Corticosteroid News and Research

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Corticosteroids are any steroid hormones made in the adrenal cortex (the outer part of the adrenal gland). They are also made in the laboratory. Corticosteroids have many different effects in the body, and are used to treat many different conditions. They may be used as hormone replacement, to suppress the immune system, and to treat some side effects of cancer and its treatment. Corticosteroids are also used to treat certain lymphomas and lymphoid leukemias.

Multiple courses of prenatal corticosteroids did not increase risk of death for young children

Multiple courses of prenatal corticosteroids, compared with a single course, taken by pregnant women to help prevent preterm birth was associated with no increase or decrease in the risk of death or disability for their children at age 5, according to a study published by JAMA Pediatrics, a JAMA Network publication.

15 Oct 2013

New clinical trial shows increased asthma control with FeNO-guided anti-inflammatory treatment

A new randomised clinical trial shows lower incidence of asthma exacerbations and increased asthma control with Fractional exhaled Nitric Oxide (FeNO)-guided anti-inflammatory treatment.

11 Oct 2013

Specialty asthma care no benefit to adherence in underserved children

Results of a study of underserved children with asthma in the USA suggest that they may be losing out on the benefits of specialty care.

20 Sep 2013

Inhaled corticosteroid increases risk for pneumonia reoccurrence

A University of Alberta researcher says health professionals should be cautious about prescribing inhaled corticosteroids to high-risk patients such as pneumonia survivors, citing a twofold risk for repeat infection.

19 Sep 2013

Intra-articular hyaluronic acid injections safe, effective for patients with knee osteoarthritis

A new meta-analysis of 29 randomized studies involving more than 4,500 patients with knee osteoarthritis found that intra-articular hyaluronic acid injections provided significant improvement in pain and function compared to saline injections.

18 Sep 2013

Inhaled corticosteroids increase pneumonia risk in asthma

Research from the UK indicates that the use of inhaled corticosteroids is independently associated with an increased risk for pneumonia and lower respiratory tract infection in patients with asthma.

12 Sep 2013

Improved lung function in patients with moderate asthma severity observed with investigational Tiotropium

Boehringer Ingelheim will present a pooled analysis of new data from the Phase 3 UniTinA-asthma® program at the European Respiratory Society (ERS) Annual Congress 2013 in Barcelona. The data from the individual MezzoTinA-asthma® Phase 3 studies (NCT01340209 and NCT00565266), from which the pooled data are derived, show the addition of tiotropium delivered via the Respimat® inhaler to medium-dose maintenance inhaled corticosteroid (ICS) therapy (defined as 400-800 µg budesonide/day or equivalent) improved lung function and provided sustained bronchodilation over 24 hours in patients with moderate asthma and airflow limitation. Tiotropium is being investigated to determine the medicine’s efficacy in treating asthma patients and is not currently approved for this indication.

11 Sep 2013

Combination drug does not improve survival in patients with severe alcoholic hepatitis

Four weeks of treatment with a combination of the drug pentoxifylline and the corticosteroid prednisolone did not improve 6-month survival compared with prednisolone alone in 270 patients with severe alcoholic hepatitis, according to a study in the September 11 issue of JAMA.

11 Sep 2013

Hospira announces EC approval of Inflectra, Europe's first biosimilar mAb therapy

Hospira, the world's leading provider of injectable drugs and infusion technologies, today announced the European Commission (EC) approval of Inflectra™ (infliximab), Europe's first biosimilar monoclonal antibody (mAb) therapy. Inflectra has been approved for the treatment of inflammatory conditions including rheumatoid arthritis (RA), ankylosing spondylitis, Crohn's disease (CD), ulcerative colitis (UC), psoriatic arthritis (PsA) and psoriasis.

10 Sep 2013

Patients with COPD show improvements in lung function with olodaterol

Data from the olodaterol Phase 3 clinical program, presented for the first time at the European Respiratory Society (ERS) Annual Congress 2013 in Barcelona, showed the addition of olodaterol 5 and 10 µg delivered once daily via the Respimat® inhaler provided improvements in lung function in patients with moderate to very severe chronic obstructive pulmonary disease (COPD).

10 Sep 2013

People with severe asthma are less likely to respond to treatment

Barcelona, Spain: People with severe asthma, who are often described as 'steroid-dependent', are actually less likely to respond to the treatment they depend on, when compared to people with mild asthma.

10 Sep 2013

Bronchial thermoplasty effective in long term

Researchers have shown that the asthma-control benefits of bronchial thermoplasty remain for as long as 5 years following treatment.

