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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Scientists discover nanoparticle to deliver DNA with minimum toxic effect

In lab experiments, the researchers have found that this device, a vector, is able to deliver DNA deeply enough into a cell to allow genetic material to be activated - a critical step in gene therapy. This vector is between 2 - and 10 times more effective than other experimental materials, according to the research.

7 Jul 2010

Cornerstone reacquires all development, commercial rights to HMGB1 related technology from MedImmune

Cornerstone Therapeutics Inc., a specialty pharmaceutical company focused on acquiring, developing and commercializing significant products primarily for the respiratory and related markets, today announced that the Company has reacquired all development and commercial rights to its high-mobility group box protein 1 (HMGB1) related technology from MedImmune, LLC.

6 Jul 2010

Preclinical efficacy data of Sangamo's ZFN based human stem cell therapy for HIV published

Sangamo BioSciences, Inc. announced the publication of data demonstrating the preclinical efficacy of a human stem cell therapy for human immunodeficiency virus (HIV) based on its proprietary zinc finger DNA-binding protein nuclease (ZFN) technology.

6 Jul 2010

Adeona completes $1 million equity financing and provides update on Zinthionein ZC clinical study

Adeona Pharmaceuticals, Inc., announced today that on July 6, 2010, it completed an equity financing of $1 million with a single institutional investor, Seaside 88, L.P. The financing involved the sale of 1,212,121 registered shares of common stock and no warrants. Enclave Capital served as placement agent and will receive a 7% cash commission and 5-year warrants to acquire 60,606 shares of Adeona at $1.32 per share. The use of proceeds is intended for general corporate purposes.

6 Jul 2010

$CTI submits expanded PIP to EMEA for pixantrone MAA for relapsed or refractory, aggressive NHL$

CTI submits expanded PIP to EMEA for pixantrone MAA for relapsed or refractory, aggressive NHL

Cell Therapeutics, Inc. announced today that it has submitted an expanded Pediatric Investigation Plan to the European Medicines Agency, as part of the process for its submission for a Marketing Authorization Application for pixantrone in the E.U. for the treatment of relapsed or refractory, aggressive non-Hodgkin's lymphoma (NHL).

6 Jul 2010

Novel therapy slows tumor growth in 85% of advanced breast cancer patients: Study

A novel therapy designed to attack tumors in patients with a genetic mutation in either BRCA1 or BRCA2, slowed tumor growth in 85 percent of advanced breast cancer patients treated in a small study, researchers report in the July 6 issue of The Lancet.

6 Jul 2010

Mount Sinai Hospital researchers discover new insights into genesis of stem cells

Mount Sinai Hospital researchers including Drs. Andras Nagy and Jeff Wrana have discovered new insights into the genesis of stem cells, which will improve the efficiency of stem cell creation for use in tissue regeneration and in the development of new drugs.

3 Jul 2010

GeoVax releases two articles on Historic HIV Vaccine Trial

GeoVax Labs, Inc., a biotechnology company that creates, develops and tests innovative HIV/AIDS vaccines, is mentioned in two recent articles covering a historic HIV vaccine trial currently being conducted by the AIDS Research Consortium of Atlanta using a vaccine supplied by GeoVax.

3 Jul 2010

People with high levels of vitamin B6 and methionine less likiely to develop lung cancer

People with higher blood levels of vitamin B6 and the amino acid methionine appear to have a lower risk of lung cancer, a French study has found. But more research is needed to understand if higher levels of the nutrients directly protect against the disease.

3 Jul 2010

Twelve type 2 diabetes susceptibility loci identified

An international team co-led by scientists from the University of Michigan have discovered 12 more regions on the genome with DNA variants that are associated with increased risk of type 2 diabetes, bringing the number to 38.

2 Jul 2010

IBM, University of Missouri collaborate to develop cloud computing environment for genomics research

IBM and the University of Missouri today announced a life sciences research initiative using IBM high performance computing technologies to advance the school's bioinformatics research projects. The goal of the initiative is to develop a first-of-a-kind cloud computing environment for genomics research collaboration at a regional level.

2 Jul 2010

Histone H1 phosphorylation involved in control of ribosomal RNA gene transcription

A protein that helps pack DNA into the cell nucleus has an important role in regulating gene activity, scientists report. The researchers found that the protein, histone H1, also takes part in the formation of ribosomes, the cellular workbenches on which all proteins are made.

