESTRO-03, at 68 sites with approximately 510 patients.

4 Sep 2008

Brain growth and development in very premature or low-weight infants

Brain development in infants who are born very prematurely is still incomplete. Factors that cause premature birth may have an impact on the development of the premature infant's brain both during pregnancy and later on after birth. A project conducted as part of the Academy of Finland Research Programme on Neuroscience (NEURO) is concerned to study brain growth and development invery premature or low-weight infants.

27 Aug 2008

Codeine use may be risky for some breastfeeding mothers

Using pain treatments which contain codeine may be risky for some breastfeeding mothers, according to researchers at The University of Western Ontario, and the Hospital for Sick Children (SickKids) in Toronto.

20 Aug 2008

Scientists identify several hundred genes that impact West Nile virus infection

Screening the entire human genome, a team headed by Yale University scientists have identified several hundred genes that impact West Nile virus infection. The findings reported Wednesday online in the journal Nature may give scientists valuable new clues about ways to intervene in a host of deadly viral infections.

6 Aug 2008

Twenty percent of British adult survivors of childhood cancer smoke despite hazards

Twenty percent of British adult survivors of childhood cancers are current smokers, and nearly a third have been regular smokers at some point in their lives, according to a study in the July 29 online issue of the Journal of the National Cancer Institute.

29 Jul 2008