Enzyme News and Research

RSS

Brazil Scientific Motility Society awards training grant to GHSU’s Department of Physiology

The Department of Physiology at the Medical College of Georgia at Georgia Health Sciences University has been awarded a training grant from the Brazil Scientific Motility Society to advance the education of future scientists and scientific discovery.

10 Dec 2012

Targeting RAD52 protein can block the process by which leukemia stem cells repair themselves

Despite treatment with imatinib, a successful drug that targets chronic myeloid leukemia (CML), a deadly type of cancer, some patients may continue to be at risk for relapse because a tiny pool of stem cells is resistant to treatment and may even accumulate additional genetic aberrations, eventually leading to disease progression and relapse. These leukemia stem cells are full of genetic errors, loaded with potentially lethal breaks in DNA, and are in a state of constant self-repair.

10 Dec 2012

Novel organic metamaterial holds promise for drug delivery

A bit reminiscent of the Terminator T-1000, a new material created by Cornell researchers is so soft that it can flow like a liquid and then, strangely, return to its original shape.

7 Dec 2012

Scientists describe network map of genes involved in pain perception

Scientists in Australia and Austria have described a "network map" of genes involved in pain perception, with remarkable similarity from fruit flies to people. The work should help identify new analgesic drugs.

7 Dec 2012

Scientists identify novel mechanism by which ketogenic diet could delay effects of aging

Scientists at the Gladstone Institutes have identified a novel mechanism by which a type of low-carb, low-calorie diet-called a "ketogenic diet"-could delay the effects of aging. This fundamental discovery reveals how such a diet could slow the aging process and may one day allow scientists to better treat or prevent age-related diseases, including heart disease, Alzheimer's disease and many forms of cancer.

6 Dec 2012

Researchers unlock mechanisms of how the body converts dietary carbohydrates into fat

A gene that helps the body convert that big plate of holiday cookies you just polished off into fat could provide a new target for potential treatments for fatty liver disease, diabetes and obesity.

6 Dec 2012

Bisphenol A blocks calcium channels in cell membranes

Bisphenol A, a substance found in many synthetic products, is considered to be harmful, particularly, for fetuses and babies. Researchers from the University of Bonn have now shown in experiments on cells from human and mouse tissue that this environmental chemical blocks calcium channels in cell membranes. Similar effects are elicited by drugs used to treat high blood pressure and cardiac arrhythmia. The results are now presented in the journal "Molecular Pharmacology."

6 Dec 2012

Investigators describe process by which apoE4 protein promotes development of Alzheimer's

Despite researchers' best efforts, no drug exists that can slow, halt or reverse the onslaught of Alzheimer's disease. A progressive and fatal neurodegenerative disorder, Alzheimer's has stolen the memories and livelihoods of millions-leaving patients and their families struggling to cope with the disease's devastating consequences. But today, scientists at the Gladstone Institutes propose a new research avenue that has the potential to change all that.

6 Dec 2012

ASU scientists use X-ray laser to reveal 3-D structure of cathepsin B enzyme

An international team of scientists, using the world's most powerful X-ray laser, has revealed the three dimensional structure of a key enzyme that enables the single-celled parasite that causes African trypanosomiasis (or sleeping sickness) in humans.

6 Dec 2012

Tyk2 enzyme helps regulate obesity through differentiation of brown adipose tissue

Approximately 68 percent of U.S. adults are overweight or obese, according to the National Cancer Institute, which puts them at greater risk for developing cancer, cardiovascular disease, diabetes and a host of other chronic illnesses. But an international team of scientists led by Virginia Commonwealth University Massey Cancer Center researcher Andrew Larner, M.D., Ph.D., has successfully reversed obesity in mice by manipulating the production of an enzyme known as tyrosine-protein kinase-2 (Tyk2).

6 Dec 2012

University of Florida initiates enrollment in SPI-1005 Phase II trial for sensorineural hearing loss

The University of Florida (UF) has started enrolling subjects in a new study testing the oral drug developed by Sound Pharmaceuticals, Inc. (SPI-1005) to prevent hearing loss caused by loud music. Loud music or noise can induce temporary and permanent auditory threshold shifts (TTS or PTS).

