Cytomegalovirus News and Research

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Cytomegalovirus (CMV) is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella-zoster virus (which causes chickenpox), and Epstein-Barr virus (which causes infectious mononucleosis). Infection with CMV is a major cause of disease and death in immunocompromised patients, including organ transplant recipients, patients undergoing hemodialysis, patients with cancer, patients receiving immunosuppressive drugs, and HIV-infected patients. While drugs are available for treatment of these conditions, the primary drug choices carry significant side effects and warnings. Currently, there are no anti-CMV drugs indicated for treatment of primary CMV infection during pregnancy resulting in infections that can have catastrophic consequences to the newborn. Maternal-fetal transfer of CMV infection results in a fetal death rate of 12% and most survivors have permanent debilitating disorders, including mental retardation, vision loss, and sensorineural deafness.

Further Reading

Vaccine for human cytomegalovirus

Vaccine for human cytomegalovirus

Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism

Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism

Key role played by Cytomegalovirus infection in the pathogenesis of atherosclerosis

Key role played by Cytomegalovirus infection in the pathogenesis of atherosclerosis

Herpes infection may be symbiotic

Herpes infection may be symbiotic

Breakthrough on cytomegalovirus transmission

Breakthrough on cytomegalovirus transmission

New drug target for herpes viruses

New drug target for herpes viruses

New drug target for herpes viruses

New drug target for herpes viruses

Experimental vector vaccine reduces stillbirths from cytomegalovirus

Experimental vector vaccine reduces stillbirths from cytomegalovirus

ViroPharma receives orphan drug designation for Maribavir

ViroPharma receives orphan drug designation for Maribavir

Innovative approach for creating a cytomegalovirus vaccine

Innovative approach for creating a cytomegalovirus vaccine

Epstein-Barr virus may trigger multiple sclerosis

Epstein-Barr virus may trigger multiple sclerosis

FDA grants fast track status for ViroPharma's Maribavir

FDA grants fast track status for ViroPharma's Maribavir

Cellular mechanism discovery could lead to new treatments for rheumatoid arthritis, multiple sclerosis and Crohn's disease

Cellular mechanism discovery could lead to new treatments for rheumatoid arthritis, multiple sclerosis and Crohn's disease

FDA grants Vical orphan-drug designation

FDA grants Vical orphan-drug designation

Association between chronic cytomegalovirus (CMV) and frailty syndrome

Association between chronic cytomegalovirus (CMV) and frailty syndrome

Research provides roadmap for the development of human therapies for cytomegalovirus (CMV)

Research provides roadmap for the development of human therapies for cytomegalovirus (CMV)

Tarvacin shows significant anti-viral activity

Tarvacin shows significant anti-viral activity

Potential cure for lymphoma in HIV patients

Potential cure for lymphoma in HIV patients

The burgeoning Indian AIDS epidemic

The burgeoning Indian AIDS epidemic

Scientists discover a record number of proteins for the highly infectious and stealthy human cytomegalovirus

Scientists discover a record number of proteins for the highly infectious and stealthy human cytomegalovirus