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Flaw in DNA helps explain cancers and aging

Their finding explains how oxidative DNA damage - a process long believed to underlie cancers and aging - can create permanent genetic damage.

30 Aug 2004

Surgery for angina in the elderly provides long-term mortality

Elderly people who undergo surgery or angioplasty to treat chest pain fare just as well long-term as those treated with medication, researchers report in Circulation: Journal of the American Heart Association.

30 Aug 2004

Common enzyme acts as a natural brake to prevent potentially deadly runaway inflammation

An enzyme found in nearly all animal and human cells acts as a natural brake to prevent potentially deadly runaway inflammation, UCSF scientists have discovered.

30 Aug 2004

Streptococcal bacteria disrupts blood clotting to infect humans

University of Michigan researchers have captured a glimpse of the endless arms race between infectious agents and the human immune system in a bacterium that uses a mimic of a human blood-clotting enzyme to advance its infection.

27 Aug 2004

Emergence of drug resistant influenza viruses more common than previously thought

Results of a small study from Japan in this week’s issue of THE LANCET suggest that the emergence of influenza viruses which are resistant to a widely used influenza drug may be more common than previously thought.

26 Aug 2004

Researchers look to make more effective drug treatments for tuberculosis

Tuberculosis isn’t yet making a major comeback in the U.S. but one- third of the world’s population is infected with the disease, and it poses a major danger to health worldwide.

26 Aug 2004

Compounds break bonds holding dangerous pollutants together

Everything from the manufacture of new materials to the creation of modern medications relies on chemicals known as metal-based catalysts. Catalysts pack a double punch: Even as they greatly increase the rate of chemical processes, they regenerate so they can be used again.

25 Aug 2004

High-resolution images reveal the molecular rearrangements that rotavirus uses to break into cells

High-resolution images constructed by researchers at Children's Hospital Boston and Harvard Medical School reveal the molecular rearrangements that rotavirus – the most common cause of severe, dehydrating diarrhea and vomiting in children worldwide – uses to break into cells.

25 Aug 2004

A new test for bowel cancer could be on the horizon

The test detects an enzyme, called Tumour M2-PK, which is a by-product of tumour growth. The enzyme leaks from the cancerous tissue into the bowel and can then be found in faeces.

25 Aug 2004

Regular exercise boosts immune system in older men

As it turns out, judging by the reaction strength of their immune system to an unknown, but harmless, protein antigen, it’s possible for men over 70 to mount an immune response similar to that produced by much younger men -- if they get regular moderate physical activity of about six hours a week.

25 Aug 2004

Scientists have uncovered a key driver behind the progression of prostate cancer

Scientists at Fred Hutchinson Cancer Research Center have uncovered a key driver behind the progression of prostate cancer, a discovery that the researchers believe could spawn new treatments to prevent the cancer's spread and extend survival.

23 Aug 2004

Researchers find how cancers, particularly lymphomas, develop and might be prevented

Researchers at Children's Hospital Boston have begun unraveling the mystery of how B lymphocytes - key infection-fighting cells in the body - are able to create many different kinds of specialized antibodies through selective gene mutations, while being protected from random mutations that could give rise to cancers.

23 Aug 2004

Computer model of damaged DNA bends the rules

Our knees may become stiff when injured, but banged up DNA becomes flexible, suggests the most detailed computer model of damaged DNA to date. Further, this flexibility explains how the body's enzymes recognize and fix damaged DNA.

23 Aug 2004

First whole-genome survey of where three commonly used retroviruses into human DNA

Retroviruses are one of the most common vehicles for delivering therapeutic payloads via gene therapy in animal models of disease and human patients.

22 Aug 2004

Existing hepatitis drug could lead to the development of new drugs for the treatment of anthrax

Thanks to new screening tools, and some luck, researchers at the University of Chicago have discovered three unrelated compounds that inhibit the two toxins – edema factor and lethal factor -- that have made anthrax one of the most feared of potential bioterror agents.

21 Aug 2004

Enzyme activation key to body clock

Feel like time is repeating itself and won’t move on? It could be your internal clock is backpedaling because your PKG-II is out of whack.

20 Aug 2004

Scientists have developed the first mouse model Werner’s syndrome

Scientists have developed the first mouse model of a rare disease in which people age rapidly and start developing cancers and other diseases associated with the elderly when they are only about 30 years old.

20 Aug 2004

FDA fast tracks temsirolimus, first-line treatment of poor-prognosis patients with advanced renal cell carcinoma

Wyeth Pharmaceuticals has announced that the U.S. Food and Drug Administration has granted a new "fast track" designation for temsirolimus (CCI-779), an investigational mTOR kinase inhibitor, in the first-line treatment of poor-prognosis patients with advanced renal cell carcinoma (RCC).

18 Aug 2004

Large-scale computer simulations help understand SARS

A Mayo Clinic researcher is the first to develop a series of three-dimensional (3D) models of an enzyme responsible for the replication of the deadly SARS (Severe Acute Respiratory syndrome) virus.

17 Aug 2004

Scientists visualise protein complex responsible for looking after out of shape proteins

The structure of the chaperonin complex of the bacteria Thermus thermophilus reveals clues about how the important molecule may do its job of folding new or damaged proteins within cells.

17 Aug 2004

Enzyme News and Research

Flaw in DNA helps explain cancers and aging

Surgery for angina in the elderly provides long-term mortality

Common enzyme acts as a natural brake to prevent potentially deadly runaway inflammation

Streptococcal bacteria disrupts blood clotting to infect humans

Emergence of drug resistant influenza viruses more common than previously thought

Researchers look to make more effective drug treatments for tuberculosis

Compounds break bonds holding dangerous pollutants together

High-resolution images reveal the molecular rearrangements that rotavirus uses to break into cells

A new test for bowel cancer could be on the horizon

Regular exercise boosts immune system in older men

Scientists have uncovered a key driver behind the progression of prostate cancer

Researchers find how cancers, particularly lymphomas, develop and might be prevented

Computer model of damaged DNA bends the rules

First whole-genome survey of where three commonly used retroviruses into human DNA

Existing hepatitis drug could lead to the development of new drugs for the treatment of anthrax

Enzyme activation key to body clock

Scientists have developed the first mouse model Werner’s syndrome

FDA fast tracks temsirolimus, first-line treatment of poor-prognosis patients with advanced renal cell carcinoma

Large-scale computer simulations help understand SARS

Scientists visualise protein complex responsible for looking after out of shape proteins

Biochemistry eBook

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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