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Understanding the epigenetic regulation of hepatic stellate cells in NAFLD

Non-alcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide, affecting approximately 38% of the global population from 2016 to 2019.

25 Jul 2024

Innovative array targets methylation in imprinted genes, simplifies epigenetic research

Researchers from North Carolina State University have developed an array that assesses methylation levels of genes located in imprint control regions (ICRs) within the human genome.

25 Jul 2024

New insights into how genetic variants influence disease risk

A new study by scientists at deCODE Genetics, a subsidiary of Amgen, shows that sequence variants drive the correlation between DNA methylation and gene expression. The same variants are linked to various diseases and other human traits.

25 Jul 2024

Optimizing influenza vaccine strategies with nanoparticle immunization

To offer cross-protection against diverse influenza virus variants, nanoparticle vaccines can produce pivotal cellular and mucosal immune responses that enhance vaccine efficacy and broaden protection, according to a study by researchers in the Institute for Biomedical Sciences at Georgia State University.

11 Jul 2024

Harnessing post-translational modifications for a tuberculosis booster vaccine

Tuberculosis is still one of the deadliest infectious diseases, causing over one million deaths each year worldwide.

19 Jun 2024

Study unlocks the secrets of mammalian longevity through DNA methylation analysis

Researchers developed DNA methylation-based models predicting maximum lifespan, gestation, and sexual maturity across 348 mammalian species, revealing key epigenetic markers of longevity.

10 Jun 2024

Mouse study finds PFAS exposure in fathers disrupts offspring's gene expression

Research reveals that preconception exposure to PFAS in male mice alters sperm methylation and affects gene expression in the liver and fat of their offspring.

23 May 2024

Study examines association between neighborhood disadvantage and DNA methylation in brain tissue

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "The association between neighborhood deprivation and DNA methylation in an autopsy cohort."

9 May 2024

Placental DNA methylation patterns altered by pregnancy air pollution exposure, research reveals

The relationship between prenatal air pollutant exposure concentrations and changes in placental deoxyribonucleic acid (DNA) methylation.

9 May 2024

Durable lymph-node expansion improves vaccine responses against tumors

Each one of us has around 600 lymph nodes (LNs) – small, bean-shaped organs that house various types of blood cells and filter lymph fluid – scattered throughout our bodies.

6 May 2024

Study links air pollution to increased colorectal cancer risk through DNA changes

Researchers reveal how air pollution increases colorectal cancer (CRC) risk through epigenetic changes, using a large-scale study and Mendelian randomization to demonstrate ambient pollution’s impact on CRC mortality and incidence in China.

21 Apr 2024

DNA origami vaccine DoriVac paves way for personalized cancer immunotherapy

Therapeutic cancer vaccines are a form of immunotherapy in the making that could not only destroy cancer cells in patients, but keep a cancer from coming back and spreading.

15 Mar 2024

Understanding the genetic and cellular impact of smoking

It's no secret that smoking is extremely detrimental to health. Tobacco smoke contains thousands of chemicals, including carcinogens, increasing the risk of cancer, cardiovascular and respiratory diseases.

14 Mar 2024

Exploring the epigenetic impact of smoking across racial and ethnic groups

Smoking changes the way genes are expressed, which later contributes to the development of lung cancer and other smoking-related illnesses.

1 Mar 2024

Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Researchers developed an engineered transcriptional repressor that durably silences the Pcsk9 gene in mice, reducing cholesterol levels for up to a year with a single treatment, showcasing a potential breakthrough in genetic disorder treatments without the risks of DNA mutation.

29 Feb 2024

Study reveals distinct molecular features of proximal and distal colon cancers

The colon is often thought of as one organ, but the right and left parts of the colon have different molecular features in cancers.

27 Feb 2024

New clinical practice guideline offers evidence-based recommendations for managing inhalant allergies with immunotherapy

The American Academy of Otolaryngology–Head and Neck Surgery Foundation published the Clinical Practice Guideline: Immunotherapy for Inhalant Allergy today in Otolaryngology–Head and Neck Surgery.

26 Feb 2024

New epigenetic clocks distinguish aging causes and effects

What causes us to age? New "clocks" developed by researchers may help point to the answers. Investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, unveil a new form of epigenetic clock – a machine learning model designed to predict biological age from DNA structure.

14 Feb 2024

Smoking, infection, and BMI found to significantly sway immune response, study shows

Study reveals how smoking, CMV latent infection, and BMI significantly influence cytokine release, impacting immune response variability and potentially affecting disease risk.

14 Feb 2024

Discovery on housekeeping genetic elements reveals a novel avenue in cancer therapy

Technological advancements have enabled scientists to comprehensively explore genetic control elements, unraveling the complexities of gene activation mechanisms in our genetic code.

5 Jan 2024

CpG News and Research

Understanding the epigenetic regulation of hepatic stellate cells in NAFLD

Innovative array targets methylation in imprinted genes, simplifies epigenetic research

New insights into how genetic variants influence disease risk

Optimizing influenza vaccine strategies with nanoparticle immunization

Harnessing post-translational modifications for a tuberculosis booster vaccine

Study unlocks the secrets of mammalian longevity through DNA methylation analysis

Mouse study finds PFAS exposure in fathers disrupts offspring's gene expression

Study examines association between neighborhood disadvantage and DNA methylation in brain tissue

Placental DNA methylation patterns altered by pregnancy air pollution exposure, research reveals

Durable lymph-node expansion improves vaccine responses against tumors

Study links air pollution to increased colorectal cancer risk through DNA changes

DNA origami vaccine DoriVac paves way for personalized cancer immunotherapy

Understanding the genetic and cellular impact of smoking

Exploring the epigenetic impact of smoking across racial and ethnic groups

Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Study reveals distinct molecular features of proximal and distal colon cancers

New clinical practice guideline offers evidence-based recommendations for managing inhalant allergies with immunotherapy

New epigenetic clocks distinguish aging causes and effects

Smoking, infection, and BMI found to significantly sway immune response, study shows

Discovery on housekeeping genetic elements reveals a novel avenue in cancer therapy

E-Cigarettes and Ethanol: A forensic Perspective on Vaping

Understanding Consumer-Consented Data to Optimize Digital Health Programs

The Future is Wearable: Advancing Human Health Through Portable Spectroscopy

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