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First-in-class oral drug improves embryo implantation and pregnancy outcomes in IVF

New research has demonstrated the effectiveness of a first-in-class oral, non-hormonal drug in increasing embryo implantation, pregnancy and live birth rates among infertile women who are undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).

8 Jul 2024

Small molecule discovery offers hope for treatment of Angelman syndrome

Angelman syndrome is a rare genetic disorder caused by mutations in the maternally-inherited UBE3A gene and characterized by poor muscle control, limited speech, epilepsy, and intellectual disabilities.

8 Jul 2024

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, has successfully delivered the second preclinical candidate compound (PCC) in its collaboration with Fosun Pharma in June 2024, a potential innovative therapeutic using synthetic lethal strategy for the treatment of solid tumors.

5 Jul 2024

Novel compound amplifies naloxone's power to reverse overdoses

In a Stanford Medicine-led study, researchers combed through billions of compounds to find one that could enhance naloxone’s ability to fend off more potent opioids, with promising results in mice.

4 Jul 2024

Monocyte signature predicts dexamethasone response in severe COVID-19 patients

Dexamethasone is one of the most important drugs in the treatment of severe COVID-19, but patients respond very differently to the therapy.

3 Jul 2024

Researchers identify potential drugs that make naloxone more potent and longer lasting

The ongoing opioid epidemic in the U.S. kills tens of thousands of people every year. Naloxone, sold under the brand name Narcan, has saved countless lives by reversing opioid overdoses.

3 Jul 2024

PVP-037: A novel imidazopyrimidine adjuvant enhancing vaccine immune responses

Many vaccines are only partially effective, have waning efficacy, or do not work well in the very young or the very old.

3 Jul 2024

Welch Foundation funds UTA’s research into creating new materials for effective drug delivery

With a $300,000 grant, the Welch Foundation is supporting University of Texas at Arlington research into creating new materials to safely and effectively deliver medications to treat diseases such as cancer.

2 Jul 2024

Visible light technique simplifies synthesis of key pharmaceutical building blocks

University of Michigan chemists have discovered a way to use visible light to synthesize a class of compounds particularly well suited for use in pharmaceuticals.

2 Jul 2024

Study hints at a promising approach for treating wet age-related macular degeneration

A new study in mice hints at the promise of an eventual alternative treatment option for the "wet" version of age-related macular degeneration (AMD).

2 Jul 2024

Optibrium demonstrates accelerated lead optimization in complex agrochemical development

Optibrium, a leading developer of software and AI solutions for molecular design today announced the publication of a peer-reviewed study in Journal of Computer-Aided Molecular Design, ‘From UK-2A to florylpicoxamid: Active learning to identify a mimic of a macrocyclic natural product’

From Optibrium Ltd. 2 Jul 2024

Ethanolic extracts from olive leaves show promise in combating cancer and infections

A recent study in Antioxidants reveals that ethanolic extracts from Greek and Spanish olive leaves exhibit high antioxidant, antimicrobial, and anticancer properties, with Greek extracts showing greater efficacy. This suggests potential healthcare applications, particularly as antimicrobial agents and melanoma treatments.

30 Jun 2024

Natural compound found in olives can lower blood sugar levels and promote weight loss

Findings from a new mouse study suggest that elenolic acid, a natural compound found in olives, can lower blood sugar levels and promote weight loss.

29 Jun 2024

Serotonin 2C receptor in the brain regulates memory in people and animal models, research shows

Researchers at Baylor College of Medicine, the University of Cambridge in the U.K. and collaborating institutions have shown that serotonin 2C receptor in the brain regulates memory in people and animal models.

28 Jun 2024

Novel approach can make many more bacteria amenable to genetic engineering

Bacteria possess unique traits with great potential for benefiting society. However, current genetic engineering methods to harness these advantages are limited to a small fraction of bacterial species.

26 Jun 2024

Study sheds light on the intricate relationship between depression and brain activity

A significant new study published in the Cyborg Bionic Systems journal by Fanli Kong and colleagues sheds light on the intricate relationship between depression and brain activity, particularly focusing on the basolateral amygdala (BLA) in rats.

26 Jun 2024

Dietary fiber promotes beneficial conversion of tryptophan by gut bacteria

We get healthy dietary fibres from consuming fruits, vegetables, and whole grains. But why are the fibres so good for us? A team of researchers has discovered that dietary fibres play a crucial role in determining the balance between the production of healthy and harmful substances by influencing the behavior of bacteria in the colon.

26 Jun 2024

Nitrate from plant sources linked to lower risk of mortality

New research from Edith Cowan University (ECU) has found that nitrate from plant sources is associated with a lower risk of mortality while nitrate from other sources such as animal-based foods, processed meat and tap water, is linked to a higher risk of mortality.

25 Jun 2024

Mouse studies suggest gestational CBD exposure alters offspring behavior and brain function

Cannabidiol (CBD), one of the active ingredients in cannabis, is thought to be safe as it does not cause a "high".

24 Jun 2024

Advances in Diels-Alder synthesis of hydrocarbazole compounds using lanthanide catalysts

Hydrocarbazole is a crucial compound in organic chemistry, serving as a building block for various biologically active compounds, including pesticides like strychnine and anticancer drugs such as vinblastine and minovincine.

24 Jun 2024

Compound News and Research

First-in-class oral drug improves embryo implantation and pregnancy outcomes in IVF

Small molecule discovery offers hope for treatment of Angelman syndrome

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Novel compound amplifies naloxone's power to reverse overdoses

Monocyte signature predicts dexamethasone response in severe COVID-19 patients

Researchers identify potential drugs that make naloxone more potent and longer lasting

PVP-037: A novel imidazopyrimidine adjuvant enhancing vaccine immune responses

Welch Foundation funds UTA’s research into creating new materials for effective drug delivery

Visible light technique simplifies synthesis of key pharmaceutical building blocks

Study hints at a promising approach for treating wet age-related macular degeneration

Optibrium demonstrates accelerated lead optimization in complex agrochemical development

Ethanolic extracts from olive leaves show promise in combating cancer and infections

Natural compound found in olives can lower blood sugar levels and promote weight loss

Serotonin 2C receptor in the brain regulates memory in people and animal models, research shows

Novel approach can make many more bacteria amenable to genetic engineering

Study sheds light on the intricate relationship between depression and brain activity

Dietary fiber promotes beneficial conversion of tryptophan by gut bacteria

Nitrate from plant sources linked to lower risk of mortality

Mouse studies suggest gestational CBD exposure alters offspring behavior and brain function

Advances in Diels-Alder synthesis of hydrocarbazole compounds using lanthanide catalysts

E-Cigarettes and Ethanol: A forensic Perspective on Vaping

Understanding Consumer-Consented Data to Optimize Digital Health Programs

The Future is Wearable: Advancing Human Health Through Portable Spectroscopy

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