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SARS-CoV-2 receptor-binding domain-based protein subunit vaccine shows promise against multiple SARS-CoV-2 variants

Researchers described a novel protein subunit vaccine comprising the receptor-binding domain (RBD) of ancestral SARS-CoV-2 spike (S) protein, dimerized with an immunoglobulin (Ig)G1-fraction, crystallizable (Fc) domain.

11 Aug 2022

Assessing immunization capacity of vaccine platforms with DNA origami harboring SARS-CoV-2 receptor binding domain

Researchers demonstrated that vaccine frameworks containing deoxyribonucleic acid (DNA) origami possessing SARS-CoV-2 receptor-binding domain induce strong protective immunity.

8 Aug 2022

Tannins as therapeutic agents against SARS-CoV-2

Researchers reviewed tannins as therapeutic agents against SARS-CoV-2.

29 Jul 2022

Scientists identify papain-like protease inhibitor against COVID-19

In a new study, researchers identified a papain-like protease inhibitor for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

25 Jul 2022

Mustard seed extract suppresses hydrogen peroxide levels in juice products

Researchers hypothesize that proteins with low nutritional value could be effectively used for antioxidant stabilization in orange juice.

13 Jul 2022

Study opens up a new avenue for the development of selective drug therapies

Researchers at the Department of Energy's Oak Ridge National Laboratory have definitively linked the function of a specific domain of proteins important in plant-microbe biology to a cancer trigger in humans, knowledge that had eluded scientists for decades.

5 Jul 2022

UTSA chemistry professor awarded NSF grant to advance research on the body's metabolic processes

Chemistry professor Aimin Liu has been awarded a three-year, $495,000 Accomplishment-Based Renewal (ABR) grant from the National Science Foundation (NSF) to advance his research on the body's metabolic processes using an innovative method that will improve the understanding of amino acids.

1 Jul 2022

The antiviral effects of thiol drugs in COVID-19

A recent study investigated the effects of thiol drugs on SARS-CoV-2.

1 Jul 2022

SARS-CoV-2 can evade Paxlovid by multiple mechanisms

In a recent article posted to the bioRxiv* preprint server, researchers at Rutgers, the State University of New Jersey, the University of South Florida, and the Catholic University of America demonstrated that the natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) mutations result in nirmatrelvir resistance.

30 Jun 2022

Discovery suggests a new way to slow or stop metastatic spread of pancreatic cancer

Pancreatic cancer, though rare, is one of the deadliest of cancers, killing nearly 50,000 people yearly and doing so quickly, primarily because it metastasizes rapidly through the body. Barely one in 10 people survive beyond five years.

29 Jun 2022

A full model of the SARS-CoV-2 spike protein for studying its atomic-level dynamics by multiple microsecond simulations

Researchers constructed a full-length SARS-CoV-2 spike structure in its membrane-bound state to study functionally relevant aspects of its global conformational dynamics.

27 Jun 2022

Study uncovers novel treatment for chromophobe renal cell carcinoma

Chromophobe renal cell carcinoma (ChRCC) is a rare form of kidney cancer for which there are currently no proven treatments for metastatic or unresectable disease.

20 Jun 2022

The role of ARF6 in SARS-CoV-2 endocytosis and infection

Researchers assessed the role of adenoside diphosphate (ADP)-ribosylation factor 6 (ARF6) in SARS-CoV-2 infection.

14 Jun 2022

SARS-CoV-2 is a generalist virus, infecting and evolving in numerous mammals and humans

In a recent article published in the bioRxiv* preprint server, researchers illustrated zooanthroponotic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and viral mutations specific to hosts.

8 Jun 2022

De novo-designed mini-protein against SARS-CoV-2

Researchers characterized truncated forms of LCB1, a de novo-designed mini-protein, against SARS-CoV-2.

7 Jun 2022

The link between androgens and COVID-19

A new paper examines the association between androgens and COVID-19, as revealed by the research carried out on this topic throughout the pandemic.

20 May 2022

Camelid IFNs could play important role in combating emerging zoonotic pathogens

In a recent study published in the Developmental & Comparative Immunology journal, the discovery of a novel form of mammalian interferon-Beta (IFN-β) with four cysteine residues from the dromedary camel and the five remaining members of the mammalian suborder Tylopoda is described.

17 May 2022

Marine bioactive compounds against SARS-CoV-2

A new review paper published in the journal Environmental Science and Pollution Research aimed to determine the possibilities of using biologically active compounds derived from various chemical classes of marine organisms against SARS-CoV-2 infection at various stages of the life cycle of the virus.

6 May 2022

SARS-CoV-2 Mpro inhibitors built on rattlesnake venom scaffold

A new study describes the development of new molecules with inhibitory activity against the SARS-CoV-2 viral main protease (Mpro) enzyme, based on rattlesnake venom.

29 Apr 2022

Study reports an orally available SARS-CoV-2 Mpro inhibitor with potent in vivo antiviral activity

Researchers examined the efficiency of the main protease (Mpro) inhibitor against SARS-CoV-2.