6 Dec 2012

Selective targeting of neurotransmitters may allow for new medication therapies for GI conditions

Selective targeting of the neurotransmitter that differentially affects brain cells that control the two distinct functions of the pancreas may allow for new medication therapies for conditions like diabetes, dyspepsia and gastro-esophageal reflux, according to Penn State College of Medicine researchers.

5 Dec 2012

Sourdough and enzyme bioprocessing effectively modify flavor, texture of oat breads

The health-promoting properties of whole grain oat have made it a desirable ingredient for use in breads. However, the absence of gluten-forming proteins and high fibre content pose technological challenges with respect to product texture. Fundamental understanding about the role of oat components on the structure formation of dough and bread is needed to facilitate the development of new healthy variants of oat breads with consumer appealing properties.

5 Dec 2012

Researchers investigate GPER receptor as possible new drug target for breast cancer

Five-year breast cancer survival rates have improved dramatically over the past 50 years, but tumors can recur up to ten or more years after they are detected. When tumors recur, they are even more difficult to treat.

5 Dec 2012

psi-GSH prevents neurodegeneration associated with Alzheimer's in mouse model

Researchers at the University of Minnesota's Center for Drug Design have developed a synthetic compound that, in a mouse model, successfully prevents the neurodegeneration associated with Alzheimer's disease.

4 Dec 2012

New research finds bisphenol A in fetal liver tissues

New research from the University of Michigan School of Public Health found BPA, or bisphenol A, in fetal liver tissue, demonstrating that there is considerable exposure to the chemical during pregnancy.

4 Dec 2012

Merck commences MK-8931 Phase II/III trial in Alzheimer's

Merck, known as MSD outside the United States and Canada, announced it has started a Phase II/III clinical trial designed to evaluate the safety and efficacy of MK-8931 versus placebo in patients with mild-to-moderate Alzheimer's disease.

3 Dec 2012

Pain can be treated by targeting immune and nerve cells outside brain or spinal cord

The treatment of inflammatory pain can be improved by endogenous opioid peptides acting directly in injured tissue. Scientists at the Charité - Universitätsmedizin Berlin and the Université Paris Descartes showed that pain can be successfully treated by targeting immune and nerve cells outside the brain or spinal cord.

3 Dec 2012

Scientists determine how two proteins help create organelles

Scientists at The Scripps Research Institute (TSRI) have determined how two proteins help create organelles, or specialized subunits within a cell, that play a vital role in maintaining cell health. This discovery opens the door for research on substances that could interfere with the formation of these organelles and lead to new therapies for cancer.

2 Dec 2012

L-Fucose slows down and even reverses age-related skin developments

With increasing age the human skin shows a considerable loss of resistance and elasticity. These changes in skin texture, which are one of the main reasons for the appearance of wrinkles, is the age induced loss of skin thickness and the related degradation of elastin fibers within the skin. It has been proven that L-Fucose - a scarce sugar - slows down and even reverses age-related skin developments.

2 Dec 2012

Enzyme News and Research

Brazil Scientific Motility Society awards training grant to GHSU’s Department of Physiology

Targeting RAD52 protein can block the process by which leukemia stem cells repair themselves

Novel organic metamaterial holds promise for drug delivery

Scientists describe network map of genes involved in pain perception

Scientists identify novel mechanism by which ketogenic diet could delay effects of aging

Researchers unlock mechanisms of how the body converts dietary carbohydrates into fat

Bisphenol A blocks calcium channels in cell membranes

Investigators describe process by which apoE4 protein promotes development of Alzheimer's

ASU scientists use X-ray laser to reveal 3-D structure of cathepsin B enzyme

Tyk2 enzyme helps regulate obesity through differentiation of brown adipose tissue

University of Florida initiates enrollment in SPI-1005 Phase II trial for sensorineural hearing loss

Selective targeting of neurotransmitters may allow for new medication therapies for GI conditions

Sourdough and enzyme bioprocessing effectively modify flavor, texture of oat breads

Researchers investigate GPER receptor as possible new drug target for breast cancer

psi-GSH prevents neurodegeneration associated with Alzheimer's in mouse model

New research finds bisphenol A in fetal liver tissues

Merck commences MK-8931 Phase II/III trial in Alzheimer's

Pain can be treated by targeting immune and nerve cells outside brain or spinal cord

Scientists determine how two proteins help create organelles

L-Fucose slows down and even reverses age-related skin developments

Biochemistry eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest Life Science News