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eTNS therapy can impact symptoms in pharmacoresistant major depression

Earlier today, at the American Psychiatric Association Annual Meeting in Philadelphia, Dr. Ian Cook, Principal Investigator and Professor of Psychiatry at UCLA, and a Senior Medical Advisor to NeuroSigma, Inc., presented the results of a Phase Ib open-label clinical trial that studied the effects of eTNS on depressive symptoms in Major Depressive Disorder (MDD) as an adjunct to pharmacotherapy.

9 May 2012

Psychopaths’ brains differ from healthy non-offenders: Study confirms

Approximately half of male prisoners in England and Wales will meet diagnostic criteria for ASPD. The majority of such men are not true psychopaths (ASPD-P). They are characterized by emotional instability, impulsivity and high levels of mood and anxiety disorders. They typically use aggression in a reactive way in response to a perceived threat or sense of frustration.

8 May 2012

DBS may offer hope for patients with mild Alzheimer's

A study on a handful of people with suspected mild Alzheimer's disease (AD) suggests that a device that sends continuous electrical impulses to specific "memory" regions of the brain appears to increase neuronal activity. Results of the study using deep brain stimulation, a therapy already used in some patients with Parkinson's disease and depression, may offer hope for at least some with AD, an intractable disease with no cure.

8 May 2012

Awake mental replay essential for making informed choices

Awake mental replay of past experiences is essential for making informed choices, suggests a study in rats. Without it, the animals- memory-based decision-making faltered, say scientists funded by the National Institutes of Health. The researchers blocked learning from, and acting on, past experience by selectively suppressing replay - encoded as split-second bursts of neuronal activity in the memory hubs of rats performing a maze task.

4 May 2012

Researchers investigate hydrogels' potential in drug delivery

The flexible properties of hydrogels - highly absorbent, gelatinous polymers that shrink and expand depending on environmental conditions such as humidity, pH and temperature - have made them ideal for applications from contact lenses to baby diapers and adhesives.

4 May 2012

Dopamine linked to willingness to work for a monetary reward

A new brain imaging study has shown that an individual’s willingness to work hard to earn money is strongly influenced by the chemistry in three specific areas of the brain. Researchers claim that this could have important implications for the treatment of attention-deficit disorder, depression, schizophrenia and other forms of mental illness characterized by decreased motivation.

3 May 2012

Paper explores links between neuronal avalanches and spike time-dependent plasticity

The brain's neurons are coupled together into vast and complex networks called circuits. Yet despite their complexity, these circuits are capable of displaying striking examples of collective behavior such as the phenomenon known as "neuronal avalanches," brief bursts of activity in a group of interconnected neurons that set off a cascade of increasing excitation.

3 May 2012

Human study suggests biological basis for individual differences in behavior

Whether someone is a "go-getter" or a "slacker" may depend on individual differences in the brain chemical dopamine, according to new research in the May 2 issue of The Journal of Neuroscience. The findings suggest that dopamine affects cost-benefit analyses.

2 May 2012

Teenage risky behaviors can be traced to special brain wiring: Study

New research suggests that there is a complex networks of neurons in some youngsters’ brains that make them more likely to begin smoking, experimenting with cannabis or consuming large amounts of alcohol.

30 Apr 2012

Scientists discover number of unknown brain networks linked with teen drug abuse

Why do some teenagers start smoking or experimenting with drugs-while others don't? In the largest imaging study of the human brain ever conducted-involving 1,896 14-year-olds-scientists have discovered a number of previously unknown networks that go a long way toward an answer.

30 Apr 2012

Brain scans of small group of people can predict actions of entire populations

Brain scans of a small group of people can predict the actions of entire populations, according to a new study by researchers from the University of Michigan, the University of Oregon and the University of California at Los Angeles.

26 Apr 2012

Study uses brain data to predict how large populations will respond to ads

Advertisers and public health officials may be able to access hidden wisdom in the brain to more effectively sell their products and promote health and safety, UCLA neuroscientists report in the first study to use brain data to predict how large populations will respond to advertisements.

26 Apr 2012

Neuron-killing pathology of AD requires presence of a-beta and elevated p-tau levels

According to a new study, the neuron-killing pathology of Alzheimer's disease (AD), which begins before clinical symptoms appear, requires the presence of both amyloid-beta (a-beta) plaque deposits and elevated levels of an altered protein called p-tau.

24 Apr 2012

Chronic cocaine abuse accelerates process of brain ageing

New research by scientists at the University of Cambridge suggests that chronic cocaine abuse accelerates the process of brain ageing. The study, published today 25 April in Molecular Psychiatry, found that age-related loss of grey matter in the brain is greater in people who are dependent on cocaine than in the healthy population.

24 Apr 2012

Exercise staves off dementia in older women: Study

Older women with first signs of memory decline might ward off full-blown dementia by engaging in routine strength training according to a new study. However supervised weight-lifting seems to be working better than aerobics-based activity programs, the study found. The study was conducted with researchers from the Department of Psychology and Division of Geriatric Medicine at UBC, and Department of Psychology at the University of Iowa.

24 Apr 2012

TopBP1 protein prevents early brain cells from DNA damage

St. Jude Children's Research Hospital scientists have rewritten the job description of the protein TopBP1 after demonstrating that it guards early brain cells from DNA damage. Such damage might foreshadow later problems, including cancer.

24 Apr 2012

Breakdown of white-matter pathways affects decision-making as we age

If you are an aging baby boomer and you've noticed it's a bit harder to drive to unfamiliar locations or to pick a new brand of olive oil at the supermarket, you can blame it on the white matter in your brain.

20 Apr 2012

Therapeutic hypothermia reduces in-hospital deaths among sudden cardiac arrest patients

Forced body cooling known as therapeutic hypothermia has reduced in-hospital deaths among sudden cardiac arrest patients nearly 12 percent between 2001 and 2009, according to a Mayo Clinic study being presented at the upcoming American Academy of Neurology 2012 Annual Meeting in New Orleans.

20 Apr 2012

UCSF scientists solve mystery of how selective hearing works

The longstanding mystery of how selective hearing works - how people can tune in to a single speaker while tuning out their crowded, noisy environs - is solved this week in the journal Nature by two scientists from the University of California, San Francisco.

19 Apr 2012

First neurobiological model for third-party punishment

In a paper published online on April 15 by the journal Nature Neuroscience, a pair of neuroscientists from Vanderbilt and Harvard universities has proposed the first neurobiological model for third-party punishment. It outlines a collection of potential cognitive and brain processes that evolutionary pressures could have re-purposed to make this behavior possible.

19 Apr 2012