Dysplasia News and Research

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Dysplasia is a term used in pathology to refer to an abnormality in maturation of cells within a tissue. This generally consists of an expansion of immature cells, with a corresponding decrease in the number and location of mature cells.

Mount Sinai researchers uncover genetic basis of fibromuscular dysplasia

Mount Sinai researchers have identified a key driver of a blood vessel disorder known as fibromuscular dysplasia (FMD) which affects up to five percent of the adult population and can lead to high blood pressure, heart attack, or stroke.

14 Sep 2024

ANNs can identify lung disease in preterm infants by analyzing sleep breathing patterns

Artificial Neural Networks (ANNs) can be trained to detect lung disease in premature babies by analyzing their breathing patterns while they sleep, according to research presented at the European Respiratory Society (ERS) Congress in Vienna, Austria.

9 Sep 2024

Defective ZNRF3 gene causes opposing brain sizes and potential tumor risk

A gene called ZNRF3, known to be involved in cancer, also messes with the mind. The human brain relies on two copies of this gene to build a right-sized brain. If one of the copies is defective, the brain will be either too small or too large - known as mirror effect -, leading to various neurological symptoms.

23 Aug 2024

Expanding the TTN mutation spectrum for dilated cardiomyopathy diagnosis

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Dilated cardiomyopathy (DCM), a severe heart disease, is the leading cause of heart failure and sudden cardiac death worldwide.

19 Aug 2024

Increased skin-to-skin time linked to better neurodevelopment

Skin-to-skin cuddling with a parent has lasting cognitive benefits for premature babies, according to a new Stanford Medicine study. Preemies who received more skin-to-skin contact, also known as kangaroo care, while hospitalized as newborns were less likely to be developmentally delayed at 1 year of age, the study found.

8 Aug 2024

Novel blood test could predict chronic lung disease in preterm babies within hours of birth

A blood test can help predict which preterm babies will go onto develop chronic lung disease, allowing for earlier diagnosis and more targeted treatments, according to a new study.

7 Aug 2024

New technology reveals the critical role of sleep in infant brain development

Researchers have developed advanced technology to measure neonatal sleep patterns, revealing how sleep significantly impacts brain development before and after birth.

8 Jul 2024

Neanderthal child with Down syndrome reveals ancient caregiving practices

Research reveals that Neanderthals provided extensive caregiving, allowing a child with Down syndrome and congenital ear pathology to survive for at least six years, highlighting their complex social structures.

1 Jul 2024

AGA releases new evidence-based guideline on managing Barrett's esophagus and related neoplasia

The American Gastroenterological Association's (AGA) new evidence-based Clinical Practice Guideline on Endoscopic Eradication Therapy of Barrett's Esophagus and Related Neoplasia, published today in Gastroenterology, establishes updated guidance for Barrett's esophagus patients.

17 May 2024

Heightened risk of adverse neonatal outcomes from prenatal exposure to both cannabis and nicotine

A recent JAMA Network Open study found that combined prenatal use of nicotine and cannabis significantly increases risks for adverse perinatal outcomes, such as higher rates of hypertensive disease, preterm delivery, and elevated infant mortality compared to using neither or only one substance.

9 May 2024

Groundbreaking study unveils sex-specific genetic influences on blood pressure

Genetic heterogeneity of blood pressure (BP) effects between sexes.

12 Mar 2024

Investigational protein replacement protects neonatal mice from deadly intestinal disease

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and colleagues found that an investigational protein replacement – recombinant human insulin-like growth factor 1 and its binding protein-3 (rhIGF-1/BP3) – protected neonatal mice from necrotizing enterocolitis (NEC), a deadly intestinal disease that often strikes extremely premature infants.

28 Feb 2024

New discovery sheds light on the genetic basis of a rare skeletal disorder

A McGill-led team of researchers have made an important discovery shedding light on the genetic basis of a rare skeletal disorder.

19 Jan 2024

UCL researchers develop new gene therapy to cure severe childhood epilepsy

UCL researchers have developed a new gene therapy to cure a devastating form of childhood epilepsy, which a new study shows can significantly reduce seizures in mice.

14 Dec 2023

Study identifies key factor in lung and eye damage in preemies

Advancements in the care of premature babies are leading to improved survival rates. However, the incidence of neonatal diseases with life-long consequences such as bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) is increasing.

11 Dec 2023

Rising colorectal cancer risk in young adults calls for earlier screening, study suggests

Study reveals an increase in adenomas and advanced adenomas in younger adults, alongside a rise in colorectal cancer incidence in males under 50, suggesting a need for earlier screening, particularly in men.

7 Dec 2023

Effects of using race and ethnicity in clinical algorithms in health care systems

A Special Issue of the peer-reviewed journal Health Equity focuses attention on the incorrect use of race and ethnicity in clinical algorithms in health care systems across the U.S. and internationally. The Special Issue is titled "Race Adjustment in Clinical Algorithms and Other Clinical Decision-making Tools."

4 Dec 2023