9 Sep 2013

Meda signs agreement to acquire Acton Pharmaceuticals, Inc

Meda has signed an agreement to acquire the US development company Acton Pharmaceuticals, Inc. ("Acton") including the proprietary product Aerospan. Aerospan is an inhaler for the treatment of asthma that contains the active substance Flunisolide.

31 Aug 2013

Lipidor announces positive results from Phase I/IIa study of AKVANO/calcipotriol for psoriasis vulgaris

Today Lipidor announced positive results from a Phase I/IIa study investigating the efficacy and tolerability of its AKVANO/calcipotriol spray formulation for the treatment of psoriasis vulgaris, the most common form of psoriasis.

27 Aug 2013

Bacillus-derived Hyaluronic acid from Novozymes Biopharma, Hyasis®, increases in vitro drug release time from under 10 minutes to approximately 15 hours

An investigation undertaken by Novozymes Biopharma DK has shown that when the corticosteroid dexamethasone is formulated in a cross-linked Hyaluronic acid (HA) hydrogel, the drug’s in vitro release time increases from under 10 minutes to approximately 15 hours. In addition, the in vivo half-life of dexamethasone is shown to plateau with stable dexamethasone concentration up to four hours after injection.

22 Jul 2013

Combination therapy during cardiac arrest results in improved hospital discharge and neurological status

Among patients who experienced in-hospital cardiac arrest requiring vasopressors (drugs that increase blood pressure), use of a combination therapy during cardiopulmonary resuscitation resulted in improved survival to hospital discharge with favorable neurological status, according to a study in the July 17 issue of JAMA.

17 Jul 2013

Research: Corticosteroid injections may speed-up return time for NFL players with high ankle sprains

Corticosteroid injections may speed-up the return time for National Football League players suffering high ankle sprains, according to research presented today at the American Orthopaedic Society for Sports Medicine's Annual Meeting in Chicago, IL.

12 Jul 2013

First clinical study for development of SGX203 to treat pediatric Crohn's disease

Soligenix, Inc. (Soligenix or the Company), a clinical stage biopharmaceutical company focused on developing products to treat inflammatory diseases and biodefense countermeasures where there remains an unmet medical need, announced today that it has enrolled and treated all patients in the Phase 1 Study BDP-PCD-01; the first clinical study for development of SGX203 (oral beclomethasone 17,21-dipropionate or oral BDP) for the treatment of pediatric Crohn's disease.

1 Jul 2013

Chemical hormone released due to stress can trigger mechanism for late onset of Alzheimer's disease

A chemical hormone released in the body as a reaction to stress could be a key trigger of the mechanism for the late onset of Alzheimer's disease, according to a study by researchers at Temple University.

20 Jun 2013

Study shows patients with avascular necrosis have turned to stem cell therapy for aid

Stem cells have long been touted as the next big thing. Well just maybe, it is here. According to Dr. Dennis Lox, some patients with a disorder of the bone called avascular necrosis (AVN), have turned to stem cell therapy for aid.

15 Jun 2013

Corticosteroid News and Research

Multiple courses of prenatal corticosteroids did not increase risk of death for young children

New clinical trial shows increased asthma control with FeNO-guided anti-inflammatory treatment

Specialty asthma care no benefit to adherence in underserved children

Inhaled corticosteroid increases risk for pneumonia reoccurrence

Intra-articular hyaluronic acid injections safe, effective for patients with knee osteoarthritis

Inhaled corticosteroids increase pneumonia risk in asthma

Improved lung function in patients with moderate asthma severity observed with investigational Tiotropium

Combination drug does not improve survival in patients with severe alcoholic hepatitis

Hospira announces EC approval of Inflectra, Europe's first biosimilar mAb therapy

Patients with COPD show improvements in lung function with olodaterol

People with severe asthma are less likely to respond to treatment

Bronchial thermoplasty effective in long term

Meda signs agreement to acquire Acton Pharmaceuticals, Inc

Lipidor announces positive results from Phase I/IIa study of AKVANO/calcipotriol for psoriasis vulgaris

Bacillus-derived Hyaluronic acid from Novozymes Biopharma, Hyasis®, increases in vitro drug release time from under 10 minutes to approximately 15 hours

Combination therapy during cardiac arrest results in improved hospital discharge and neurological status

Research: Corticosteroid injections may speed-up return time for NFL players with high ankle sprains

First clinical study for development of SGX203 to treat pediatric Crohn's disease

Chemical hormone released due to stress can trigger mechanism for late onset of Alzheimer's disease

Study shows patients with avascular necrosis have turned to stem cell therapy for aid

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Expanding research and clinical options for children with cancer

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