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New insights into lasso peptides offer promise for drug development

Lasso peptides are natural products made by bacteria. Their unusual lasso shape endows them with remarkable stability, protecting them from extreme conditions

20 Sep 2024

How plant-based, Mediterranean, and Western diets affect gut microbiota and disease

Researchers examine how different dietary components affect the gut microbiome and development of non-communicable diseases.

20 Sep 2024

Plasma pTau181 predicts Alzheimer’s progression in real-world memory clinic patients

Researchers confirm plasma pTau181 is a strong predictor for Alzheimer's in patients with mild cognitive impairment, offering a less invasive diagnostic tool for early intervention.

20 Sep 2024

Janus particles enable highly precise measurements in microfluidic devices

The importance of testing for diseases was thrust into the limelight during the COVID-19 pandemic. Many of us have undergone a PCR (Polymerase Chain Reaction) or ELISA (Enzyme-Linked Immunosorbent Assay) test within the past four years.

20 Sep 2024

Cellular sludge around hunger neurons linked to worsening diabetes and obesity

Investigating ECM changes in the hypothalamus reveals mechanisms behind insulin resistance, offering insights into obesity and metabolic disease treatment.

19 Sep 2024

Cardiovascular disease pathways associated with psoriasis, but not other immune-mediated diseases

A genetic connection between cardiovascular disease and psoriasis highlights shared inflammatory pathways, emphasizing the need for cardiovascular monitoring.

19 Sep 2024

Leptin variations may influence brain health and dementia development

New research is more closely linking obesity to dementia. Higher levels of leptin, a hormone that helps maintain normal body weight, is associated with better signal-transmitting brain white matter in middle-aged adults, according to a study by The University of Texas Health Science Center at San Antonio (UT Health San Antonio).

18 Sep 2024

Study explores microglial response to chronic hyponatremia and rapid sodium correction

Low serum sodium concentrations in blood are called hyponatremia, a prevalent clinical electrolyte disorder.

18 Sep 2024

A novel approach to biomolecule engineering

Thanks to a serendipitous discovery and a lot of painstaking work, scientists can now build biohybrid molecules that combine the homing powers of DNA with the broad functional repertoire of proteins -; without having to synthesize them one by one, researchers report in a new study. Using a naturally occurring process, laboratories can harness the existing molecule-building capacities of bacteria to generate vast libraries of potentially therapeutic DNA-protein hybrid molecules.

18 Sep 2024

Ohio State's novel DHODH inhibitor enters first human trials

A new therapeutic agent discovered and developed at The Ohio State University will soon be used for cancer treatment at the patient's bedside as part of a clinical trial.

17 Sep 2024

Discovery of gene variant could transform treatment for newborn jaundice

One in eight newborn babies has a gene variant that almost completely protects against jaundice. The research, conducted at the University of Gothenburg in Sweden, provides the opportunity to develop a treatment that can prevent severe cases of jaundice.

17 Sep 2024

How nutrition and telomere dynamics shape beauty and aging in women

Research explores the intricate relationship between health, beauty, and aging in women, emphasizing the critical roles of telomere dynamics and nutrition in promoting longevity and vitality.

17 Sep 2024

How stress reduces sperm motility by altering mitochondria

Researchers investigate the effects of perceived stress on sperm motility and maturation.

16 Sep 2024

Cardiovascular risks of COVID-19 antivirals

Study reviews cardiovascular side effects linked to antiviral therapies for COVID-19, highlighting the need for careful consideration when prescribing these drugs to high-risk patients.

16 Sep 2024

Key enzyme identified as potential target for cancer treatment

During every moment of any living organism's life, enzymes are at work. These crucial proteins support life through most biological processes, including metabolism, movement, respiration, and digestion.

14 Sep 2024

GLP-2 regulates appetite by influencing gut-brain communication and gastrointestinal motility

Researchers examine the role of GLP-2 in regulating food intake through its effects on gastrointestinal motility and satiety signals, offering insights into potential obesity treatments.

12 Sep 2024

COVID-19 reduces male fertility by affecting semen quality and hormone levels

Study reveals that SARS-CoV-2 significantly impairs male fertility by reducing semen quality and altering reproductive hormone levels, with partial recovery post-treatment.

11 Sep 2024

Disrupted glucose transport in oligodendrocytes linked to myelin thinning and aging in new research

This study uncovers how oligodendroglial lipid metabolism supports myelin homeostasis and axonal function under metabolic stress, crucial for neurodegeneration.

11 Sep 2024

New target identified for potential ALS therapy

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects motor neurons.

10 Sep 2024

Sulthiame shows promise in reducing obstructive sleep apnea symptoms

Patients taking sulthiame, a drug currently in use for epilepsy, experienced a reduction in their symptoms of obstructive sleep apnoea (OSA), according to results of a clinical trial presented at the European Respiratory Society (ERS) Congress in Vienna, Austria.

10 Sep 2024