Central Nervous System News and Research

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Variability in weight and drug content of split tablet may put patients at risk of receiving wrong dosage

Back and neck pain sufferers who divide the most frequently prescribed muscle relaxant may be getting anywhere from half to one-and-a-half times the amount of medicine they believe they are taking, suggests a new study examining the practice of tablet splitting.

19 May 2004

Managing large numbers of patients from mass casualty incidents

Today’s hospitals are challenged to become better prepared to manage large numbers of patients from mass casualty incidents (MCI), hazardous material incidents (HAZMAT), or in extreme cases, attacks using weapons of mass destruction (WMD).

17 May 2004

Study of hematopoietic stem cell transplantation for severe, treatment-resistant lupus

The study will include a basic research component to examine the roles of B and T cells, white blood cells in the immune system, in triggering lupus symptoms.

14 May 2004

Cholesterol-lowering drugs could treat multiple sclerosis

Drug treatments for MS are expensive and only partially effective. Recent knowledge that statins promote an anti-inflammatory response from the immune system suggest a potential in the treatment of MS.

13 May 2004

Botswana begins massive emergency polio campaign

The Minister of Health of Botswana today kicked off a massive emergency immunization campaign in the southern African nation of Botswana, following the re-introduction of poliovirus into the country from Nigeria in February.

10 May 2004

Mad cow sent to slaughterhouse

On Friday, April 30th, the Food and Drug Administration learned that a cow with central nervous system symptoms had been killed and shipped to a processor for rendering into animal protein for use in animal feed.

7 May 2004

New figures suggest Scotland is in the middle of a mumps epidemic

New figures raise public fears of a mumps epidemic by showing there were 370 confirmed cases of mumps in the first four months of 2001. This figure is almost an 800% increase on the total of recorded mumps cases for the whole of 2003.

3 May 2004

Botox helps children with cerebral palsy

Botox, or botulinum toxin, offers a new, non-surgical option for improving the upper extremity function of children with cerebral palsy (CP), report researchers from Wake Forest University Baptist Medical Center. L. Andrew Koman, M.D., orthopedic surgeon at Brenner Children’s Hospital, and his team recently completed a study using Botox to treat muscle spasticity of the arm and hand in children with CP.

1 May 2004

Functional genomics and proteomics may accelerate the discovery of new drugs and therapeutic molecules

Functional genomics and proteomics have been quite successful in identifying functions of potential therapeutic targets such as encoded proteins. In fact, the possibilities of identifying more than 10,000 novel target antigens in the human genome may accelerate the discovery of new drugs and therapeutic molecules.

29 Apr 2004

Transplanted bone-marrow cells could regenerate nerve cells in the brain

Findings of a preliminary study in this week's issue of THE LANCET suggest that transplanted adult bone-marrow cells could regenerate nerve cells in the brains of human stem-cell recipients. These early findings, if confirmed in future research, have implications for the treatment of neurodegenerative disorders such as Parkinson's disease.

29 Apr 2004

Researchers show that language “center” of brain shifts with age

Along with left- or right-handedness, the hemisphere of the brain where language capacity resides is likely predetermined. Researchers have now shown that with age, language capacity in the brain becomes more evenly distributed between hemispheres.

27 Apr 2004

The April 2004 issue of Otolaryngology focuses on head and neck surgery

The efficacy of a new cancer-fighting virus is tested in the study, “Treatment of Solid Sarcomas in Immunocompetent Mice with Novel Oncolytic Herpes Simplex Viruses.” A team of multi-disciplinary Japanese researchers found that a weakened version of herpes simplex virus (HSV) effectively eradicated neck and flank tumors in mice.

23 Apr 2004

Functional genomics provide improved drug discovery

Functional genomics and proteomics have been quite successful in identifying functions of potential therapeutic targets such as encoded proteins.

20 Apr 2004

Myriad Genetics advances drug for chemotherapy-induced nausea

Myriad Genetics, Inc. today released new data on MPC-4505, its Neurokinin-1 (NK1) receptor antagonist, a drug candidate for chemotherapy-induced nausea and vomiting (emesis). MPC-4505 is a potent, orally bioavailable, CNS-penetrating, highly selective NK1 antagonist.

20 Apr 2004

Chinese mushrooms can improve physical well-being

Nutritionists have since joined with manufacturers to produce supplements using fermentation from this rare mushroom. One such product is CordyMax®, made with a formula recognized in China as the fermented Cordyceps mushroom mycelial product. CordyMax® has been placed under intellectual property protection, and only one company has the license for it outside of China.

19 Apr 2004

Curry offers possible protection against Alzheimer’s disease

A new study has found that curry, a common and popular cooking additive, could be an effective enhancer of an enzyme that protects the brain against oxidative conditions.

19 Apr 2004

Using mass spectrometry to diagnose cancers and non-cancerous diseases

Using mass spectrometry, Emory University scientists have identified specific protein fingerprints in the cerebrospinal fluid (CSF) of humans that enable them to differentiate between cancers, both primary and metastatic, and non-cancerous diseases of the central nervous system (CNS).

18 Apr 2004

Caffeine and children, some sound advice

Many adults are dependent on the caffeine in their morning coffee to get them going. But what about kids? Children who regularly drink soda, iced tea and other caffeine-containing beverages and foods may be getting too much. Find out how caffeine can be bad for your kids (and you) -- and how much is too much.

16 Apr 2004

Citrus soda culprit in patient’s medical mystery

It took a team of medical sleuths at Vanderbilt University Medical Center to get to the bottom of what was causing the 35-year-old to have abnormal blood chemistries during a post-transplant check up.

16 Apr 2004

New research findings in study of Rett Syndrome

Rudolf Jaenisch of the Whitehead Institute of Biomedical Research in Cambridge, MA reports in the April 6, 2004 online issue of the Proceedings of the National Academy of Sciences that introduction of the MeCP2 protein into post-mitotic nerve cells of MeCP2 mutant mice rescues the symptoms of Rett Syndrome. This raises the possibility that neurons are functionally normal in a newborn child and that neural dysfunction manifests itself only later due to prolonged MeCP2 deficiency. If correct, therapeutic strategies aimed at preventing the onset of Rett symptoms could be initiated at birth.

7 Apr 2004