Chromosome 4 News and Research

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Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 4, one copy inherited from each parent, form one of the pairs. Chromosome 4 spans more than 191 million DNA building blocks (base pairs) and represents more than 6 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 4 likely contains between 1,300 and 1,600 genes.

Genes on chromosome 4 are among the estimated 20,000 to 25,000 total genes in the human genome.

Women perceive color better than men

Stereotypes about the superior color sense of women may well be rooted in genetics. Brian Verrelli, a researcher at the Biodesign Institute at ASU, is co-collaborator on a study suggesting that natural genetic selection has provided women with a frequent ability to better discriminate between colors than men.

2 Sep 2004

Researchers discover that DNA fragments destroy melanoma cells

Researchers at Boston University School of Medicine have discovered that small DNA fragments or oligonucleotides that resemble the telomere (chromosome end), also called T-oligos, can cause human melanoma cells to undergo extensive apoptosis (cell death), while surviving melanoma cells become more differentiated and therefore less aggressive.

1 Sep 2004

First whole-genome survey of where three commonly used retroviruses into human DNA

Retroviruses are one of the most common vehicles for delivering therapeutic payloads via gene therapy in animal models of disease and human patients.

22 Aug 2004

Disruption of chromosome loops can lead to Beckwith-Wiedemann Syndrome

Babraham Institute scientists have identified chromosome ‘loops’ which have implications for healthy growth of babies in the womb.

17 Aug 2004

Scientists have uncovered the identity of the last of eight genes known to contribute to Bardet-Biedl syndrome

The identification of the BBS3 gene ends the search for primary BBS-causing genes in families studied for years by a team of scientists from the United States, Canada and the United Kingdom. However, the scientists are still hunting for other, less obvious genetic influences in these families.

16 Aug 2004

What is Telomere crisis?

Telomere crisis is an important early event in the development of breast cancer, and its occurrence can be identified with precision, according to recent findings by a team of scientists at the Department of Energy's Lawrence Berkeley National Laboratory and the University of California at San Francisco.

11 Aug 2004

Stanford researchers identify leukemia stem cells

A handful of leukemia cells constantly replenish the supply of cancerous cells, according to new work by Stanford University School of Medicine researchers.

11 Aug 2004

Physicians offer several promising and unique approaches to brain tumor treatment

An estimated 41,000 new cases of primary brain tumors are expected to be diagnosed in 2004, according to the American Brain Tumor Association.

5 Aug 2004

New screening technique to look for genes that change patients' responses to cancer drugs and other medications

Scientists have developed a new screening technique to help them look for genes that change patients' responses to cancer drugs and other medications.

3 Aug 2004

Twin research reveals gene that may play a crucial part in the development of myopia

New research carried out by doctors in the Twin Research Unit at St Thomas’ Hospital, London, indicates that a gene called PAX6 may play a crucial part in the development of myopia.

31 Jul 2004

Further evidence about how estrogen helps activate breast cancer

A UC Irvine researcher has found a novel tumor- suppressor function for a gene that, when mutated, often triggers breast cancer in women.

29 Jul 2004

Possible inherited component for lung cancer

Researchers have discovered a possible inherited component for lung cancer, a disease normally associated with external causes, such as cigarette smoking.

27 Jul 2004

Gene responsible for infertility

A paper describing discoveries about the role of a gene that is important in all animals, plants, and fungi is published in the 20 July 2004 issue of the journal Proceedings of the National Academy of Sciences.

23 Jul 2004

U.S. scientists have found the genetic basis for one form of sudden infant death syndrome

Sudden infant death syndrome, also known as cot death and crib death, is defined as the death of an infant between the ages of one month and one year which remains unexplained after a thorough postmortem, investigation of the death scene and review of the clinical history.

20 Jul 2004

DNA left overs, new mechanism for evolution

A team of researchers from the Universitat Autònoma de Barcelona (UAB) has discovered that transposons, small DNA sequences that travel through the genomes, can silence the genes adjacent to them by inducing a molecule called antisense RNA.

16 Jul 2004

Ghrelin may help reduce obsesity in children with genetic disorder

What if your child’s overeating was so uncontrollable that it led to eating out of the garbage, ransacking the kitchen and getting arrested for stealing food?

15 Jul 2004

Geographic variations in colour perception

It's long been known that color blindness is caused, usually in men, by changes in the red and green opsin genes, the genes that enable humans to perceive color.

9 Jul 2004

How DNA repair machinery detects and corrects errors in DNA replication

Biochemists at Duke University Medical Center have discovered key components that enable the cell's DNA repair machinery to adeptly launch its action in either direction along a DNA strand to strip out faulty DNA.

2 Jul 2004

Chromosomal chaos in early embryonic development is linked to abnormalities in cytokinesis and spindle formation

Abnormalities in the spindles (the bi-polar thread like structures that link and pull the chromosomes during cell division) of human embryos before implantation may be the primary reason for many of the chromosome defects observed in early human development

29 Jun 2004

A moderately high protein diet could reduce a woman’s chances of becoming pregnant

A moderately high protein diet could reduce a woman’s chances of becoming pregnant, according to new research presented at the 20th annual conference of the European Society of Human Reproduction and Embryology today on Monday 28 June.

28 Jun 2004