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Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia.

9 Apr 2024

Network analysis reveals subtle changes associated with subjective cognitive decline

We all lose our car keys or our glasses from time to time. Most people would be correct to laugh it off as a normal part of aging.

9 Apr 2024

New ovarian atlas paves the way for extended fertility and hormone restoration

A new "atlas" of the human ovary provides insights that could lead to treatments restoring ovarian hormone production and the ability to have biologically related children, according to University of Michigan engineers.

5 Apr 2024

Feeling lonely? It may affect how your brain reacts to food, new research suggests

The associations between individuals’ perceived levels of social isolation and brain patterns related to food cues.

5 Apr 2024

Interferon-beta deficiency alters brain response in neuroHIV mouse model

NeuroHIV refers to the effects of HIV infection on the brain or central nervous system and, to some extent, the spinal cord and peripheral nervous system.

4 Apr 2024

Unlocking role of the cerebellum in reward-based learning

If you reward a monkey with some juice, it will learn which hand to move in response to a specific visual cue – but only if the cerebellum is functioning properly.

4 Apr 2024

Dartmouth-led research identifies unique brain areas for emotion regulation

Ever want to scream during a particularly bad day, but then manage not to? Thank the human brain and how it regulates emotions, which can be critical for navigating everyday life.

3 Apr 2024

New insights into adrenal gland tumor formation

Researchers from Kyushu University's Faculty of Medical Sciences report on new insights into the mechanisms of how adrenal gland tumors are formed.

2 Apr 2024

Using neuromorphic engineering to reinvent visual processing systems with a biological inspiration

As computer vision (CV) systems become increasingly power and memory intensive, they become unsuitable for high-speed and resource deficit edge applications - such as hypersonic missile tracking and autonomous navigation - because of size, weight, and power constraints.

1 Apr 2024

Research reveals brain morphology and connectivity changes in postmenopausal women

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 6, entitled, "Altered brain morphology and functional connectivity in postmenopausal women: automatic segmentation of whole-brain and thalamic subnuclei and resting-state fMRI."

1 Apr 2024

New imaging technique maps oxygen movement in the brain

The human brain consumes vast amounts of energy, which is almost exclusively generated from a form of metabolism that requires oxygen.

28 Mar 2024

McGovern researchers debunk claims of direct neuronal activity imaging with MRI

A new way of imaging the brain with magnetic resonance imaging (MRI) does not directly detect neural activity as originally reported, according to scientists at MIT's McGovern Institute.

27 Mar 2024

Evolving brain sizes from 1930 to 1970 could signal decreased dementia risk, researchers say

Changes in skull and brain size, as well as the thickness of the cortex, across individuals born between the years 1930 and 1970.

27 Mar 2024

Researchers explore link between tooth loss and denture usage, diet changes and cognitive decline

A recent npj Aging study assessed the specific brain regions that are impacted by tooth loss and the associated causes.

25 Mar 2024

Study shows cellular, molecular overlaps in ALS and FTLD

On the surface, the movement disorder amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the cognitive disorder frontotemporal lobar degeneration (FTLD), which underlies frontotemporal dementia, manifest in very different ways. In addition, they are known to primarily affect very different regions of the brain.

22 Mar 2024

Study explores how the brain creates a cohesive sense of body position and movement

How does your brain know the position and movement of your different body parts? The sense is known as proprioception, and it is something like a "sixth sense", allowing us to move freely without constantly watching our limbs.

21 Mar 2024

Hearing loss linked to accelerated Alzheimer's progression via GDF1 pathway

Study unveils the GDF1 signaling pathway's role in mitigating the adverse effects of hearing loss on Alzheimer's disease, spotlighting potential avenues for therapeutic development.

20 Mar 2024

Breakthrough research uncovers neural basis of odor perception

Scents, such as coffee, flowers, or freshly-baked pumpkin pie, are created by odor molecules released by various substances and detected by our noses.

18 Mar 2024

Study reveals the inner workings of gene mutations linked to ultra-rare syndrome

A team from the University of Ottawa's Faculty of Medicine has completed an exciting new study that reveals the inner workings of gene mutations that result in an ultra-rare syndrome with fewer than 100 reported cases since its first description in the early 1960s.