Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

STAT3 protein's ability to cause malignancy is suppressed when neutralized by S31-1757

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have developed a small molecule that inhibits STAT3, a protein that causes cancer.

26 Mar 2013

Gladstone investigator to receive Essey Award for fight against amyotrophic lateral sclerosis

Shinya Yamanaka, MD, PhD, a senior investigator at the Gladstone Institutes, next month will receive the Essey Award for his "Commitment to a Cure" from The ALS Association Golden West Chapter.

26 Mar 2013

Two researchers awarded grants to develop indicators, biomarkers for dementia with Lewy bodies

The Lewy Body Dementia Association and the Alzheimer's Drug Discovery Foundation have awarded $100,000 each to Omar El-Agnaf, PhD, of United Arab Amirates University and Michelle Mielke, PhD, of Mayo Clinic Rochester to provide one year of support for their research projects focused on developing indicators, or biomarkers, for dementia with Lewy bodies.

26 Mar 2013

Calibr, JDRF partner to research on promising type 1 diabetes therapeutic targets

The California Institute for Biomedical Research and JDRF announced a partnership today to apply Calibr's drug discovery expertise to type 1 diabetes research projects in collaboration with academic investigators from JDRF's network.

25 Mar 2013

Scientists identify a new way to develop potential drugs for TB

Scientists have developed a way to pinpoint promising drugs to fight tuberculosis (TB) and other diseases without setting foot in the laboratory.

24 Mar 2013

Synthesis & Solid State Pharmaceutical Centre: an interview with Dr Mary Shire, University of Limerick

This is a new research centre led by the University of Limerick that supports the pharmaceutical sector in Ireland. The centre will carry out research on the key aspects of what it takes to synthesise the pharmaceutically active molecule to isolate a pure material and to formulate this into a medicine.

14 Mar 2013

Scripps Research, Takeda Pharmaceutical to search for new drug targets for different diseases

The Scripps Research Institute and the Takeda Pharmaceutical Company have announced plans to expand their recent research collaboration to search for new drug targets for a variety of diseases.

14 Mar 2013

Sanford-Burnham, Mayo Clinic partner to expand and speed development of new drugs

To expand and speed the development of new drugs for its patients, Mayo Clinic has entered a formal collaboration with Sanford-Burnham Medical Research Institute. Under the agreement, Mayo's discoveries of potential drug targets will be the basis for the development of new drug screening platforms. This will allow future work that focuses on high-throughput screening and medicinal chemistry at Sanford-Burnham facilities.

12 Mar 2013

Global Blood Therapeutics, Array BioPharma partner for drug discovery research

Array BioPharma Inc. and Global Blood Therapeutics today announced a multi-target drug discovery collaboration agreement to identify small molecule lead compounds targeting chronic blood-based diseases.

6 Mar 2013

Microcystins in drinking water

An interview with Rohan Thakur, discussing the prevalence of microcystins in drinking water, and the use of LC-MS to identify cyanotoxins within water samples.

From Bruker Life Sciences Mass Spectrometry 5 Mar 2013

Two renowned SCCP scientists earn national recognition from Society of Toxicology

Two renowned scientists at the South Carolina College of Pharmacy (SCCP) have garnered national recognition from the Society of Toxicology (SoT), which named them recipients of two of its individual annual awards. It is the first time these awards have gone to individuals from the same College.

27 Feb 2013

IFR, PBL to further develop Dynamic Gastric Model

The Dynamic Gastric Model, developed from years of research at the Institute of Food Research, has taken significant steps towards improving its commercial use by food and drug companies worldwide.

26 Feb 2013

Gladstone’s Senior Investigator honored for pioneering work in stem cell biology

Gladstone Institutes' Senior Investigator Shinya Yamanaka, MD, PhD, is one of 11 medical researchers to win a new, high-profile $3 million award from a group of high-tech sponsors, including the founders of Facebook and Google.

22 Feb 2013

TIR-199 shows promise in fighting renal cancer

Chemists at the University of California, Riverside have developed a compound that holds much promise in the laboratory in fighting renal (kidney) cancer.

20 Feb 2013

Researchers create new ultra-sensitive tool for chemical, DNA and protein analysis

Utilizing optical characteristics first demonstrated by the ancient Romans, researchers at the University of Illinois at Urbana-Champaign have created a novel, ultra-sensitive tool for chemical, DNA, and protein analysis.

16 Feb 2013

Researchers identify new way to influence the vital serotonin signaling system

An interdisciplinary team of researchers from the University of Texas Medical Branch at Galveston and the University of Houston has found a new way to influence the vital serotonin signaling system - possibly leading to more effective medications with fewer side effects.

14 Feb 2013

Antibody therapeutics targeting GPCRs to be developed by alliance between MorphoSys and Heptares

MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX) and UK-based Heptares Therapeutics, the leading GPCR drug discovery and development company, have signed an agreement to discover novel antibody therapeutics targeting G protein-coupled receptors (GPCRs), which are membrane proteins involved in a broad range of biological processes and diseases.

13 Feb 2013

New centre to boost development of drugs against TB, malaria and African sleeping sickness

A major new centre to boost the development of drugs to tackle the foremost diseases of the developing world is to be created at the University of Dundee.

13 Feb 2013

RNAi effective in treating cancer patients

The new study published in Cancer Discovery, the flagship journal of the American Association of Cancer Research (AACR), involving three Spanish and six American research centres, presents significant results in treating cancer patients with nanoparticles containing ribonucleic acid interference (RNAi) molecules.

13 Feb 2013

GSK, Vanderbilt partner to develop and commercialize new therapies for severe obesity

Vanderbilt University announced today that it has signed a collaboration agreement with GlaxoSmithKline (GSK) for the discovery, development and commercialization of novel therapies for severe obesity.

13 Feb 2013

Drug Discovery News and Research

Further Reading

STAT3 protein's ability to cause malignancy is suppressed when neutralized by S31-1757

Gladstone investigator to receive Essey Award for fight against amyotrophic lateral sclerosis

Two researchers awarded grants to develop indicators, biomarkers for dementia with Lewy bodies

Calibr, JDRF partner to research on promising type 1 diabetes therapeutic targets

Scientists identify a new way to develop potential drugs for TB

Synthesis & Solid State Pharmaceutical Centre: an interview with Dr Mary Shire, University of Limerick

Scripps Research, Takeda Pharmaceutical to search for new drug targets for different diseases

Sanford-Burnham, Mayo Clinic partner to expand and speed development of new drugs

Global Blood Therapeutics, Array BioPharma partner for drug discovery research

Microcystins in drinking water

Two renowned SCCP scientists earn national recognition from Society of Toxicology

IFR, PBL to further develop Dynamic Gastric Model

Gladstone’s Senior Investigator honored for pioneering work in stem cell biology

TIR-199 shows promise in fighting renal cancer

Researchers create new ultra-sensitive tool for chemical, DNA and protein analysis

Researchers identify new way to influence the vital serotonin signaling system

Antibody therapeutics targeting GPCRs to be developed by alliance between MorphoSys and Heptares

New centre to boost development of drugs against TB, malaria and African sleeping sickness

RNAi effective in treating cancer patients

GSK, Vanderbilt partner to develop and commercialize new therapies for severe obesity

Drug Discovery - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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