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Aspirin use associated with raised risk of heart failure

Aspirin use is associated with a 26% raised risk of heart failure in people with at least one predisposing factor for the condition.

23 Nov 2021

Advanced kidney disease associated with death for cerebral palsy patients, study reveals

Cerebral palsy and kidney disease can be deeply intertwined. In childhood, the effects of the neurodevelopmental condition – like decreased physical activity and urologic dysfunction – are risk factors for kidney disease.

17 Nov 2021

Study analyzes association between obesity and endothelial dysfunction in COVID-19 patients

In COVID-19 patients, obesity is the factor most associated with the development of endothelial dysfunction, a condition in which the blood vessels become unable to contract and relax adequately, increasing the risk of events such as heart attacks, thrombosis (blood clotting), and stroke.

15 Nov 2021

Simple risk score can help predict contrast-associated kidney injury after PCI

A new, updated risk score can help predict possible contrast-associated acute kidney injury (CA-AKI) among patients undergoing percutaneous coronary intervention (PCI), Mount Sinai researchers report.

15 Nov 2021

BioIVT to highlight the use of SCHH model to investigate drug-drug interaction of bempedoic acid

BioIVT, a leading provider of research models and services for drug and diagnostic development, is hosting a webinar in which researchers will discuss how they used a sandwich-cultured human hepatocyte (SCHH) model to investigate the drug-drug interaction (DDI) potential of bempedoic acid, a drug that was recently approved to treat hypercholesterolemia.

9 Nov 2021

Automated method shows predictive power for COVID-19 in-hospital mortality

Researchers focussed on the S-learner strategy of estimating the conditional average treatment effect.

4 Nov 2021

First investigational xenotransplantation marks a major step towards adequate organ supply

The first investigational transplant of a genetically engineered, nonhuman kidney to a human body was recently completed at NYU Langone Health—marking a major step forward in potentially utilizing an alternative supply of organs for people facing life-threatening disease.

21 Oct 2021

Characterization of circulating neutrophils from hospitalized COVID-19 patients

A new preprint deals with the characterization of neutrophil phenotypes in an attempt to provide biomarkers that can predict severe disease in patients hospitalized with COVID-19.

8 Oct 2021

Pancreatic cancer clinical trials exclude Black patients based on wide range of eligibility criteria

A simulated pancreatic cancer clinical trial screening process showed that Black patients were significantly more likely than white patients to be excluded from clinical trials for a wide range of eligibility criteria, according to results presented at the virtual 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held October 6-8, 2021.

6 Oct 2021

Elevated allostatic load may impact treatment completion and breast cancer survival outcomes

Elevated allostatic load was associated with a lower likelihood of completing chemotherapy and a lower overall survival rate in patients with lymph node-positive or high-risk lymph node-negative HER2-negative breast cancer, according to results presented at the 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held online October 6-8, 2021.

6 Oct 2021

A possible protective genetic polymorphism in COVID-19

A new study discusses the role of a mucin gene enhancer on the clinical phenotype of the COVID-19.

5 Oct 2021

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

A new review article investigates the clinical and viral characteristics, pathogenesis, as well as human genetic basis associated with COVID-19.

27 Sep 2021

NKF-ASN Task Force recommends a race-free approach to diagnose kidney disease

The National Kidney Foundation (NKF) and the American Society of Nephrology (ASN) Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Diseases has released its final report, which outlines a new race-free approach to diagnose kidney disease.

25 Sep 2021

National task force advocates removal of race from the kidney function algorithm

A national task force announced Thursday that it is recommending the immediate implementation of a new diagnostic equation for measuring kidney function, which advocates say will promote health equity and increase access to transplantation for Black patients.

24 Sep 2021

Researchers identify potential approach to eliminate race from equations to estimate kidney function

Researchers have identified an approach to remove race from equations used to estimate a person's kidney function. These equations have been criticized for potentially perpetuating racial health disparities. The findings, reported September 23 in the New England Journal of Medicine, are expected to inform National Kidney Foundation–American Society of Nephrology Task Force guidelines on evaluating kidney function.

24 Sep 2021

New report outlines a race-free approach to diagnose kidney diseases

The National Kidney Foundation and the American Society of Nephrology Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Diseases has released its final report, which outlines a new race-free approach to diagnose kidney disease.

23 Sep 2021

Altered characteristics of granulocytes in COVID-19 patients can be linked to disease severity

COVID-19 disease severity seems to be affected by the characteristics of white blood cells called granulocytes, which are part of the innate immune system.

23 Sep 2021

Researchers identify prediction markers which can be used to define COVID-19 severity

An estimated 14−17% of hospitalized COVID-19 patients develop a severe form of the disease, requiring oxygen support and admission to the intensive care unit.

20 Sep 2021

Blood lipid biomarkers associated with lower risk of ALS

Some blood lipid biomarkers linked to cardiovascular disease risk are also associated with a lower risk of amyotrophic lateral sclerosis (ALS) suggest the findings of a large epidemiology study published online in the Journal of Neurology Neurosurgery & Psychiatry.

14 Sep 2021

Metabolic and immune markers as tools for risk stratification and monitoring in COVID-19

In a new study posted to the medRxiv* server scientists from Weil Cornell University and Stony Brook University in New York attempted to identify the metabolic and immune markers associated with severe COVID-19 disease using high-throughput targeted nuclear magnetic resonance (NMR) spectroscopy and high-dimensional flow cytometry. This will facilitate risk stratification, monitoring, and therapeutic interventions in COVID-19 patients.