Dysplasia News and Research

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Dysplasia is a term used in pathology to refer to an abnormality in maturation of cells within a tissue. This generally consists of an expansion of immature cells, with a corresponding decrease in the number and location of mature cells.

Research: 'Pill on a string' could help detect early signs of oesophageal cancer

A 'pill on a string' developed by researchers at the University of Cambridge could help doctors detect oesophageal cancer - cancer of the gullet - at an early stage, helping them overcome the problem of wide variation between biopsies, suggests research published today in the journal Nature Genetics.

21 Jul 2015

Researchers explore how Sox9 protein regulates production of cartilage

Cartilage does a lot more than determine the shapes of people's ears and noses. It also enables people to breathe and to form healthy bones -- two processes essential to life. In a study published in Cell Reports, USC Stem Cell researcher Xinjun He and University of Tokyo researcher Shinsuke Ohba explore how a protein called Sox9 regulates the production of cartilage.

3 Jul 2015

Proscia’s cloud-based platform allows clinicians, hospitals to make faster and more accurate cancer diagnosis

Proscia, a cloud-delivered solutions provider for digital pathology, today announced the release of a series of new features including Proscia Connect.

1 Jul 2015

MSD announces EC approval of SIMPONI (golimumab) for treatment of adult patients with nr-axial SpA

MSD (Merck & Co., Inc., Kenilworth, New Jersey, USA) today announced that on 22 June the European Commission approved SIMPONI (golimumab) for the treatment of adult patients with severe, active non-radiographic axial spondyloarthritis (nr-axial SpA).

26 Jun 2015

Study reveals benefit of early screening for vascular disorder patent ductus arteriosus among preterm infants

Among extremely preterm infants, early screening for the vascular disorder patent ductus arteriosus before day 3 of life was associated with a lower risk of in-hospital death and pulmonary hemorrhage, but not with differences in other severe complications, according to a study in the June 23/30 issue of JAMA.

24 Jun 2015

JAMA: Extremely preterm infants enrolled in randomized clinical trials experience neither better nor worse outcomes

In a group of more than 5,000 extremely preterm infants, important in-hospital outcomes were neither better nor worse in infants enrolled in randomized clinical trials (RCTs) compared with eligible but nonenrolled infants, findings that may provide reassurance regarding concerns about performing RCTs in this vulnerable population, according to a study in the June 16 issue of JAMA.

17 Jun 2015

Simple process for obtaining induced pluripotent stem cells without use of reagents

For their ability to differentiate into other cell types, the embryonic stem cells hold a large potential in the medical industry. Their use, however, poses ethical questions due to the fact that in order to obtain them, it is necessary to destroy the embryo. For this reason, medical researches use the so-called induced pluripotent stem cells (iPSC). In fact, it is possible to reprogram adult cells that can be obtained by simply drawing blood and making them "regress" to a similar state to that of embryonic stem cells.

10 Jun 2015

NGS mutational testing can help detect patients with Barrett's esophagus

Barrett's esophagus (BE) develops in a subset of patients with gastroesophageal reflux disease (GERD) and can increase the risk of developing cancer of the esophagus. Although periodic surveillance for cancer is recommended for BE patients, these examinations may fail to identify pre-cancerous dysplasia and early cancers.

9 Jun 2015

Multi-center study shows WATS3D biopsy increases detection of esophageal pre-cancer by 60% following endoscopic ablation of Barrett’s Esophagus

CDx Diagnostics announced today new clinical data from a multi-center study demonstrating the utility of the WATS3D biopsy for post-ablation surveillance of Barrett’s esophagus and esophageal dysplasia...

18 May 2015

Multi-center study shows WATS3D biopsy increases detection of esophageal pre-cancer by 60% following endoscopic ablation of Barrett’s Esophagus

18 May 2015

Studies support use of ThyraMIR and ThyGenX to improve detection of benign/malignant thyroid nodules

Data will be presented at both Digestive Disease Week (DDW) and the American Association of Clinical Endocrinologists (AACE) annual medical meetings.

