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Not all good cholesterol helps to protect arteries from becoming clogged with fatty deposits

HDL becomes dysfunctional, Dr. Hazen said, when myeloperoxidase (MPO), an enzyme present in white blood cells, inhibits the HDL's ability to keep LDL, or "bad" cholesterol, from building up in artery walls.

17 Aug 2004

Cell biologists may have discovered a new effective therapy for psoriasis

About two million Germans suffer from psoriasis (from the Greek psora meaning ‘itching, scratching’). In this incurable disease the regeneration of the epidermis is speeded up enormously: whereas it normally renews itself in just under four weeks, this period is cut to four to seven days in psoriasis patients.

16 Aug 2004

New imaging technique may help cystic fibrosis sufferers

Now, Jefferson Lab scientists have used their expertise to build a small animal medical imager that's helping researchers develop a new gene therapy technique for cystic fibrosis.

15 Aug 2004

Pineal gland which regulates the cycles of sleep and waking evolved to improve vision

The pineal gland - which regulates the cycles of sleep and waking - appears to have evolved as an indirect way to improve vision, by keeping toxic compounds away from the eye

13 Aug 2004

Important for physicians to identify patients at risk for hyperkalemia and implement corresponding measures when using ACE inhibitors

Some patients with hypertension or other cardiovascular diseases should be closely monitored in order to maintain safe potassium levels in the body when prescribed certain medications, counsels a nephrologist at UT Southwestern Medical Center at Dallas.

11 Aug 2004

Signet Laboratories has announced the release of ACUITY mouse-on-mouse polymer detection system

Signet's ACUITY(TM) Mouse-on-Mouse Polymer Detection System is a sensitive biotin-free detection system for use with monoclonal and polyclonal antibodies on mouse or rat tissue. ACUITY(TM) Mouse-on-Mouse provides cost savings by enabling researchers to use less antibody, while increasing staining intensity and eliminating background.

9 Aug 2004

New direction for research into Sly Syndrome

Findings by a Saint Louis University research team led by the scientist who discovered Sly Syndrome 32 years ago point to a new direction for research into the rare genetic disorder that can cause bone deformities, vision and hearing loss, mental retardation and death in children.

9 Aug 2004

Austrian researchers in a world first have successfully engineered an allergy vaccine

Austrian researchers in a world first have successfully engineered an allergy vaccine using a genetically modified version of the birch pollen allergen.

9 Aug 2004

Nogo protein may control the progression of Alzheimer’s disease

Researchers in the Department of Neurosciences at The Cleveland Clinic Lerner Research Institute have found that Nogo, a protein known for its ability to regulate nerve regeneration, may control the progression of Alzheimer’s disease.

3 Aug 2004

Water from the Dead Sea, the climate of Jordan and a special cream can significantly help sufferers of vitiligo

Vitiligo causes the skin to lose its colour in patches and is associated with a build-up of an oxygen-related molecule (hydrogen peroxide) in the skin. Sufferers can't fight the development of this molecule due to a shortage of an enzyme in the skin.

3 Aug 2004

Third of heart failure patients face increased risk of death because they do not receive an angiotensin-converting enzyme (ACE) inhibitor

Overwhelming evidence accumulated during almost 20 years of clinical experience has established the benefits of this drug, which blocks the harmful effects of angiotensin, a substance that causes blood vessels to narrow, said the study authors.

3 Aug 2004

Metabasis Therapeutics announces multi-center Phase 2 study to evaluate the orally administered antiviral compound remofovir mesylate

Metabasis Therapeutics has announced the initiation of a multi-center, multi- national Phase 2 study to evaluate the orally administered antiviral compound remofovir mesylate in chronic hepatitis B (HBV) infected patients.

3 Aug 2004

Switches in the brain that tell the body to stop eating and start burning calories

A Brown-led research team has discovered a pair of universal switches in the brain that tell the body to stop eating and start burning calories.

