Cytomegalovirus Infection News and Research

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Stem cells give insight into path of cytomegalovirus infection

Primitive human stem cells are resistant to human cytomegalovirus, say researchers who believe this finding could provide further insight into disease pathology.

3 Dec 2012

Vanderbilt researchers receives new $2.1M grant to develop microbrain bioreactor

Take a millionth of a human brain and squeeze it into a special chamber the size of a mustard seed. Link it to a second chamber filled with cerebral spinal fluid and thread both of them with artificial blood vessels in order to create a microenvironment that makes the neurons and other brain cells behave as if they were in a living brain. Then surround the chambers with a battery of sensors that monitor how the cells respond when exposed to minute quantities of dietary toxins, disease organisms or new drugs under development.

25 Jul 2012

Hepatitis C virus (HCV)-associated liver disease after liver transplantation

Hepatitis C virus (HCV)-associated liver disease continues to be the most common indication for liver transplantation (LT) in the United States accounting for nearly 50% of all liver transplants. Recurrence is universal in patients viremic at the time of transplantation with histological hepatitis developing in the majority of patients. Although the natural history of recurrent HCV is difficult to predict, it is widely accepted that cirrhosis from recurrent HCV occurs in up to 30% of patients within five years of transplantation.

8 Jun 2011

PCR-based saliva test can accurately identify cytomegalovirus infection in newborns

Although cytomegalovirus infection is a known cause of birth defects, including permanent hearing loss, most CMV infections in infants are not identified early, when interventions can lessen the effects of hearing loss.

2 Jun 2011

Chimerix’s lipid-conjugated drugs reduces nephrotoxicity: Study

Scientists from Chimerix, Inc. today presented in vitro data demonstrating that the company's lipid-conjugated drugs, CMX001 and CMX157, are not substrates for the human Organic Anion Transporters (hOATs) and thus have significantly reduced potential to cause nephrotoxicity via this mechanism.

17 Nov 2010

Chimerix to present CMX001 data for viral infections at IDSA Annual Meeting

Chimerix, Inc., a pharmaceutical company developing orally-available antiviral therapeutics, will present promising clinical data for CMX001 in a late-breaker poster session at the Infectious Diseases Society of America (IDSA) 48th Annual Meeting.

25 Oct 2010

VBDS secondary to nevirapine use in HIV-positive, pregnant female: Report

Vanishing bile duct syndrome refers to a group of disorders characterized by destruction and disappearance of intrahepatic (inside the liver) bile ducts. Multiple causes have been identified including infections, malignancies, autoimmune conditions and adverse effects of medications. The usual course of this condition is variable and many patients with VBDS respond to treatment of the underlying condition and/ or removal of the offending agent. However, others progress to cirrhosis and end stage liver disease requiring liver transplantation.

31 Jul 2010

Universal screening test for CMV infection is not effective, says study

DNA analysis of dried blood samples routinely collected from newborns did not effectively identify an infection that is a major cause of hearing loss in children, according to a study in the April 14 issue of JAMA.

15 Apr 2010

Life-saving therapeutic interventions possible with early detection of hepatitis C recurrence

A recent study by doctors from the Hospital Cl-nic in Barcelona, Spain determined that repeated liver stiffness measurements (LSM) in the first year following liver transplant (LT) could discriminate between slow and rapid "fibrosers" (patients with fibrosis stage of F2-F4 one year post LT).

6 Jan 2010

Research suggests latent cytomegalovirus infection exacerbates inflammatory bowel disease

Current research suggests that latent cytomegalovirus (CMV) infection may exacerbate inflammatory bowel disease (IBD). The related report by Onyeagocha et al, "Latent cytomegalovirus infection exacerbates experimental colitis," appears in the November 2009 issue of The American Journal of Pathology.

21 Oct 2009

Experimental vaccine shows promise in preventing cytomegalovirus infection

Each year, approximately 8,000 infants in the United States develop severe hearing, mental or movement impairments after becoming infected with cytomegalovirus (CMV), a common virus passed onto them while still in the womb.

19 Mar 2009

Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism

A new study conducted by researchers from the University of Verona and the Institute G. Gaslini in Genova, Italy, confirms the pivotal role played by Cytomegalovirus infection in the pathogenesis of atherosclerosis.

1 Jun 2007

Key role played by Cytomegalovirus infection in the pathogenesis of atherosclerosis

30 May 2007

FDA grants fast track status for ViroPharma's Maribavir

ViroPharma Incorporated has announced that the U.S. Food and Drug Administration (FDA) has granted fast track designation for maribavir, an oral antiviral drug candidate for the prevention of cytomegalovirus (CMV) infection in allogeneic bone marrow (stem cell) and solid organ transplant patients.

7 Feb 2006

Cytomegalovirus Infection News and Research

Stem cells give insight into path of cytomegalovirus infection

Vanderbilt researchers receives new $2.1M grant to develop microbrain bioreactor

Hepatitis C virus (HCV)-associated liver disease after liver transplantation

PCR-based saliva test can accurately identify cytomegalovirus infection in newborns

Chimerix’s lipid-conjugated drugs reduces nephrotoxicity: Study

Chimerix to present CMX001 data for viral infections at IDSA Annual Meeting

VBDS secondary to nevirapine use in HIV-positive, pregnant female: Report

Universal screening test for CMV infection is not effective, says study

Life-saving therapeutic interventions possible with early detection of hepatitis C recurrence

Research suggests latent cytomegalovirus infection exacerbates inflammatory bowel disease

Experimental vaccine shows promise in preventing cytomegalovirus infection

Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism

Key role played by Cytomegalovirus infection in the pathogenesis of atherosclerosis

FDA grants fast track status for ViroPharma's Maribavir

Potential cure for lymphoma in HIV patients

Drug to fight virus from the herpes family in transplant patients moves forward in trials

Treatment of cytomegalovirus remains a priority in order to improve the prognosis for people with HIV-1 infection

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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