18 May 2015

Electroclinical triggers for repeat MRI in intractable epilepsy identified

Researchers have outlined the electroclinical features typically associated with bottom-of-sulcus dysplasia, the surgical removal of which often cures epilepsy in affected patients.

30 Apr 2015

Adult survivors of preterm births at higher risk of developing COPD

Adult survivors of preterm births may have a lung capacity that resembles the healthy elderly or casual smokers by the time they reach their early 20s, according to a University of Oregon study.

30 Apr 2015

New research could transform treatments for patients with Barrett's Oesophagus

New research from the University of Warwick and University Hospitals Coventry and Warwickshire NHS Trust could transform treatments and diagnosis for a common digestive condition which affects thousands of patients.

15 Apr 2015

UAB scientist explores the bone development function of runx2 gene

Amjad Javed, Ph.D., of the University of Alabama at Birmingham, has taken a major step forward in understanding the bone development function of a gene called runx2, which could lead to future ways to speed bone healing, aid bone bioengineering, stem osteoporosis and reduce arthritis.

30 Mar 2015

Women with IBD may be at increased risk for developing cervical cancer

Women with inflammatory bowel disease (IBD) may be at increased risk of cervical dysplasia and cancer, according to a new study1 published in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

27 Mar 2015

New AGA guideline changes clinical practice for patients with asymptomatic pancreatic cysts

A new guideline from the American Gastroenterological Association changes clinical practice by recommending longer surveillance periods for patients with asymptomatic pancreatic cysts and new criteria that limits surgery to those who will receive the most benefit.

25 Mar 2015

Brain-somatic-activating mutations in MTOR cause focal cortical dysplasia type II

Epilepsy is a brain disorder that afflicts more than 50 million people worldwide. Many epilepsy patients can control their symptoms through medication, but about 30% suffer from intractable epilepsy and are unable to manage the disease with drugs. Intractable epilepsy causes multiple seizures, permanent mental, physical, and developmental disabilities, and even death.

25 Mar 2015

Research suggests genetic predisposition to spontaneous coronary artery disease

A Mayo Clinic study has identified a familial association in spontaneous coronary artery dissection, a type of heart attack that most commonly affects younger women, suggesting a genetic predisposition to the condition, researchers say.

24 Mar 2015

CHOPS syndrome sheds light on key biological processes during human development

Analyzing a puzzling multisystem disorder in three children, genetic experts have identified a new syndrome, shedding light on key biological processes during human development. The research also provides important information to help caregivers manage the disorder, and may offer clues to eventually treating it.

3 Mar 2015

Dysplasia News and Research

Research: 'Pill on a string' could help detect early signs of oesophageal cancer

Researchers explore how Sox9 protein regulates production of cartilage

Proscia’s cloud-based platform allows clinicians, hospitals to make faster and more accurate cancer diagnosis

MSD announces EC approval of SIMPONI (golimumab) for treatment of adult patients with nr-axial SpA

Study reveals benefit of early screening for vascular disorder patent ductus arteriosus among preterm infants

JAMA: Extremely preterm infants enrolled in randomized clinical trials experience neither better nor worse outcomes

Simple process for obtaining induced pluripotent stem cells without use of reagents

NGS mutational testing can help detect patients with Barrett's esophagus

Multi-center study shows WATS3D biopsy increases detection of esophageal pre-cancer by 60% following endoscopic ablation of Barrett’s Esophagus

Multi-center study shows WATS3D biopsy increases detection of esophageal pre-cancer by 60% following endoscopic ablation of Barrett’s Esophagus

Studies support use of ThyraMIR and ThyGenX to improve detection of benign/malignant thyroid nodules

Electroclinical triggers for repeat MRI in intractable epilepsy identified

Adult survivors of preterm births at higher risk of developing COPD

New research could transform treatments for patients with Barrett's Oesophagus

UAB scientist explores the bone development function of runx2 gene

Women with IBD may be at increased risk for developing cervical cancer

New AGA guideline changes clinical practice for patients with asymptomatic pancreatic cysts

Brain-somatic-activating mutations in MTOR cause focal cortical dysplasia type II

Research suggests genetic predisposition to spontaneous coronary artery disease

CHOPS syndrome sheds light on key biological processes during human development

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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