Dysplasia News and Research

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Dysplasia is a term used in pathology to refer to an abnormality in maturation of cells within a tissue. This generally consists of an expansion of immature cells, with a corresponding decrease in the number and location of mature cells.

Nanoparticle-based therapy alleviates pulmonary hypertension in mouse model of rare lung disease

The disease is so rare and complex that its acronym is hard to pronounce. But for infants unlucky enough to be born with this lung disease, the outcome is usually fatal.

14 Jun 2021

Very preterm or very low birthweight children may require special support to boost their learning

The average IQ of adults who were born very preterm (VP) or at a very low birth weight (VLBW) has been compared to adults born full term by researchers from the Department of Psychology at the University of Warwick.

1 Jun 2021

Phase 2 trial shows INO-4800 SARS-CoV-2 DNA vaccine safe and tolerable in adults

Preliminary clinical trial results from an ongoing Phase 2/3 trial led by Laurent M. Humeau of Inovio Pharmaceuticals suggest the two-dose INO-4800 vaccine is safe for use in adults of varying ages. The results expand on phase 1 trial results that found the vaccine was safe and tolerable in 38 participants.

16 May 2021

Research could inform therapeutic approaches to ameliorate the effects of fetal immobility

Researchers from Trinity College Dublin have discovered that some skeletal defects associated with a lack of movement in the womb during early development may still be ameliorated after such periods of immobility if movement resumes.

23 Apr 2021

Study evaluates stem cells' ability to prevent major cause of death in preterm infants

A phase 2 clinical trial whose results were released today in STEM CELLS Translational Medicine might point to a way to overcome bronchopulmonary dysplasia (BPD), a major cause of death in preterm infants.

20 Apr 2021

New technique may result in earlier and easier identification of patients with Barrett's esophagus

A new technique for sampling and testing cells from Barrett's esophagus (BE) patients could result in earlier and easier identification of patients whose disease has progressed toward cancer or whose disease is at high risk of progressing toward cancer, according to a collaborative study by investigators at Case Western Reserve University and Johns Hopkins Kimmel Cancer Center (JHKCC).

23 Mar 2021

Mice study shows gut mycobiome influences the metabolism of processed diet

Studies of the microbiome in the human gut focus mainly on bacteria. Other microbes that are also present in the gut -- viruses, protists, archaea, and fungi -- have been largely overlooked.

8 Mar 2021

New taxonomic classification of non-skeletal rare congenital disorders with impact on bone physiology

Thanks to major progress in the understanding and management of rare congenital diseases and syndromes, many patients with these rare disorders are now living longer lives.

13 Jan 2021

Study: Anal intraepithelial neoplasia is a precursor lesion for anal squamous cell carcinomas

Oncotarget recently published "PD-1/PD-L1 expression in anal squamous intraepithelial lesions" which reported that the presence and distribution of CD8 lymphocytes and the presence of PD-1 lymphocytes and PD-L1 epithelial cells were assessed.

12 Jan 2021

Researchers use massive sequencing methods to identify rare genetic bone disorder

Researchers of the "Cell Biology and Physiology-LABRET" group of the University of Malaga (UMA), together with the Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), have described a new genetic skeletal disorder based on a precision medicine strategy.

22 Dec 2020

Researchers use precision medicine strategy to identify a new genetic skeletal disorder

21 Dec 2020

C-Path receives grant to collect real-world data for real-world evidence in neonatology

Arizona-based Critical Path Institute is pleased to announce it has been awarded a multi-year grant by the U.S. Food and Drug Administration to advance standards and methodologies designed to generate real-world evidence from real-world data through a neonatal pilot project through the International Neonatal Consortium.

27 Oct 2020

New tool can employ MRI scan data to predict motor development risks for preterm infants

As many as 70% of very premature infants (born earlier than 32 weeks gestation) show signs of white matter abnormalities at birth. But only some of those infants go on to develop cognitive, language, motor, or behavioral disorders as they grow.

30 Sep 2020

Study identifies genetic mutation associated with rare blood vessel disease

Understanding of fibromuscular dysplasia (FMD), a rare blood vessel disease, is making the jump from the laboratory to the clinic with new findings about a genetic variant.

24 Sep 2020

ASCRS releases updated recommendations for surgery in patients with Crohn's disease

Although rates of surgery for Crohn's disease have decreased over the years, many patients still require surgical treatment - due to inadequate responses to medical therapy, severe attacks of acute colitis, and many other situations.

23 Jul 2020

Guidelines for making neutering decision

Some dog breeds have higher risk of developing certain cancers and joint disorders if neutered or spayed within their first year of life. Until now, studies had only assessed that risk in a few breeds.

16 Jul 2020

Airway and Celonic collaborate to produce AT-100 as therapeutic candidate against COVID-19

Airway Therapeutics, Inc., a biopharmaceutical company developing a new class of biologics to break the cycle of injury and inflammation for patients with respiratory and inflammatory diseases, and Celonic Group, a premium biopharmaceutical CDMO specialized in the development and production of Advance Therapy Medicinal Products (ATMPs) and mammalian cell line-expressed biotherapeutics, today announced a collaboration to produce the novel human recombinant protein AT-100 (rhSP-D) as a therapeutic candidate against COVID-19.

21 May 2020

Study: New combination treatment significantly improves degenerative joint diseases

Hutchinson-Gilford Progeria Syndrome (HGPS) is a fatal condition that is especially prevalent in the skin, cardiovascular and the musculoskeletal systems. There exists a wide gap between existing knowledge of the disease and a potential treatment or cure.

12 May 2020

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers.

25 Mar 2020

Validation of a better risk stratification system for bronchopulmonary dysplasia

Factoring in the total number of days that extremely preterm infants require supplemental oxygen and tracking this metric for weeks longer than usual improves clinicians' ability to predict respiratory outcomes according to bronchopulmonary dysplasia severity, a research team led by Children's National Hospital writes in Scientific Reports.

11 Mar 2020