Crohn’s Disease News and Research

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New technique using patients' own modified cells could help treat Crohn's disease

A new technique using patients' own modified cells to treat Crohn's disease has been proven to be effective in experiments using human cells, with a clinical trial of the treatment expected to start in the next six months.

15 Feb 2019

Metagenomic analysis helps understand role of bacterial species in Crohn's disease

Research on gut metagenome of patients with Crohn's disease elucidates how it influences the taxonomic and functional composition of intestinal microbiota.

31 Jan 2019

Study opens new avenue for treating ulcerative colitis or Crohn's disease

An international study led by the Complutense University of Madrid (UCM) and the National Centre for Cardiovascular Research (CNIC) has found that Lactobacillus bacteria present in the intestinal microbiota interact with immune system cells to strengthen the intestinal barrier.

31 Jan 2019

Malnutrition in children with Crohn's disease linked with increased risk of surgical complications

Results of a medical records study of children with Crohn's disease by Johns Hopkins researchers have added substantial evidence for a strong and direct link between malnutrition and increased risk of surgical complications and poor outcomes.

17 Dec 2018

Cannabis oil shown to significantly improve Crohn’s disease symptoms

In the first study of its kind, cannabis oil has been shown to significantly improve the symptoms of Crohn’s disease and the quality of life of sufferers but, contrary to previous medical thinking, has no effect on gut inflammation.

23 Oct 2018

Study pinpoints new marker that can predict Crohn’s disease subtype

Crohn's disease, a chronic inflammatory condition of the intestinal tract, has emerged as a global disease, with rates steadily increasing over the last 50 years.

16 Oct 2018

Study reveals factors linked to the development of Crohn's disease

How cells talk to each other, and what they say, has long held fascination for Seema Khurana, professor of biology and biochemistry.

5 Oct 2018

Understanding immune system's balancing act could help in prevention, treatment of IBD

Australian researchers have uncovered clues in the immune system that reveal how the balance of 'good' gut bacteria is maintained. This information could help in the prevention and treatment of inflammatory bowel disease.

3 Oct 2018

New lung tissue-on-a-chip system offers rapid testing of potential anti-fibrotic treatments

Pulmonary fibrosis is one of the most common and serious types of lung disease. Now NIBIB-funded researchers have developed an in vitro lung tissue-on-a-chip system that mimics lung fibrosis, offering rapid testing of potential new anti-fibrotic treatments.

28 Aug 2018

Clinical trial to use stem cell transplants for treating Crohn's disease

A clinical trial has begun which will use stem cell transplants to grow a new immune system for people with untreatable Crohn's disease - a painful and chronic intestinal disease which affects at least 115,000 people in the UK.

6 Aug 2018

Novel PET imaging shows promise for noninvasively detecting inflammation in people with IBD

A novel positron emission tomography imaging method shows promise for noninvasively pinpointing sites of inflammation in people with inflammatory bowel disease, which includes ulcerative colitis and Crohn's disease.

4 Jun 2018

Discovery of 100 new genes may aid research into pigmentation diseases

A new study identified more than 100 genes that play a key role in determining the color of human hair. The findings may have important implications for pigmentation diseases such as melanoma.

17 Apr 2018

Artificial sweetener sucralose worsens gut inflammation in mice with Crohn's disease

In a study that has implications for humans with inflammatory diseases, researchers from Case Western Reserve University School of Medicine and colleagues have found that, given over a six-week period, the artificial sweetener sucralose, known by the brand name Splenda, worsens gut inflammation in mice with Crohn's-like disease, but had no substantive effect on those without the condition.

15 Mar 2018

Psoriasis drug also effective at reducing aortic inflammation

Ustekinumab, sold under the name Stelara, is approved by the U.S. Food and Drug Administration to treat psoriasis, psoriatic arthritis, and Crohn's Disease. Researchers wanted to know if the benefits of the drug go beyond clearing the skin.

18 Feb 2018

International research collaboration finds genetic mutation linked to Crohn's disease

A genetic mutation was found to be associated with Crohn's disease. The discovery was made by international research collaboration and was published in the prestigious journal Science Translational Medicine.

8 Feb 2018

Dysfunctional gene may be cause of Crohn's disease in some patients

This holiday season, millions of people will gather at airports ready to board planes for destinations around the world. Depending on the environment at their destination, their suitcases may be filled with sunscreen and bathing suits, or heavy parkas and mittens.

19 Dec 2017

Scientists develop new, high resolution method for identifying microbial species and strains

Scientists from the Icahn School of Medicine at Mount Sinai, Sema4, and collaborating institutions New York University and the University of Florida today published a report detailing their new, more accurate method for identifying individual microbial species and strains in a community.

13 Dec 2017

Study finds increasing incidence of inflammatory bowel disease in newly industrialized countries

Countries in Africa, Asia, the Middle East and South America have seen a rise in incidence of inflammatory bowel disease as they have become increasingly industrialized and westernized, a new study has found.

7 Dec 2017

Penn researchers single out bacterial enzyme behind gut microbiome imbalance linked to Crohn’s disease

Penn Medicine researchers have singled out a bacterial enzyme behind an imbalance in the gut microbiome linked to Crohn's disease.

16 Nov 2017

Study discovers new genetic risk loci linked to children's food allergies

What role do genes play in egg, milk, and nut allergies? A study published in Nature Communications, led by the Max Delbrück Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, has found five genetic risk loci that point to the importance of skin and mucous membrane barriers and the immune system in the development of food allergies.

24 Oct 2017