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Unlocking the potential of melatonin: A promising epigenetic weapon against cancer

Melatonin, a hormone derived from the pineal gland, has diverse effects on cellular processes. This review explores its potential role as an epigenetic regulator, particularly in modulating DNA methylation, and suggests its use in combination therapy as a novel anticancer strategy.

30 May 2023

New tool launched to make ESMO Clinical Practice Guidelines easier to use in routine clinical practice

ESMO, the leading professional organization for medical oncology, today announced the launch of a new tool designed to make the renowned ESMO Clinical Practice Guidelines (CPGs) easier to use in oncologists' routine clinical practice and support optimal decision-making in a rapidly evolving medical field.

10 May 2023

A novel species of dependoparvovirus has been identified in monk parakeets in Madrid

A novel dependoparvovirus identified from 28 healthy monk parakeets from urban regions of Spain.

30 Mar 2023

Age-induced methylation changes in the sperm epigenome contribute to offspring's medical problems

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "Age-related methylation changes in the human sperm epigenome."

21 Mar 2023

Machine learning applications for the diagnosis, treatment and prognosis of cancer

Researchers review the application of machine learning in improving cancer diagnosis, treatment, and prognosis.

19 Mar 2023

How maternal obesity and gestational diabetes can impact DNA methylation in infants

A study published in the journal Cardiovascular Diabetology describes that maternal obesity and gestational diabetes can induce epigenetic remodeling in infants, potentially impacting metabolic and developmental pathways.

6 Mar 2023

Maternal obesity associated with adverse metabolic health outcomes in childhood

Research by the University of the Basque Country indicates that changes caused by maternal obesity could lead to adverse health outcomes in childhood.

3 Mar 2023

Neutral or awkward behavior of mothers with infants linked to an epigenetic change in children

Adding evidence to the importance of early development, a new study links neutral maternal behavior toward infants with an epigenetic change in children related to stress response.

2 Mar 2023

Study may elucidate metformin's potential role in longevity through DNA methylation

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 3, entitled, "Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity."

22 Feb 2023

Novel COVID-19 protein component vaccine elicits durable immune response in rodents

Researchers describe a novel SARS-CoV-2 spike protein component vaccine called MT-001.

9 Feb 2023

A single base-resolution sequencing methodology that sequences the two most common cytosine modifications in a single workflow

Researchers developed a WGS method that read four canonical DNA bases, viz., adenine (A), cytosine (C), guanine (G), and thymine (T) plus 5mC and 5hmC, epigenetic variants of unmodified C to yield an accurate six-letter digital readout in a single workflow.

9 Feb 2023

Researchers identify potent pan-sarbecovirus antibodies from non-human primates vaccinated with an AS03 adjuvanted subunit SARS-CoV-2 vaccine

Researchers assessed the effectiveness of pan-sarbecovirus-neutralizing antibodies against SARS-CoV-2.

24 Jan 2023

Research explores the utility of epigenetically predicted BMI

DNA methylation is an accurate predictor of current BMI and a poor predictor of future BMI.

18 Jan 2023

The main source of editing of the mpox virus genome during the 2022 outbreak

Researchers investigated the main source of editing of the 2022 mpox virus genome.

11 Jan 2023

COVID-19 vaccine potency and breadth improved by nanoparticle-conjugated adjuvants

In a recent study posted to bioRxiv*, researchers designed a nanoparticle (NP)-conjugated toll-like receptor 9 (TLR9) agonist to improve the adjuvanticity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.

8 Jan 2023

Researchers report the development of robust candidate single immunization PNP hydrogel COVID vaccines

Researchers developed a one-dose subunit vaccine for the induction of durable, potent, and broad immunity against SARS-CoV-2.

16 Dec 2022

Colorectal cancer doesn’t wait - DNA methylation tests facilitate earlier treatment

In this interview, Yantao Li and Zhe Wang, Director of Cancer Early Screening Products and the Product Director of Oncology at BGI Genomics, talks to NewsMedical about colorectal cancer (CRC), including why incidences are important and the importance of screening.

From BGI Genomics 6 Dec 2022

NUS scientists develop novel low-cost method of testing for cancers

Scientists from the National University of have discovered a novel low-cost method of testing for cancers.

5 Dec 2022

Phase 2/3 clinical trial shows that Clover’s vaccine candidate reduces household transmission of SARS-CoV-2

Clover Biopharmaceuticals, Ltd., a global clinical-stage biotechnology company developing novel vaccines and biologic therapeutics, and the International Vaccine Institute, an international nonprofit organization devoted to providing vaccines critical to global public health and based in Seoul, Korea, today announced that Clinical Infectious Diseases has published additional data from SPECTRA, a global Phase 2/3 clinical trial, that showed vaccination with SCB-2019 (CpG 1018/Alum) reduced the risk of transmitting SARS-CoV-2 infection to household members, compared to placebo participants.

30 Nov 2022

Evaluating cell-free DNA-based blood tests for early detection of multiple cancers

Researchers assessed several approaches for a circulating cell-free deoxyribonucleic acid (cfDNA)-based multi-cancer early detection (MCED) test. Defining the clinical limit of detection (LOD) based on circulating tumor allele fraction (cTAF) enables the comparison of different approaches.

21 Nov 2022