Efficacy News and Research

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New vaccine to stop cocaine addiction

Xenova Group plc has announced the presentation of results of two dose escalation Phase II studies of TA-CD, a vaccine being developed for the treatment of cocaine addiction, at the College on Problems of Drug Dependence 66th Annual Scientific Meeting in Puerto Rico, June 12-17.

14 Jun 2004

Cannabis extract drug may help patients with rheumatoid arthritis

The multi centre double blind, randomised, parallel group study in 58 patients assessed the efficacy, safety and tolerability of Sativex®, a whole plant medicinal cannabis extract, compared with placebo for the treatment of pain caused by Rheumatoid Arthritis. Study medication was administered by means of a spray into the mouth as an evening dose only and measures were assessed the following day.

11 Jun 2004

Sirolimus-based therapy following early cyclosporine withdrawal improves transplanted kidney structure and function

Kidney histology and function three years after transplantation are better in kidney-transplant patients who remain on sirolimus-based therapy following early withdrawal of cyclosporine than in patients who continue on this calcineurin inhibitor, according to a new study published in the American Journal of Transplantation.

11 Jun 2004

65 percent of America’s adults are overweight and 31 percent of adults are obese and at risk for chronic diseases

Government and private sector health experts now estimate that 65 percent of America’s adults are overweight and 31 percent of adults are obese and at risk for chronic diseases such as diabetes and hypertension. The link between obesity and hypertension is well known, but the exact nature of the association between the two disorders remains unclear.

11 Jun 2004

WHO welcomes G8 endorsement of the Global HIV Vaccine Enterprise

The World Health Organization (WHO) and the Joint United Nations Programme on HIV/AIDS (UNAIDS) today welcomed the G8's endorsement of the Global HIV Vaccine Enterprise, a virtual consortium proposed by an international group of scientists that is being established to accelerate HIV vaccine development.

11 Jun 2004

Enbrel therapy allowed more rheumatoid arthritis patients to achieve clinical remission

New results from TEMPO (Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes) demonstrated that Enbrel® (etanercept) therapy allowed significantly more rheumatoid arthritis (RA) patients to achieve clinical remission at two years compared to patients treated with methotrexate alone.

11 Jun 2004

New York State accuses GlaxoSmithKline of fraudulent behaviour

This week's editorial calls on GlaxoSmithKline (GSK) to make all its research on paroxetine (Seroxat/Paxil) publicly available. This follows the filing of last week's law suit by the state of New York against GSK: the state accuses the company of fraud

11 Jun 2004

Remicade shows improvement in both the arthritis and psoriasis associated with psoriatic arthritis

In this trial, REMICADE provided a 70 percent improvement (as measured by ACR 70) in symptoms of arthritis in nearly one-third of patients, compared with only 2 percent of patients on placebo at 24 weeks.

10 Jun 2004

Non-aspirin pain drugs may help men with recurrent prostate cancer

Early results from a University of North Carolina at Chapel Hill School of Medicine study may determine if drugs called Cox-2 inhibitors, a newer type of non-aspirin pain medicine now widely prescribed for arthritis symptoms, may benefit men with recurrent prostate cancer.

10 Jun 2004

Discovery could pave the way to smallpox Immunity

A team of scientists led by a Howard Hughes Medical Institute (HHMI) international research scholar has discovered the immune system mechanism that causes some mice to be more susceptible to mousepox than others.

9 Jun 2004

Market research - European Electronic Medical Records

The overwhelming need for cost-effective and high-quality healthcare delivery is motivating the implementation of IT solutions such as the electronic medical records (EMR) system.

9 Jun 2004

Many epilepsy and multiple sclerosis patients believe marijuana is an effective treatment

Despite limited evidence of effectiveness, many epilepsy and multiple sclerosis patients believe marijuana is an effective treatment and are actively using it, according to two Canadian studies published in the June 8 issue of Neurology, the scientific journal of the American Academy of Neurology.

