Chromosome 22 News and Research

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Humans normally have 46 chromosomes (23 pairs) in each cell. Two copies of chromosome 22, one copy inherited from each parent, form one of the pairs. Chromosome 22 is the second smallest human chromosome, spanning about 50 million DNA building blocks (base pairs) and representing between 1.5 percent and 2 percent of the total DNA in cells.

In 1999, researchers working on the Human Genome Project announced they had determined the sequence of base pairs that make up this chromosome. Chromosome 22 was the first human chromosome to be fully sequenced.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 22 likely contains between 500 and 800 genes.

Genes on chromosome 22 are among the estimated 20,000 to 25,000 total genes in the human genome.
Researchers identify link between genetic mutation and schizophrenia

Researchers identify link between genetic mutation and schizophrenia

Genetic risk factor for schizophrenia can disrupt connectivity at level of single neurons

Genetic risk factor for schizophrenia can disrupt connectivity at level of single neurons

New genetic data may help predict risk for end-stage kidney disease

New genetic data may help predict risk for end-stage kidney disease

Chinese SFDA approves China Medical Technologies' Leukemia BCR/ABL fusion gene detection FISH Probe

Chinese SFDA approves China Medical Technologies' Leukemia BCR/ABL fusion gene detection FISH Probe

Researchers find the genetic mutation that is linked with changes in brain development

Researchers find the genetic mutation that is linked with changes in brain development

Researchers discover genetic basis for some common congenital birth defects

Researchers discover genetic basis for some common congenital birth defects

Absence of ERK2 gene linked to birth defects

Absence of ERK2 gene linked to birth defects

Variations of MYH9 gene help explain high rate of kidney disease in African Americans

Variations of MYH9 gene help explain high rate of kidney disease in African Americans

Researchers pinpoint gene mutations responsible for 10 percent of non-familial cases of schizophrenia

Researchers pinpoint gene mutations responsible for 10 percent of non-familial cases of schizophrenia

Spontaneous mutations widespread in non-familial schizophrenia

Spontaneous mutations widespread in non-familial schizophrenia

Discovery of small molecule that disrupts Ewing's sarcoma oncogene

Discovery of small molecule that disrupts Ewing's sarcoma oncogene

Discovery of gene behind iron accumulation in brain has implications for Parkinson's, Alzheimer's

Discovery of gene behind iron accumulation in brain has implications for Parkinson's, Alzheimer's

Potential novel treatment strategy for Ewing's sarcoma

Potential novel treatment strategy for Ewing's sarcoma

Dasatinib provides significant benefit in chronic myeloid leukemia patients resistant to Gleevec

Dasatinib provides significant benefit in chronic myeloid leukemia patients resistant to Gleevec

Disruption of normal gene interaction linked to schizophrenia

Disruption of normal gene interaction linked to schizophrenia

Faulty gene may identify those at risk of schizophrenia

Faulty gene may identify those at risk of schizophrenia

Teens with missing part of a chromosome confirm genetic role in schizophrenia

Teens with missing part of a chromosome confirm genetic role in schizophrenia

Dopamine link to psychiatric and neurological disorders

Dopamine link to psychiatric and neurological disorders

Acute-leukemia sign may signal need for different therapy

Acute-leukemia sign may signal need for different therapy

Abnormal brain structure tied to spatial, numerical thinking problems when children lack part of chromosome

Abnormal brain structure tied to spatial, numerical thinking problems when children lack part of chromosome