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New brain atlas reveals hidden cell vulnerabilities in Alzheimer's

Researchers created a detailed transcriptomic atlas of six brain regions, revealing cell-type-specific and region-specific vulnerabilities in Alzheimer's disease and highlighting astrocyte genes linked to cognitive resilience.

25 Jul 2024

Novel antisense therapy targets α-synuclein pathologies in neurodegenerative diseases

TMDU researchers demonstrate proof of concept of antisense nucleic acid therapy to prevent the spread of α-synuclein pathologies in synucleinopathies.

25 Jul 2024

Unprecedented brain cell mapping sheds light on Alzheimer's

Less than a decade ago, when Dr. Hansruedi Mathys launched an ambitious project to create an annotated library of all the gene readouts stored within 100 individual brain cells, the task felt daunting.

25 Jul 2024

Oligodendrocytes identified as key amyloid β producers in Alzheimer's disease

Researchers discovered that oligodendrocytes, not just neurons, produce amyloid β in Alzheimer's disease, and suppressing their activity improves disease pathology. This finding suggests new therapeutic targets for Alzheimer's treatment.

24 Jul 2024

Neuroscientists discover a key piece of the placebo effect puzzle

The placebo effect is very real. This we've known for decades, as seen in real-life observations and the best double-blinded randomized clinical trials researchers have devised for many diseases and conditions, especially pain.

24 Jul 2024

Studies aim to identify adolescent girls who are at risk of developing migraine headaches

A migraine is not just a bad headache. It is a much-dreaded part of a neurologic disorder that has an array of possible symptoms, including pulsating cranial pain, waves of queasiness, bouts of vomiting, and hypersensitivity to light and sound.

22 Jul 2024

Brain coupling patterns as predictive markers for psychosis in 22q11.2DS

A UNIGE team shows that overly strong or weak interconnections between certain brain areas could be a predictive marker of the disease.

22 Jul 2024

Why do we blush, and what are the underlying mechanisms of blushing? Research aims to find out

Researchers investigated the neural substrates and mental processes underlying blushing in response to self-observation.

22 Jul 2024

Study examines brain activity and time perception over minutes and hours

Ever hear the old adage that time flies when you're having fun? A new study by a team of UNLV researchers suggests that there's a lot of truth to the trope.

19 Jul 2024

Psilocybin reconfigures brain networks, showing potential for lasting therapeutic effects

Researchers found that high-dose psilocybin significantly disrupts brain functional connectivity, particularly in the default mode network, with lasting effects linked to therapeutic benefits.

18 Jul 2024

Visual cortex's impact on motor skill acquisition

You join a swing dance class, and at first you're all left feet. But – slowly, eyes glued to the teacher – you pick up a step or two and start to feel the rhythm of the big band beat. A good start.

18 Jul 2024

Novel insights into how exercise functions as an antidepressant

Researchers from University College London propose a novel framework linking reduced inflammation and boosted dopamine transmission through exercise to alleviate depressive symptoms.

18 Jul 2024

Study reveals brain structure differences in children with conduct disorder

Conduct disorder in young people is associated with differences in surface area across much of the brain compared to typically developing children, new research shows.

17 Jul 2024

New cortical surface template provides greater accuracy in analyzing neuroimaging data

The human brain is responsible for critical functions, including perception, memory, language, thinking, consciousness, and emotions.

16 Jul 2024

Allen Institute launches neuroscience initiatives on perception, recognition, and psychedelics

How do neurons react to magic mushrooms? What happens in the brain when we see motion, or when we recognize grain patterns in a piece of wood? How do our brains track the subtle changes in our friends' appearances over time?

15 Jul 2024

Study reveals altered neural signature in patients with depression

As parents, teachers and pet owners can attest, rewards play a huge role in shaping behaviors in humans and animals.

15 Jul 2024

Mechanism behind propofol-induced unconsciousness revealed

There are many drugs that anesthesiologists can use to induce unconsciousness in patients. Exactly how these drugs cause the brain to lose consciousness has been a longstanding question, but MIT neuroscientists have now answered that question for one commonly used anesthesia drug.

15 Jul 2024

Precise brain imaging method reveals origins of creativity

Have you ever had the solution for a tough problem suddenly hit you when you're thinking about something entirely different? Creative thought is a hallmark of humanity, but it's an ephemeral, almost paradoxical ability, striking unexpectedly when it's not sought out.

15 Jul 2024

Predicting behavior from image features: Insights from cortical tuning

Researchers investigate whether the human occipital-temporal cortex (OTC) co-represents the semantic and affective content of visual stimuli to guide behavior.

15 Jul 2024

Researchers identify brain region that tunes hearing to contextual needs

Have you ever noticed how you can suddenly hear your refrigerator humming in the background when you focus on it? Or how the sound of your name instantly catches your attention even in a noisy crowd?

12 Jul 2024