9 Jun 2004

Investigational drug, LAF237 improved glycemic control in patients with type 2 diabetes

Research presented today showed that the investigational drug, LAF237, the first in a new class, improved glycemic control in patients with type 2 diabetes. In this study, LAF237, which is administered as a tablet to be taken orally, was added to the standard diabetes treatment metformin in patients whose diabetes was not adequately controlled by metformin alone.

7 Jun 2004

Velcade major improvement over standard therapy for relapsed multiple myeloma

Early results from a major, international Phase III clinical trial decisively show that recurrent multiple myeloma is more effectively treated with the drug bortezomib (trade name: Velcade TM) than with dexamethasone, a drug that for decades has been the standard therapy for relapsed disease, researchers at Dana-Farber Cancer Institute report.

6 Jun 2004

Antipsychotic compound bifeprunox worth USD 1 billion per year to Solvay and Wyeth

Solvay has re-evaluated the commercial potential of bifeprunox, a Solvay compound in clinical development for the treatment of schizophrenia . Bifeprunox additionally has the potential to be developed in other disorders, i.e. bipolar disorder.

3 Jun 2004

Study may help oncologists tailor chemotherapy to patients based on their genetic make-up

Genetic variations in an individual’s ability to repair DNA damage may help predict survival in lung cancer patients treated with the common chemotherapy drugs cisplatin or carboplatin, a new study shows.

2 Jun 2004

Research laboratory at the forefront of the science of metabolomics

A new $1.8 million research laboratory will catapult Iowa State University to the forefront of the science of metabolomics.

2 Jun 2004

BioSante publishes oral insulin study

BioSante Pharmaceuticals, Inc. has announced the publication of positive results of a preclinical study of its proprietary calcium phosphate nanoparticle (CAP) delivery system for the oral delivery of insulin in the June 11 issue of the peer-reviewed International Journal of Pharmaceutics.

2 Jun 2004

Prescribing ACE inhibitors to in-patients is important, but outpatients need ongoing support

Use of angiotensin-converting enzyme (ACE) inhibitors by heart failure patients drops sharply within a month after they go home from the hospital and then continues to decline, according to a new study in the June 2, 2004 issue of the Journal of the American College of Cardiology.

2 Jun 2004

Where you live may increase risk factors for asthma

Along with the usual risk factors for asthma such as smoking and poverty, researchers have added another factor that may contribute: a neighborhood where people live in fear.

1 Jun 2004

Efficacy News and Research

New vaccine to stop cocaine addiction

Cannabis extract drug may help patients with rheumatoid arthritis

Sirolimus-based therapy following early cyclosporine withdrawal improves transplanted kidney structure and function

65 percent of America’s adults are overweight and 31 percent of adults are obese and at risk for chronic diseases

WHO welcomes G8 endorsement of the Global HIV Vaccine Enterprise

Enbrel therapy allowed more rheumatoid arthritis patients to achieve clinical remission

New York State accuses GlaxoSmithKline of fraudulent behaviour

Remicade shows improvement in both the arthritis and psoriasis associated with psoriatic arthritis

Non-aspirin pain drugs may help men with recurrent prostate cancer

Discovery could pave the way to smallpox Immunity

Market research - European Electronic Medical Records

Many epilepsy and multiple sclerosis patients believe marijuana is an effective treatment

Investigational drug, LAF237 improved glycemic control in patients with type 2 diabetes

Velcade major improvement over standard therapy for relapsed multiple myeloma

Antipsychotic compound bifeprunox worth USD 1 billion per year to Solvay and Wyeth

Study may help oncologists tailor chemotherapy to patients based on their genetic make-up

Research laboratory at the forefront of the science of metabolomics

BioSante publishes oral insulin study

Prescribing ACE inhibitors to in-patients is important, but outpatients need ongoing support

Where you live may increase risk factors for asthma

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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