Dysplasia News and Research

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Dysplasia is a term used in pathology to refer to an abnormality in maturation of cells within a tissue. This generally consists of an expansion of immature cells, with a corresponding decrease in the number and location of mature cells.

C-Path receives grant to collect real-world data for real-world evidence in neonatology

Arizona-based Critical Path Institute is pleased to announce it has been awarded a multi-year grant by the U.S. Food and Drug Administration to advance standards and methodologies designed to generate real-world evidence from real-world data through a neonatal pilot project through the International Neonatal Consortium.

27 Oct 2020

New tool can employ MRI scan data to predict motor development risks for preterm infants

As many as 70% of very premature infants (born earlier than 32 weeks gestation) show signs of white matter abnormalities at birth. But only some of those infants go on to develop cognitive, language, motor, or behavioral disorders as they grow.

30 Sep 2020

Study identifies genetic mutation associated with rare blood vessel disease

Understanding of fibromuscular dysplasia (FMD), a rare blood vessel disease, is making the jump from the laboratory to the clinic with new findings about a genetic variant.

24 Sep 2020

ASCRS releases updated recommendations for surgery in patients with Crohn's disease

Although rates of surgery for Crohn's disease have decreased over the years, many patients still require surgical treatment - due to inadequate responses to medical therapy, severe attacks of acute colitis, and many other situations.

23 Jul 2020

Guidelines for making neutering decision

Some dog breeds have higher risk of developing certain cancers and joint disorders if neutered or spayed within their first year of life. Until now, studies had only assessed that risk in a few breeds.

16 Jul 2020

Airway and Celonic collaborate to produce AT-100 as therapeutic candidate against COVID-19

Airway Therapeutics, Inc., a biopharmaceutical company developing a new class of biologics to break the cycle of injury and inflammation for patients with respiratory and inflammatory diseases, and Celonic Group, a premium biopharmaceutical CDMO specialized in the development and production of Advance Therapy Medicinal Products (ATMPs) and mammalian cell line-expressed biotherapeutics, today announced a collaboration to produce the novel human recombinant protein AT-100 (rhSP-D) as a therapeutic candidate against COVID-19.

21 May 2020

Study: New combination treatment significantly improves degenerative joint diseases

Hutchinson-Gilford Progeria Syndrome (HGPS) is a fatal condition that is especially prevalent in the skin, cardiovascular and the musculoskeletal systems. There exists a wide gap between existing knowledge of the disease and a potential treatment or cure.

12 May 2020

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers.

25 Mar 2020

Validation of a better risk stratification system for bronchopulmonary dysplasia

Factoring in the total number of days that extremely preterm infants require supplemental oxygen and tracking this metric for weeks longer than usual improves clinicians' ability to predict respiratory outcomes according to bronchopulmonary dysplasia severity, a research team led by Children's National Hospital writes in Scientific Reports.

11 Mar 2020

Canine study discovers novel genes associated with hip dysplasia and osteoarthritis

Hip dysplasia, common in both dogs and humans, and associated osteoarthritis are complex disorders influenced by a multitude of genes.

11 Mar 2020

'Stranger Things' increased public awareness of cleidocranial dysplasia

A new study published in February 2020 in the journal JAMA Otolaryngology-Head and Neck Surgery shows that using mainstream media to depict rare diseases in a realistic manner can prompt greater public awareness and support for such conditions.

20 Feb 2020

Researchers compile large catalog of cancer mutations

Mutations in 38 different types of cancer have been mapped by means of whole genome analysis by an international team of researchers from, amongst others, the University of Copenhagen, Aarhus University, Aarhus University Hospital, and Rigshospitalet.

6 Feb 2020

Small birthweight can cause breathlessness in later life, finds study

A new study finds that babies born small for their gestational age are not so fit when it comes to their heart and lungs capacity.

31 Jan 2020

Preterm survival rate up by 25 percent thanks to the quality improvement program

Preterm birth occurs before 37 weeks of gestation and has been tied to many complications in the infant. In Canada, the rate of survival of very preterm infants born between 28 to 32 weeks, improved by 25 percent, thanks to the national Evidence-based Practice for Improving Quality (EPIQ) program in neonatal intensive care units (NICUs) across the country.

27 Jan 2020

Airway Therapeutics receives funding to advance BPD treatment

Airway Therapeutics, Inc., a biopharmaceutical company developing a new class of biologics to break the injury cycle of inflammation for patients with respiratory and inflammatory diseases, announced today the closing of a $15.5 million oversubscribed Series C financing round.

8 Jan 2020

AGA publishes clinical guideline for managing patients with gastric intestinal metaplasia

Gastric intestinal metaplasia (GIM), which is linked to non-cardia gastric cancer, is often detected during routine endoscopy, leading to questions about how patient care should be managed.

10 Dec 2019

Perinatal maternal antibiotic exposure may impair lung development in premature infants

New research in mice suggests that exposure to antibiotics before birth may impair lung development in premature infants. The study, the first to explore the gut-lung axis in prematurity, is published ahead of print in the American Journal of Physiology—Lung Cellular and Molecular Physiology and was chosen as an APSselect article for December.

5 Dec 2019

Researchers study the effects of hyperoxia on the lung development of germ-free newborn mice

Charitharth Vivek Lal, M.D., and University of Alabama at Birmingham colleagues have used a novel and first-of-its-kind newborn mouse model to study the effect of high oxygen concentrations, or hyperoxia, on lung development of newborn mice that are germ-free -- meaning no microbes colonizing their lungs.

21 Nov 2019

Premature babies with bronchopulmonary dysplasia have more stem cells at birth

In the first large-scale clinical study to characterize stem cells from the umbilical cord blood and tissues of premature infants with bronchopulmonary dysplasia – a severe, chronic lung disease – researchers found that these babies had more stem cells at birth.

5 Nov 2019

Study explores how the human lung develops at single cell level

The invention of interactive map applications has revolutionized wayfinding, providing an unprecedented level of information far beyond what printed road maps can offer.

18 Oct 2019