Efficacy News and Research

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Study finds substantial differences in cancer drug funding decisions across high-income countries

Despite the use of similar assessment criteria when deciding whether new cancer drugs should receive funding, there are substantial differences in drug funding decisions, across comparable high-income countries.

2 Jun 2023

Lupus Therapeutics announces three Phase 3 clinical trials testing new therapies for SLE and lupus nephritis

Lupus Therapeutics announced the start of a collaboration to conduct three Phase 3 clinical trials testing an investigational therapeutic ianalumab for systemic lupus erythematosus and lupus nephritis.

2 Jun 2023

Understanding factors associated with long-term opioid use in fibromyalgia patients

Fibromyalgia is common, affecting around 2% of people in the general population. The 2017 EULAR recommendations state that tramadol - a weak opioid - may be considered for pain management in fibromyalgia, but advise against use of strong opioids due to lack of evidence of efficacy, and the high risk of side effects and addiction.

2 Jun 2023

Lymphoid depletion associated with suppressed APC function characterizes the lethality of COVID-19 in mice

Individuals who are immunocompromised are considered at higher risk for severe or longer disease with COVID-19. Understanding the systemic immune response is vital for research efforts to reduce its effects on multiple organs.

2 Jun 2023

Eye drops to slow the progression of nearsightedness in kids could be on the horizon

The results of a new clinical trial suggest that the first drug therapy to slow the progression of nearsightedness in kids could be on the horizon.

1 Jun 2023

Real-world management and outcomes of U.S. patients treated with BpaL for rifampin-resistant tuberculosis

Researchers reported on the treatment of rifampin-resistant tuberculosis in the United States using the FDA approved bedaquiline, pretomanid, and linezolid (BPaL) therapy.

1 Jun 2023

Novel approach improves the efficacy of immune checkpoint blockade and minimizes related side effects

Scientists at Tohoku University have discovered a novel approach that improves the efficacy of immune checkpoint blockade (ICB) - a novel form of cancer treatment utilizing immune checkpoint inhibitors (ICIs) - and minimizes the associated side effects.

1 Jun 2023

Special issue aims to deepen the conversation around cerebral palsy

Although cerebral palsy (CP) is the most common childhood-onset disability, there are very few evidence-based clinical practice guidelines or recommendations on how to treat and manage this condition.

31 May 2023

DIALIVE device may be a disease-modifying therapy for patients with acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) occurs in 30% of hospitalized cirrhosis patients, leading to over one million deaths worldwide each year.

31 May 2023

Cardiovascular comobidities in RA patients

The increased cardiovascular risks in RA include acute coronary syndromes (ACS). The extent to which DMARD-induced remission could reduce the risk of ACS in RA versus rates in the general population – and whether there are DMARD-specific beneficial effects on ACS risk – remain unknown.

31 May 2023

Innovative framework for integrating the assessment of functioning into health and social systems

The term 'well-being' entered popular vocabulary during the Covid-19 pandemic soon after 'lockdown' and 'quarantine'.

31 May 2023

Unlocking the potential of melatonin: A promising epigenetic weapon against cancer

Melatonin, a hormone derived from the pineal gland, has diverse effects on cellular processes. This review explores its potential role as an epigenetic regulator, particularly in modulating DNA methylation, and suggests its use in combination therapy as a novel anticancer strategy.

30 May 2023

Ultraflexible nanoelectrodes improve the efficacy of brain stimulation

Conventional implantable medical devices designed for brain stimulation are often too rigid and bulky for what is one of the body's softest and most delicate tissues.

30 May 2023

Verifying the healthcare, nutritional and environmental applications of new Antarctic bacteria

A scientific collaboration between the University of São Paulo (USP) in Ribeirão Preto, Brazil, and Clemente Estable Institute of Biological Research (IIBCE) in Montevideo, Uruguay, is experimenting with two new bacteria discovered in the Antarctic ten years ago, in order to verify the possibility of applications in healthcare, food processing and environmental rehabilitation.

30 May 2023

Treatment with modified lactic acid bacteria accelerates the healing of wounds, study shows

Complicated, hard-to-heal wounds are a growing medical problem and there are currently only two drugs approved with proven efficacy.

30 May 2023

NmCV-5 vaccine safety and immunogenicity against bacterial meningitis in Mali and Gambia

Researchers evaluated the safety and non-inferiority of the pentavalent meningococcal NmCV-5 vaccine.

30 May 2023

Novel technology enhances potency and breadth of vaccine-induced responses through antigen presentation

Novel EABR technology enhances potency and breadth of vaccine-induced responses through antigen presentation.

30 May 2023

New pan-cancer T cell atlas provides a deeper understanding of complex tumor microenvironment

A new study led by researchers at The University of Texas MD Anderson Cancer Center, published today in Nature Medicine, provides a deeper understanding of the vast diversity of T cell states as well as their relationships and roles within the complex tumor microenvironment, bringing a fresh perspective to understanding immunotherapy efficacy in cancer.

29 May 2023

High prevalence of galactagogue use among breastfeeding mothers in U.S.

Researchers describe the prevalence of galactagogue use among breastfeeding mothers in the United States and their perceived effects on milk production.

29 May 2023

'Every Bite Counts': The importance of monitoring diet in the first 24 months of life

Researchers address the need for improved methods of assessing dietary intake in infants and young children.

29 May 2023

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Efficacy News and Research

Study finds substantial differences in cancer drug funding decisions across high-income countries

Lupus Therapeutics announces three Phase 3 clinical trials testing new therapies for SLE and lupus nephritis

Understanding factors associated with long-term opioid use in fibromyalgia patients

Lymphoid depletion associated with suppressed APC function characterizes the lethality of COVID-19 in mice

Eye drops to slow the progression of nearsightedness in kids could be on the horizon

Real-world management and outcomes of U.S. patients treated with BpaL for rifampin-resistant tuberculosis

Novel approach improves the efficacy of immune checkpoint blockade and minimizes related side effects

Special issue aims to deepen the conversation around cerebral palsy

DIALIVE device may be a disease-modifying therapy for patients with acute-on-chronic liver failure

Cardiovascular comobidities in RA patients

Innovative framework for integrating the assessment of functioning into health and social systems

Unlocking the potential of melatonin: A promising epigenetic weapon against cancer

Ultraflexible nanoelectrodes improve the efficacy of brain stimulation

Verifying the healthcare, nutritional and environmental applications of new Antarctic bacteria

Treatment with modified lactic acid bacteria accelerates the healing of wounds, study shows

NmCV-5 vaccine safety and immunogenicity against bacterial meningitis in Mali and Gambia

Novel technology enhances potency and breadth of vaccine-induced responses through antigen presentation

New pan-cancer T cell atlas provides a deeper understanding of complex tumor microenvironment

High prevalence of galactagogue use among breastfeeding mothers in U.S.

'Every Bite Counts': The importance of monitoring diet in the first 24 months of life

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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