DNA Sequencing News and Research

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Gene involved in B-cell development might play a role in multiple sclerosis

The results of a large study published today in the open access journal BMC Neurology reveal that multiple sclerosis (MS) patients are more likely to carry two specific genetic variations in the Early B-cell factor gene (EBF-1), than healthy individuals.

30 Oct 2005

First gene mutation associated with Tourette syndrome

Researchers have identified the first gene mutation associated with Tourette syndrome - opening a new avenue for understanding the complex disorder that causes muscle and vocal tics.

13 Oct 2005

SLITRK1 gene appears to contribute to some cases of Tourette's Syndrome

In what may be a major milestone in Tourette's Syndrome (TS) research, scientists at Yale School of Medicine and their colleagues have identified a gene called SLITRK1 that appears to contribute to some cases of TS, according to a report in the October 14 issue of Science.

13 Oct 2005

Sleletal muscle findings highlight the importance of exercise in obese people

The findings suggest that muscle bears a metabolic memory of obesity, which may help to explain why sustained weight loss can be difficult despite cutting calories, according to the researchers. Exercise might more successfully override the aberrant metabolic program in muscle, they suggest, thereby improving the long-term prognosis of those prone to obesity.

11 Oct 2005

Technique for inserting genes into specific sites on the genome in liver cells

The genes are inserted into non-coding regions of the genome so there is no danger of interfering with the functioning of other genes. Once inserted, the gene remains a permanent part of the cell's genome.

10 Oct 2005

Mutations in receptor tyrosine kinases provide potential for highly-targeted cancer therapies

Scientists from J. Craig Venter Institute, Ludwig Institute for Cancer Research, and The Johns Hopkins University School of Medicine identified three novel mutations in two receptor tyrosine kinases in glioblastoma tumors using high throughput sequencing.

26 Sep 2005

Multiple rare mutations within a single gene may increase risk for autism

While debate still rages over the 'cause' of autism, mounting evidence suggests that genetic factors play a major role in the disease.

25 Jul 2005

Discovery of a receptor that appears to function as one "lock" that HSV opens to allow it to enter human cells

It's one of the most common viruses in America, and one that causes the most guilt and shame. It can get inside almost any kind of human cell, reproduce in vast numbers, and linger for years in the body, causing everything from recurrent genital blisters to sores around the mouth. Its complications can kill, and it may increase susceptibility to many nerve and brain disorders.

24 Jul 2005

Hidden secrets on the nature and timing of genome evolution in mammals revealed

Breakages in chromosomes in mammalian evolution have occurred at preferred rather than random sites as long thought, and many of the sites are involved in human cancers, an international team of 25 scientists has discovered.

21 Jul 2005

Rapid new technique for detecting group A streptococcus

Cornell University scientists have developed a rapid, less costly and sensitive new technique for detecting group A streptococcus, the bacteria that cause scarlet fever. Details will be announced today at the Institute of Food Technologists Annual Meeting and Food Expo in New Orleans.

18 Jul 2005

Identical twins lose some fundamental similarities as they grow older

...a new study reports. They may start to look and act less alike. The changes could leave one twin susceptible to diseases like cancer, while the other twin remains healthy.

11 Jul 2005

A new method for manipulating macromolecules

The technique uses double-stranded DNA to direct the behavior of other molecules. In previous DNA nanotechnology efforts, duplex DNA has been used as a static lattice to construct geometrical objects in three dimensions.

29 Jun 2005

New research raises the possibility that the risk of developing arsenic-related disease is not the same for everybody

Children with a particular variation in the CYT19 gene metabolize arsenic differently than adults with the same genetic variant, according to a new research report. The findings have important implications for the safety of drinking water worldwide and the use of arsenic as a cancer drug.

27 Jun 2005

New techniques use mitochondrial DNA as an early indicator for certain types of cancer

A pilot study at the National Institute of Standards and Technology (NIST), in support of the National Cancer Institute's Early Detection Research Network (EDRN), has validated the measurement accuracy of new techniques that use mitochondrial DNA as an early indicator for certain types of cancer.

16 Jun 2005

Inactive gene may explain higher incidence of prostate cancer in African-Americans compared to Caucasians

Among African-Americans with prostate cancer, a tumor-suppressing gene called GSTP1 is inactivated at a rate 3.5 times higher than among Caucasians, according to a study conducted at the San Francisco VA Medical Center (SFVAMC).

16 Jun 2005

Research challenges the evolutionary paradigm that continuous alterations occur during the course of genome evolution

Researchers report today that regions of the human genome have been hotspots for acquiring duplicated DNA sequences - but only at specific time-points during evolution.

16 Jun 2005

Venom of marine cone snails may provide an improved treatment for neuropathic pain associated with diabetes

A cone snail toxin discovered by Melbourne researchers has proven to have great potential for easing pain and could provide an improved treatment for neuropathic pain associated with diabetes.

12 Jun 2005

Accumulation of genetic changes is not solely determined by natural selection

New data suggest that the accumulation of genetic changes is not solely determined by natural selection. A study by University of Chicago researchers contradicts conventional theory by showing that the percentage of mutations accepted in evolution is also strongly swayed by the speed at which new mutations arrive at a gene: the faster the speed of new mutations, the greater the percentage of those mutations accepted.

9 Jun 2005

New bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity

Scientists at Lawrence Livermore National Laboratory (LLNL) and the Linnaeus Centre for Bioinformatics (LCB) at Uppsala University in Sweden have developed a new bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity.

8 Jun 2005

Role of toxins in inherited disease

A disease you are suffering today could be a result of your great-grandmother being exposed to an environmental toxin during pregnancy.

3 Jun 2005

DNA Sequencing News and Research

Gene involved in B-cell development might play a role in multiple sclerosis

First gene mutation associated with Tourette syndrome

SLITRK1 gene appears to contribute to some cases of Tourette's Syndrome

Sleletal muscle findings highlight the importance of exercise in obese people

Technique for inserting genes into specific sites on the genome in liver cells

Mutations in receptor tyrosine kinases provide potential for highly-targeted cancer therapies

Multiple rare mutations within a single gene may increase risk for autism

Discovery of a receptor that appears to function as one "lock" that HSV opens to allow it to enter human cells

Hidden secrets on the nature and timing of genome evolution in mammals revealed

Rapid new technique for detecting group A streptococcus

Identical twins lose some fundamental similarities as they grow older

A new method for manipulating macromolecules

New research raises the possibility that the risk of developing arsenic-related disease is not the same for everybody

New techniques use mitochondrial DNA as an early indicator for certain types of cancer

Inactive gene may explain higher incidence of prostate cancer in African-Americans compared to Caucasians

Research challenges the evolutionary paradigm that continuous alterations occur during the course of genome evolution

Venom of marine cone snails may provide an improved treatment for neuropathic pain associated with diabetes

Accumulation of genetic changes is not solely determined by natural selection

New bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity

Role of toxins in inherited disease

Sequencing & Genomics: Elevating Science and Healthcare eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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