2 Jul 2010

Plant extract effective against ulcerative colitis in mice

A South Dakota State University scientist's research shows an extract made from a food plant in the Brassica family was effective in alleviating signs of ulcerative colitis, an inflammatory bowel condition, in mice.

2 Jul 2010

Genentech's second Phase III ICON7 study of Avastin in ovarian cancer meets primary endpoint

Genentech, a member of the Roche Group, announced today that a second large, Phase III, international study showed that the combination of Avastin® (bevacizumab) and chemotherapy, followed by the continued use of Avastin alone, increased the time women with previously untreated ovarian cancer lived without the disease worsening (progression-free survival or PFS, the primary endpoint), compared to chemotherapy alone.

2 Jul 2010

Frozen blood samples shows promise to study mechanism of blood disorders

Cells from frozen human blood samples can be reprogrammed to an embryonic-stem-cell-like state, according to Whitehead Institute researchers. These cells can be multiplied and used to study the genetic and molecular mechanisms of blood disorders and other diseases.

2 Jul 2010

DNA damage caused by UVA radiation leads to melanoma

A new study by researchers at NYU School of Medicine found that UVA radiation damages the DNA in human melanocyte cells, causing mutations that can lead to melanoma. Melanocytes, which contain a substance called melanin that darkens the skin to protect it from the ultraviolet rays of the sun, are more vulnerable to UVA radiation than normal skin cells because they are unable to repair themselves as efficiently.

2 Jul 2010

Researchers identify gene abnormality for most common congenital birth defect, clubfoot

Although clubfoot is one of the most common congenital birth defects, few genetic causes have been found. Now, researchers at Washington University School of Medicine in St. Louis have found what they believe to be the most common cause of inherited clubfoot yet discovered.

2 Jul 2010

Adding nutrients could improve efficiency of deep sea biological pump

Adding nutrients to the sea could decrease viral infection rates among phytoplankton and enhance the efficiency of the biological pump, a means by which carbon is transferred from the atmosphere to the deep ocean, according to a new mathematical modelling study. The findings, published in the Journal of Theoretical Biology, have implications for ocean geo-engineering schemes proposed for tackling global warming.

2 Jul 2010

Genes can predict longevity with 77% accuracy: Study

In an analysis of genes of more than 1,000 centenarians, American researchers have come to the conclusion that genes play a large role in completing a century in life. The research team studied 1,055 Caucasians born between 1890 and 1910 and compared them with 1,267 people born later. They claim that there are signatures in the genetic makeup of these people that have a possible link with their longevity.

2 Jul 2010

Advanced Analytical opens new sales office, lab in Technologiepark at Heidelberg University

Advanced Analytical, headquartered in Ames, IA, has opened a new sales office and laboratory in Heidelberg Germany. The new facility is located in the Technologiepark on the campus of the Heidelberg University. By opening this office, the company will be able to provide better representation over sales for our suite of products sold as well as provide better support and service for our current and future customer base.

2 Jul 2010

DNA News and Research

Further Reading

Scientists discover nanoparticle to deliver DNA with minimum toxic effect

Cornerstone reacquires all development, commercial rights to HMGB1 related technology from MedImmune

Preclinical efficacy data of Sangamo's ZFN based human stem cell therapy for HIV published

Adeona completes $1 million equity financing and provides update on Zinthionein ZC clinical study

CTI submits expanded PIP to EMEA for pixantrone MAA for relapsed or refractory, aggressive NHL

Novel therapy slows tumor growth in 85% of advanced breast cancer patients: Study

Mount Sinai Hospital researchers discover new insights into genesis of stem cells

GeoVax releases two articles on Historic HIV Vaccine Trial

People with high levels of vitamin B6 and methionine less likiely to develop lung cancer

Twelve type 2 diabetes susceptibility loci identified

IBM, University of Missouri collaborate to develop cloud computing environment for genomics research

Histone H1 phosphorylation involved in control of ribosomal RNA gene transcription

Plant extract effective against ulcerative colitis in mice

Genentech's second Phase III ICON7 study of Avastin in ovarian cancer meets primary endpoint

Frozen blood samples shows promise to study mechanism of blood disorders

DNA damage caused by UVA radiation leads to melanoma

Researchers identify gene abnormality for most common congenital birth defect, clubfoot

Adding nutrients could improve efficiency of deep sea biological pump

Genes can predict longevity with 77% accuracy: Study

Advanced Analytical opens new sales office, lab in Technologiepark at Heidelberg University

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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