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New technique enables high-resolution analysis of DNA

Function and form are deeply intertwined in biology. Knowing how organisms grow, adapt and reproduce requires understanding their physical structures. Hence the transformative power of the microscope across the past four centuries of science.

4 Aug 2023

TU Graz researchers gain new insights into a light-activated protein switch

Researchers at TU Graz have gained new insights into the functioning of a protein found in bacteria, whose enzymatic activity is activated by blue light.

3 Aug 2023

A comfortable, wearable ultrasound breast patch for breast screening

In a recent study, researchers developed a comfortable ultrasound breast patch (cUSBr-Patch) for breast screening.

2 Aug 2023

Berkeley Lab and Genentech collaborate to develop new lipid nanoparticles for drug delivery

Many diseases can be successfully treated in the simple environment of a cell culture dish, but to successfully treat real people, the drug agent has to take a journey through the infinitely more complex environment within our bodies and arrive, intact, inside the affected cells.

17 Jul 2023

Scientists investigate a bat virus with pandemic potential

The devastating COVID-19 pandemic occurred when the SARS-CoV-2 virus, native to a species of bats, mutated to infect humans.

10 Jul 2023

Scientists develop breakthrough approach to create artificial allosteric sites in protein complexes

According to a recently published research paper by a team of scientists, a groundbreaking approach has been developed to create artificial allosteric sites (where by binding an effector molecule, activity at the distal active site is regulated) in protein complexes.

6 Jul 2023

Endophytic fungi Penicillium verhagenii: an exploration of its anticancer, antioxidant, antimicrobial, and larvicidal activity

Researchers explored the use of endophytic fungi to fabricate selenium nanoparticles.

6 Jun 2023

New method to study the ultra-fast movements of proteins

Proteins are biological molecules that perform almost all biochemical tasks in all forms of life. In doing so, the tiny structures perform ultra-fast movements.

30 May 2023

$Using 3D-electron diffraction to determine the structure of Levocetirizine dihydrochloride$

Using 3D-electron diffraction to determine the structure of Levocetirizine dihydrochloride

For pharmaceuticals, knowing the chemical composition is not enough-;molecular geometry and crystal structure also play an important role in a drug's activity.

23 May 2023

Study should spur the development of alternative range of anti-TB inhibitors

Tuberculosis (TB) is one of the deadliest infectious diseases worldwide that is spread in the air like the common cold. TB is caused by the bacterium Mycobacterium tuberculosis (Mtb) and was responsible for approximately 1.6 million deaths in 2021.

20 Apr 2023

Study uncovers a novel fold within the SARS-CoV-2 replication co-factor non-structural protein 9

Researchers present the crystal structure of an anti-non-structural protein 9 specific nanobody in complex with the SARS-CoV-2 nsp9.

15 Apr 2023

A possible link between aggregation of SARS-CoV-2 proteins and protein misfolding diseases

A new study in the journal Nature Communications aimed to analyze the aggregation propensity in the proteins of both SARS-CoV-2 and SARS-CoV.

21 Feb 2023

Electrochemical method helps to continuously witness and analyze details of protein folding

Scientists are not yet clear on how the tau protein changes from a benign protein essential for normal function in our brains into the toxic neurofibrillary tangles that are a signature of Alzheimer's and other neurodegenerative diseases.

15 Feb 2023

Microscopy techniques reveal a trail of destruction in bone collagen caused by high energy X-rays

A team of medical researchers at Charité has analyzed damage by focused high energetic X-rays in bone samples from fish and mammals at BESSY II.

22 Dec 2022

Structural analysis of monkeypox virus H1 dual phosphatase as a pan-poxvirus target

In a new study, researchers determined the 1.8-Å resolution crystal structure of the H1 dual specific phosphatase (DSP) of monkeypox virus (MPXV) that is crucial for viral replication, making it an attractive antiviral target.

5 Oct 2022

Structural analysis of monkeypox virus to guide the development of broad antiviral agents

In a new study, researchers explored the crystalline structure of the monkeypox (MPX) virus (MPXV) and the complex of VP39, a 2′-O-RNA methyltransferase (MTase) and sinefungin, a pan-MTase inhibitor.

30 Sep 2022

Researchers delve deeper into the structure of protein receptor crucial for cardiovascular health

5 Aug 2022

$Synchrotron X-ray diffraction can aid in the diagnosis of invisible traumatic brain injuries$

Synchrotron X-ray diffraction can aid in the diagnosis of invisible traumatic brain injuries

Traumatic brain injuries (TBIs) are usually diagnosed with MRI and computed tomography scans, but these techniques often miss more mild damage.

31 Jul 2022

Scientists capture a clear picture of the nuclear pore complex using X-rays

Your body is made of close to 100 trillion cells that keep you healthy and alive. Each cell has billions of parts of its own, all of them working in tandem to keep life's processes moving.

11 Jul 2022

Novel oral nano-in-micro system provides efficient curcumin delivery to alleviate ulcerative colitis

A new study showed that the newly designed oral nano-in-micro hydrogel delivery platform could be efficiently used to deliver curcumin for the treatment of Ulcerative Colitis.

5 Jul 2022