DNA Damage News and Research

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Major anti-cancer protein released by neutrophils selectively kills tumor cells

A study published in the June 10, 2021 issue of Cell describes a remarkable new mechanism by which the body's own immune system can eliminate cancer cells without damaging host cells.

10 Jun 2021

Researchers clarify cellular processes related to radiation resistance of pancreatic cancer cells

Pancreatic cancer is one of the deadliest cancer subtypes not just because it is difficult to diagnose early, but because it is inherently resistant to chemotherapy and radiotherapy.

8 Jun 2021

Synthetic microRNA can serve as a novel therapeutic agent for treating human cancer

Oncotarget published "Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology" which reported that the authors comprehensively investigated miRNA-193a-3p's mode of action in a panel of human cancer cell lines, with a variety of genetic backgrounds, using 1B3, a synthetic microRNA mimic

2 Jun 2021

Methylene Blue could replace current sunscreen components to protect human skin and the environment

New research using a sunscreen based on Methylene Blue has proven effective in protecting from UV irradiation as well as being safe for coral reefs.

28 May 2021

Study may lead to new treatments that eliminate cancer cells without harming other body cells

Normal cells usually have multiple solutions for fixing problems. For example, when DNA becomes damaged, healthy white blood cells can use several different strategies to make repairs.

28 May 2021

New biomarker could be used to determine resistance of ovarian cancer to platinum chemotherapy

Epithelial ovarian cancer (EOC) is the most common lethal gynaecological cancer. Ovarian cancer is usually treated with platinum-based chemotherapy; however, a significant number of patients are resistant to such treatments and relapse soon afterwards.

28 May 2021

New method to efficiently deliver drugs into cells

A new, patented method called Progressive Mechanoporation makes it possible to mechanically disrupt the membranes of cells for a short time period and let drugs or genes inside cells.

12 May 2021

Targeted therapies could exploit unique metabolic features of pancreatic cancer cells

Probing the unique biology of human pancreatic cancer cells in a laboratory has yielded unexpected insights of a weakness that can be used against the cells to kill them.

7 May 2021

Four-part small-molecule cocktail can prevent cellular stress

Researchers at the National Institutes of Health (NIH) have devised a four-part small-molecule cocktail that can protect stem cells called induced pluripotent stem cells (iPSCs) from stress and maintain normal stem cell structure and function.

4 May 2021

Low doses of ionizing radiation may be a promising therapy for people with Alzheimer’s disease

Individuals living with severe Alzheimer's disease showed remarkable improvements in behavior and cognition within days of receiving an innovative new treatment that delivered low doses of radiation, a recent Baycrest-Sunnybrook pilot study found.

3 May 2021

Researchers investigate how oxygen radicals protect against cancer

Originally, oxygen radicals - reactive oxygen species, or ROS for short - were considered to be exclusively harmful in the body.

26 Apr 2021

Experts to present latest research on aging and longevity at the 8th Aging Research & Drug Discovery Meeting

Scheibye-Knudsen Lab, University of Copenhagen and Deep Longevity are excited to reveal the speakers for the 8th Aging Research & Drug Discovery Meeting, the largest scientific academic, and industry conference that will transpire on August 31 - September 3, 2021, on-site at the Ceremonial Hall, University of Copenhagen, and online.

22 Apr 2021

Rare compound found in a shrub could help fight previously 'undruggable' cancer protein

A chemist from Purdue University has found a way to synthesize a compound to fight a previously "undruggable" cancer protein with benefits across a myriad of cancer types.

20 Apr 2021

Targeted therapy may be of great benefit in early stage breast cancer

Targeted therapy in early stages of breast cancer can pave the way for a notable higher success rate, shows a study from the University of Bergen, Norway.

20 Apr 2021

POT1 gene linked to glioma development mediates its effects in a sex-specific manner

Researchers at Baylor College of Medicine and collaborators at other institutions have discovered that POT1, a gene known to be associated with risk of glioma, the most common type of malignant brain tumor, mediates its effects in a sex-specific manner.

20 Apr 2021

Study uncovers role for STING in regulating tumor response to DNA-damaging treatments

In a study by Yale Cancer Center, researchers report on the discovery of a new role for STimulator of INterferon Genes or STING.

19 Apr 2021

USP7 inhibitors could increase the anticancer effects of CDK1 compounds in cancer patients

Understanding the components that control cell division is fundamental to understanding how life works and how alterations in this delicate process can cause diseases such as cancer.

19 Apr 2021

Novel CRISPR-based technology may lead to powerful epigenetic therapies

Scientists have figured out how to modify CRISPR's basic architecture to extend its reach beyond the genome and into what's known as the epigenome -- proteins and small molecules that latch onto DNA and control when and where genes are switched on or off.

17 Apr 2021

Study shows how proteins work in concert to resolve DNA double-strand breaks

From cancer treatment to sunlight, radiation and toxins can severely damage DNA in both harmful and healthy cells. While the body has evolved to efficiently treat and restore damaged cells, the mechanisms that allow this natural repair remain misunderstood.

16 Apr 2021

Cocoa consumption improves health of obese mice with liver disease

Supplementation of cocoa powder in the diet of high-fat-fed mice with liver disease markedly reduced the severity of their condition, according to a new study by Penn State researchers, who suggest the results have implications for people.

15 Apr 2021

DNA Damage News and Research

Major anti-cancer protein released by neutrophils selectively kills tumor cells

Researchers clarify cellular processes related to radiation resistance of pancreatic cancer cells

Synthetic microRNA can serve as a novel therapeutic agent for treating human cancer

Methylene Blue could replace current sunscreen components to protect human skin and the environment

Study may lead to new treatments that eliminate cancer cells without harming other body cells

New biomarker could be used to determine resistance of ovarian cancer to platinum chemotherapy

New method to efficiently deliver drugs into cells

Targeted therapies could exploit unique metabolic features of pancreatic cancer cells

Four-part small-molecule cocktail can prevent cellular stress

Low doses of ionizing radiation may be a promising therapy for people with Alzheimer’s disease

Researchers investigate how oxygen radicals protect against cancer

Experts to present latest research on aging and longevity at the 8th Aging Research & Drug Discovery Meeting

Rare compound found in a shrub could help fight previously 'undruggable' cancer protein

Targeted therapy may be of great benefit in early stage breast cancer

POT1 gene linked to glioma development mediates its effects in a sex-specific manner

Study uncovers role for STING in regulating tumor response to DNA-damaging treatments

USP7 inhibitors could increase the anticancer effects of CDK1 compounds in cancer patients

Novel CRISPR-based technology may lead to powerful epigenetic therapies

Study shows how proteins work in concert to resolve DNA double-strand breaks

Cocoa consumption improves health of obese mice with liver disease

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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