Docetaxel News and Research

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Docetaxel is approved by the Food and Drug Administration (FDA) to be used alone or with other drugs to treat certain types of breast and non-small cell lung cancer (NSCLC). It is also approved to be used with other drugs to treat squamous cell carcinoma of the head and neck (SCCHN) and certain types of gastric and prostate cancer.

Docetaxel is a semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent.
First patient enrolled in phase III study of Bevacizumab and Trastuzumab in early breast cancer

First patient enrolled in phase III study of Bevacizumab and Trastuzumab in early breast cancer

Spectrum Pharmaceuticals to present data on Ortataxel in breast cancer at major oncology meeting

Spectrum Pharmaceuticals to present data on Ortataxel in breast cancer at major oncology meeting

Discovery of protein that helps predict prostate cancer survival

Discovery of protein that helps predict prostate cancer survival

Herceptin and chemotherapy improves response rates without major adverse effects in HER2 breast cancer

Herceptin and chemotherapy improves response rates without major adverse effects in HER2 breast cancer

New type of drug shrinks primary breast cancer tumours significantly in just six weeks

New type of drug shrinks primary breast cancer tumours significantly in just six weeks

AstraZeneca completes enrollment in phase III studies of cancer drug vandetanib

AstraZeneca completes enrollment in phase III studies of cancer drug vandetanib

Protein that stimulates blood vessel growth worsens ovarian cancer

Protein that stimulates blood vessel growth worsens ovarian cancer

OHSU Cancer Institute research gives hope for chemo holidays for men with advanced prostate cancer

OHSU Cancer Institute research gives hope for chemo holidays for men with advanced prostate cancer

Avastin cancer drug does well in breast cancer study

Avastin cancer drug does well in breast cancer study

Docetaxel given after doxorubicin reduces recurrence

Docetaxel given after doxorubicin reduces recurrence

Explanation on resistance to taxane class of drugs

Explanation on resistance to taxane class of drugs

FDA approves approved Ixempra (ixabepilone) for advanced breast cancer

FDA approves approved Ixempra (ixabepilone) for advanced breast cancer

Taxol-type drugs give slight boost to survival rates in early breast cancer

Taxol-type drugs give slight boost to survival rates in early breast cancer

Taxotere (docetaxel) granted FDA approval to treat locally advanced head and neck cancer prior to chemo and surgery

Taxotere (docetaxel) granted FDA approval to treat locally advanced head and neck cancer prior to chemo and surgery

Genomic profiling of lung tumors helps doctors choose most effective treatment

Genomic profiling of lung tumors helps doctors choose most effective treatment

Survival data presented from phase II study of hormone-resistant prostate cancer patients

Survival data presented from phase II study of hormone-resistant prostate cancer patients

New AstraZeneca compound shows promoise for hormone resistant prostate cancer patients with bone metastases

New AstraZeneca compound shows promoise for hormone resistant prostate cancer patients with bone metastases

PET scans accurately detect a breast tumor's response to chemotherapy

PET scans accurately detect a breast tumor's response to chemotherapy

BRCA1 gene plays significant role in non-small cell lung cancer

BRCA1 gene plays significant role in non-small cell lung cancer

Some cancer cells mimic stem cells to evade chemotherapy

Some cancer cells mimic stem cells to evade chemotherapy

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