Cytomegalovirus News and Research

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Cytomegalovirus (CMV) is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella-zoster virus (which causes chickenpox), and Epstein-Barr virus (which causes infectious mononucleosis). Infection with CMV is a major cause of disease and death in immunocompromised patients, including organ transplant recipients, patients undergoing hemodialysis, patients with cancer, patients receiving immunosuppressive drugs, and HIV-infected patients. While drugs are available for treatment of these conditions, the primary drug choices carry significant side effects and warnings. Currently, there are no anti-CMV drugs indicated for treatment of primary CMV infection during pregnancy resulting in infections that can have catastrophic consequences to the newborn. Maternal-fetal transfer of CMV infection results in a fetal death rate of 12% and most survivors have permanent debilitating disorders, including mental retardation, vision loss, and sensorineural deafness.

Researches identify herpesvirus proteins that target key cellular processes

A study published July 11th in the open-access journal PLoS Pathogens suggests that herpesviruses use multiple strategies to manipulate important components of the host cell nuclear environment during infection.

13 Jul 2008

Ranbaxy receives tentative approval to manufacture Valganciclovir hydrochloride tablets

Ranbaxy Laboratories Limited (RLL), announced today that the company has received tentative approval from the U.S. Food and Drug Administration to manufacture and market Valganciclovir Hydrochloride Tablets, 450 mg. Total annual market sales for Valganciclovir HCl Tablets were $239 million (IMS - MAT: March 2008).

25 Jun 2008

Neglected infectious diseases go untreated, undiagnosed in hundreds of thousands of low-income residents in the U.S.

Hundreds of thousands of low-income U.S. residents in inner cities, the Mississippi Delta, Appalachia, areas near the Mexico border and tribal reservations remain undiagnosed and untreated for diseases that are prevalent in Africa, Asia and Latin America, according to an analysis published on Monday in PLoS Neglected Tropical Diseases, USA Today reports.

24 Jun 2008

Peregrine Pharmaceuticals awarded two new U.S. patents for targeted anti-aminophospholipid agents

Peregrine Pharmaceuticals, Inc. today reported the issuance of two U.S. patents that significantly broaden the company's intellectual property leadership in the field of targeted anti-aminophospholipid agents.

16 Jun 2008

Human cytomegalovirus mimics human protein to hijack cell division machinery

Viruses are masters of deception, duping their host's cells into helping them grow and spread. A new study has found that human cytomegalovirus (HCMV) can mimic a common regulatory protein to hijack normal cell growth machinery, disrupting a cell's primary anti-cancer mechanism.

8 May 2008

Poxvirus' ability to hide from the immune system may aid vaccine design

The cowpox virus, a much milder cousin of the deadly smallpox virus, can keep infected host cells from warning the immune system that they have been compromised, researchers at Washington University School of Medicine in St. Louis have found.

16 Nov 2007

Human cytomegalovirus may help doctors treat glioblastoma multiforme

A common human virus may prove useful in attacking the deadliest form of brain tumors, according to a study by researchers at Duke's Preston Robert Tisch Brain Tumor Center.

22 Oct 2007

Eight new herpes viruses discovered in bats

Scientists from the Leibniz Institute for Zoo and Wildlife Research in Berlin and colleagues detected eight new herpes viruses in bats, seven gammaherpesviruses (GHV) and one novel beta herpes virus.

25 Sep 2007

Chronic fatigue syndrome linked to enteroviruses

Chronic fatigue syndrome, also known as ME (myalgic encephalitis), is linked to a stomach virus, suggests research published ahead of print in Journal of Clinical Pathology.

13 Sep 2007

New understanding of how HSV-1 attacks cells

A team of University of Kentucky researchers has identified the roles that herpes simplex virus type 1 (HSV-1) proteins play during the invasion of cells and the formation of skin lesions known as cold sores and fever blisters.

17 Aug 2007

Gene therapy offers promising approach to tackle pancreatic cancer

A molecularly engineered therapy selectively embeds a gene in pancreatic cancer that shrinks or eradicates tumors, inhibits metastasis, and prolongs survival with virtually no toxicity, researchers from The University of Texas M. D. Anderson Cancer Center report in the July 9 edition of Cancer Cell.

10 Jul 2007

Vaccine for human cytomegalovirus

Researchers at the University of California, San Diego (UCSD) Skaggs School of Pharmacy and Pharmaceutical Sciences have patented a strategy for developing a human vaccine to prevent against Human Cytomegalovirus (hCMV) infection and disease.

23 Jun 2007

Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism

A new study conducted by researchers from the University of Verona and the Institute G. Gaslini in Genova, Italy, confirms the pivotal role played by Cytomegalovirus infection in the pathogenesis of atherosclerosis.

1 Jun 2007

Key role played by Cytomegalovirus infection in the pathogenesis of atherosclerosis

30 May 2007

Herpes infection may be symbiotic

Mice with chronic herpes virus infections can better resist the bacterium that causes plague and a bacterium that causes one kind of food poisoning, researchers report in Nature.

17 May 2007

Breakthrough on cytomegalovirus transmission

Researchers at the La Jolla Institute for Allergy & Immunology have shown that cytomegalovirus (CMV) in the salivary glands can be reduced , and in some cases eliminated , through the use of antibodies to enhance the disease-fighting power of the immune system.

11 May 2007

New drug target for herpes viruses

Scientists in the lab of Whitehead Institute Member Hidde Ploegh and the Harvard University lab of Rachelle Gaudet have solved the complex structure of a recently discovered protein that is found in a wide range of herpes viruses. This protein may prove to be a potential drug target.

11 Mar 2007

New drug target for herpes viruses

11 Mar 2007

Experimental vector vaccine reduces stillbirths from cytomegalovirus

Researchers funded by the National Institutes of Health have developed an experimental vaccine that reduces stillbirths among rodents born to mothers infected with cytomegalovirus (CMV) - a common virus that can also cause mental retardation and hearing loss in newborn children who were infected in early fetal life.

21 Feb 2007

ViroPharma receives orphan drug designation for Maribavir

ViroPharma Incorporated today announced that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation for maribavir for prevention of cytomegalovirus (CMV) viremia and disease in the populations at-risk.

7 Feb 2007