Chagas Disease News and Research

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Chagas (pronounced SHA-gus) disease is named after the Brazilian physician Carlos Chagas, who discovered it in 1909. It is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors that are found only in the Americas (mainly, in rural areas of Latin America where poverty is widespread). Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis.

People can become infected in various ways. In Chagas-endemic areas, the main way is through vectorborne transmission. The insect vectors are called triatomine bugs. These blood-sucking bugs get infected by biting an infected animal or person. Once infected, the bugs pass T. cruzi parasites in their feces. The bugs are found in houses made from materials such as mud, adobe, straw, and palm thatch. During the day, the bugs hide in crevices in the walls and roofs. During the night, when the inhabitants are sleeping, the bugs emerge. Because they tend to feed on people’s faces, triatomine bugs are also known as “kissing bugs.” After they bite and ingest blood, they defecate on the person. The person can become infected if T. cruzi parasites in the bug feces enter the body through mucous membranes or breaks in the skin. The unsuspecting, sleeping person may accidentally scratch or rub the feces into the bite wound, eyes, or mouth.

Virginia Tech professor to receive Costa Rica's 2011 National Technology Prize

Pablo Sobrado, assistant professor of biochemistry at Virginia Tech, has been awarded Costa Rica's 2011 National Technology Prize, administered by the Ministry of Science and Technology.

16 Feb 2012

World-renowned researcher to address NTDs at UH, Feb. 10

Dr. Peter J. Hotez, an internationally recognized clinician and investigator of neglected tropical diseases and vaccine development, will be giving a lecture at the University of Houston (UH) from 3 to 4 p.m. Friday, Feb. 10. Hotez is one of many prominent scientists with broad appeal who will be hosted by UH in support of the university's health initiative. The talk is free and open to the public.

8 Feb 2012

Researchers identify fexinidazole as potential new therapy for visceral leishmaniasis

Researchers at the University of Dundee have identified fexinidazole as a possible, much-needed, new treatment for the parasitic disease visceral leishmaniasis.

3 Feb 2012

Abbott, DNDi partner to research on new treatments for NTDs

The Drugs for Neglected Diseases initiative (DNDi) and Abbott have signed a four-year joint research and non-exclusive licensing agreement to undertake research on new treatments for several of the world's most neglected tropical diseases, including Chagas disease, helminth infections, leishmaniasis and sleeping sickness.

31 Jan 2012

DWH signs collaboration agreement with CPDD

Developing World Health (DWH), a leading medical charity based in Stirlingshire, Scotland and committed to developing effective treatments for neglected tropical diseases, has signed a collaboration agreement with the internationally respected Consortium for Parasitic Drug Development (CPDD), based at The University of North Carolina at Chapel Hill.

27 Jan 2012

New pediatric formula for Chagas disease treatment developed in Brazil

"A new pediatric formulation developed in Brazil holds out hope for a cure for over 90 percent of newborn babies infected with Chagas disease, a parasitic infection endemic in 21 Latin American countries, where it kills more people every year than malaria," Inter Press Service reports.

9 Dec 2011

Fatal snakebites 'vastly underreported,' researchers report at annual ASTMH meeting

"Fatal snakebites worldwide have been vastly underreported because many die before seeking or reaching medical care, researchers" from the Biodiversity and Climate Research Centre in Frankfurt, Germany, reported on Monday at the American Society of Tropical Medicine and Hygiene's (ASTMH) annual meeting, UPI.com writes.

8 Dec 2011

Brazil's ANVISA grants registration for child-adapted formulation of benznidazole for Chagas disease

Today, at the occasion of the 4th DNDi Partners' Meeting in Rio de Janeiro, Brazil, Dr Carlos Gadelha, Secretary of Science, Technology and Strategic Products, Brazilian Ministry of Health, announced that Brazil's National Health Surveillance Agency (ANVISA) granted registration of a new paediatric dosage form of benznidazole, developed through a partnership between the Pernambuco State Pharmaceutical Laboratory (LAFEPE) of Brazil and the Drugs for Neglected Diseases initiative (DNDi).