3 Aug 2004

First-of-its-kind noninvasive imaging technique shows two proteins interacting

Radiologists at Washington University School of Medicine in St. Louis have developed a first-of-its-kind noninvasive imaging technique that allows them to watch two proteins interacting in live animals.

2 Aug 2004

Scientists create mice that don't gain weight, even when fed fat-laden, high calorie diets

By altering the expression of a single -- albeit different – gene, Drs. Roger Davis (UMASS Medical School, USA) and Ying-Hue Lee (Academia Sinica, Taiwan) have succeeded in creating two different strains of transgenic mice that don't gain weight, even when fed fat-laden, high calorie diets.

2 Aug 2004

Identification of PIK3CA as an oncogene associated with brain cancers opens the door to new screening processes

Hotspots in two areas of a gene that encodes a specific signaling enzyme, or kinase, are vulnerable to a variety of mutations found in five types of brain cancers, according to a report published in the August 1 issue of the journal Cancer Research.

2 Aug 2004

Anti-hypertensive drug clonidine before non-cardiac surgery reduces risk of complications due to inadequate blood flow to the heart

Patients with or at risk for heart disease who take the anti-hypertensive drug clonidine before non-cardiac surgery can significantly reduce the risk of complications and death due to inadequate blood flow to the heart, according to a study by UCSF researchers at the San Francisco Veterans Affairs Medical Center.

29 Jul 2004

Adenosine triphosphate is a culprit in causing the devastating damage of spinal cord injury

ATP - adenosine triphosphate, the vital energy source that keeps our body’s cells alive, runs amok at the site of a spinal cord injury, pouring into the area around the wound and killing the cells that normally allow us to move, scientists report in the cover story of the August issue of Nature Medicine.

29 Jul 2004

Molecular pathway in the brain may explain why some patients suffering from inflammatory diseases develop depression

Feeling sick can be "all in the head" for people with inflammatory disorders or for those receiving immunotherapy, say Robert Dantzer and Keith Kelley, professors in the department of animal sciences at the University of Illinois at Urbana-Champaign.

29 Jul 2004

Proof of principle that it is possible to deliver new genes body-wide to all the muscles of an adult animal

MDA-supported researchers at the University of Washington-Seattle have delivered the gene for the dystrophin protein to all voluntary muscles with a single intravenous injection in mice with Duchenne muscular dystrophy (DMD).

29 Jul 2004

Enzyme News and Research

Not all good cholesterol helps to protect arteries from becoming clogged with fatty deposits

Cell biologists may have discovered a new effective therapy for psoriasis

New imaging technique may help cystic fibrosis sufferers

Pineal gland which regulates the cycles of sleep and waking evolved to improve vision

Important for physicians to identify patients at risk for hyperkalemia and implement corresponding measures when using ACE inhibitors

Signet Laboratories has announced the release of ACUITY mouse-on-mouse polymer detection system

New direction for research into Sly Syndrome

Austrian researchers in a world first have successfully engineered an allergy vaccine

Nogo protein may control the progression of Alzheimer’s disease

Water from the Dead Sea, the climate of Jordan and a special cream can significantly help sufferers of vitiligo

Third of heart failure patients face increased risk of death because they do not receive an angiotensin-converting enzyme (ACE) inhibitor

Metabasis Therapeutics announces multi-center Phase 2 study to evaluate the orally administered antiviral compound remofovir mesylate

Switches in the brain that tell the body to stop eating and start burning calories

First-of-its-kind noninvasive imaging technique shows two proteins interacting

Scientists create mice that don't gain weight, even when fed fat-laden, high calorie diets

Identification of PIK3CA as an oncogene associated with brain cancers opens the door to new screening processes

Anti-hypertensive drug clonidine before non-cardiac surgery reduces risk of complications due to inadequate blood flow to the heart

Adenosine triphosphate is a culprit in causing the devastating damage of spinal cord injury

Molecular pathway in the brain may explain why some patients suffering from inflammatory diseases develop depression

Proof of principle that it is possible to deliver new genes body-wide to all the muscles of an adult animal

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Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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