DNA Methylation News and Research

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DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the most well characterized epigenetic mechanism.

Obesity linked to prostate cancer risk: New study uncovers inherited dangers from fathers

Obesity contributes to prostate cancer risk and can be inherited from obese fathers, as shown in a review of over 280 studies examining obesity's impact on carcinogenesis and heritability.

23 Nov 2023

New study links DNA methylation in GLP1R gene to obesity without metabolic disorders

The study investigates the role of epigenetic changes in GLP1R gene polymorphisms on metabolically healthy obesity (MHO), revealing that apart from genetic variations, DNA methylation significantly influences the occurrence of MHO.

20 Nov 2023

Research opens the door to a potential treatment strategy for certain advanced prostate cancers

Epigenetic changes can cause prostate cancer to resist treatment by switching genes on or off. One epigenetic mechanism tags genes with DNA methylation marks.

15 Nov 2023

Alcohol consumption linked to accelerated biological aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 20, entitled, "Alcohol consumption and epigenetic age acceleration across human adulthood."

14 Nov 2023

Cannabis use alters DNA methylation, with implications beyond smoking effects

A large-scale meta-analysis in Molecular Psychiatry reveals that lifetime cannabis use is associated with DNA methylation changes in peripheral blood, which could have implications for understanding the long-term health effects of cannabis consumption.

8 Nov 2023

The association between neighborhood deprivation, DNA methylation, and gene expression in breast tissue for Black and White women with breast cancer

Researchers investigated the association between neighborhood deprivation and alterations in DNA methylation and gene expression in breast cancer tissues of Black and White women.

7 Nov 2023

Study finds epigenetic signature for obesity susceptibility in human twins

A susceptibility to gain weight may be written into molecular processes of human cells, a Washington State University study indicates.

1 Nov 2023

Study uncovers interplay of lifestyle choices and DNA methylation in gastric neoplasia risk

A new paper in The Lancet eBioMedicine explores whether these changes predict the future risk of stomach tumors and how epigenetic changes interact with environmental and lifestyle factors in this process.

30 Oct 2023

Collaborative team receives NCI grant to study how to improve immunotherapy for diffuse midline gliomas

Each year, approximately 200 to 300 children in the United States are diagnosed with diffuse midline gliomas (DMG), a tumor that begins in the brain or spinal cord.

19 Oct 2023

Kidney transplantation turns back the clock on renal aging

This recent study in the Journal of Internal Medicine reveals that kidney transplantation mitigates the effects of renal aging in chronic kidney disease patients, outperforming dialysis. The research utilized DNA methylation clocks to assess biological age, finding that age acceleration decreased one year post-transplant but remained unchanged with dialysis.

17 Oct 2023

AI-based method shows promise for precision medicine

Artificial intelligence, AI, which finds patterns in complex biological data could eventually contribute to the development of individually tailored healthcare.

12 Oct 2023

New AI model can identify neuroanatomical regions vulnerable to age-related changes

The aging brain undergoes structural and cellular changes that can impact function and increase susceptibility to neurodegenerative disorders like Alzheimer's disease.

11 Oct 2023

New blood test could detect ovarian cancer early, improve treatment

High-grade serous ovarian carcinoma (HGSOC) is the most common type of ovarian cancer. It is also the most lethal form, in part because clinicians do not have effective ways to screen women for it during the cancer's early stages, when it's easiest to treat.

10 Oct 2023

Does renting accelerate biological aging? New study sparks housing policy debate

Living in privately rented homes is linked to faster biological aging, with its impact nearly double that of unemployment. However, these effects are reversible, highlighting the potential of housing policies in health improvement.

10 Oct 2023

Coffee, fiber, and the Mediterranean diet are key players in fighting nonalcoholic fatty liver disease

Dietary patterns, foods, and nutrients to ameliorate nonalcoholic fatty liver disease (NAFLD).

19 Sep 2023

Can your baby's gut bacteria predict food allergies?

Researchers in Italy delve into how changes in gut microbiota during the first 1000 days of life can influence the onset of food allergies in children. The study sheds light on various factors such as birth methods, breastfeeding, and antibiotic use that impact gut health, highlighting the need for more research on effective interventions for allergy prevention.

18 Sep 2023

Can yoga alleviate rheumatoid arthritis severity?

A recent Scientific Reports study investigated the effect of yoga on rheumatoid arthritis (RA) severity.

13 Sep 2023

Is DNA methylation the missing link in diagnosing and treating psoriasis and psoriatic arthritis?

Researchers across Europe have delved into the DNA methylation patterns in CD4+ T-cells of psoriasis and psoriatic arthritis (PsA) patients, unveiling potential new biomarkers for these conditions. Their study suggests that these unique profiles could serve as both diagnostic and prognostic tools, although further validation is needed for real-world clinical application.

10 Sep 2023

Promising new cervical cancer test fills in the gap missed by Pap tests

Researchers assessed a novel human papillomavirus (HPV) and host deoxyribonucleic acid (DNA) methylation score for adenocarcinoma in-situ (AIS) and cervical adenocarcinoma (ADC) screening.

8 Sep 2023

Novel test could improve detection of cervical adenocarcinoma

In findings with potentially important implications for cervical cancer screening, scientists at the National Cancer Institute (NCI)-designated Montefiore Einstein Cancer Center (MECC) have developed a test for detecting a type of cervical cancer that Pap tests often miss.

7 Sep 2023