3 Dec 2011

DNDi highlights lack of healthcare coverage for children with HIV/AIDS

Less than one-quarter (23%) of children with HIV/AIDS who need treatment are getting it, according to a report released by the World Health Organization (WHO) on the occasion of World AIDS Day.

2 Dec 2011

FDA approves Abbott's new Chagas in vitro diagnostic test

Abbott received approval from the U.S. Food and Drug Administration (FDA) for a new Chagas in vitro diagnostic test.

21 Nov 2011

Abbott receives FDA approval for new Chagas assay

The U.S. Food and Drug Administration today approved the first test for use as an additional, more specific test on human serum or plasma specimens found to be positive for antibodies to Trypanosoma cruzi.

19 Nov 2011

Largest-ever implementation study on kala-azar in Asia

A comprehensive four-year project including over 10,000 patients in clinical and pharmacovigilance studies for diagnosis and treatment of visceral leishmaniasis (VL, also known as kala-azar) in India and Bangladesh was launched by an international consortium formed last month to support control and elimination strategies in both countries, where the concentration of disease burden is among the world's highest.

7 Nov 2011

Scientists identify nicotinamidase enzyme as new drug target for Leishmaniasis

IRD scientist and their research partners recently identified the key role of nicotinamidase, an enzyme in the parasite Leishmania, essential for its survival but which does not exist in humans. The pathogen is incapable of developing in mammals In the absence of this enzyme. Specific targeting of this enzyme could lead to more effective ways of controlling this neglected tropical disease.

29 Oct 2011

Brazil to become world supplier of Chagas disease treatment

"Brazil is keen to take part in the international effort to expand access to medicines and to produce its own drugs, and will start by becoming the world supplier of medicines to treat Chagas disease," Health Minister Alexandre Padilha announced "at the World Conference on Social Determinants of Health, which opened Tuesday October 19 in Rio de Janeiro," Inter Press Service reports.

22 Oct 2011

MSF calls on Brazilian government to step up production of only drug for Chagas disease

Medecins Sans Frontieres (MSF) has called on the Brazilian government "to ensure its state-owned drug company steps up production of the only drug for Chagas disease, which affects 10 million people in Latin America," Guardian Health Editor Sarah Boseley writes in her "Global Health Blog" (10/6).

7 Oct 2011

More predictability in the chaos of infectious Chagas disease transmission

Despite what Hollywood would have you believe, not all epidemics involve people suffering from zombie-like symptoms--some can only be uncovered through door-to-door epidemiology and advanced mathematics.

28 Sep 2011

Sodium Stibogluconate & Paromomycin combination treatment for Kala azar

East Africa is fighting the worst kala azar outbreak in a decade. Collaboration across the region through the Leishmaniasis East Africa Platform (LEAP) has resulted in the development of a new combination therapy (SSG&PM) which is cheaper and nearly halves the length of treatment from a 30 day course of injections to 17 days.

26 Sep 2011

Researchers turn their attention to Chagas disease as developed countries see rise in infection rates

Chagas disease, a historically neglected tropical disease that the WHO estimates affects about 10 million people worldwide, is drawing increased attention as infection by the parasite spreads from Latin America to developed countries, such as Spain and the United States, Science reports.

20 Aug 2011

Neglected tropical diseases becoming more common in Europe, study shows

"Worm infestations, food parasites, Chagas disease, sand fly-transmitted infections and other neglected tropical diseases usually found in Africa and Asia are turning up more often in Europe, according to a new study" published recently in the International Journal of Infectious Diseases by researchers from the Sabin Vaccine Institute, the New York Times reports.

3 Aug 2011

DNDi's new drug development programme for children with HIV/AIDS

Today at the 6th International AIDS Society (IAS) Conference on HIV Pathogenesis, Treatment and Prevention, the Drugs for Neglected Diseases initiative (DNDi) announced the launch of a new drug development programme to address critical unmet treatment needs of children with HIV/AIDS.

19 Jul 2011