Signet Laboratories has announced the release of ACUITY mouse-on-mouse polymer detection system

Signet Laboratories has announced the release of ACUITY(TM) Mouse-on-Mouse Polymer Detection System.

ACUITY(TM) Mouse-on-Mouse is sensitive enough to allow researchers to use mouse monoclonal antibodies on mouse or rat tissue.

Signet's ACUITY(TM) Mouse-on-Mouse Polymer Detection System is a sensitive biotin-free detection system for use with monoclonal and polyclonal antibodies on mouse or rat tissue. ACUITY(TM) Mouse-on-Mouse provides cost savings by enabling researchers to use less antibody, while increasing staining intensity and eliminating background.

According to Angela Thomas, IHC Product Manager for Signet Laboratories, "ACUITY(TM) Mouse-on-Mouse eliminates non-specific staining through the use of Signet's proprietary blocking reagent system, allowing researchers to use readily available antibodies rather than costly esoteric antibodies from different species."

ACUITY(TM) kits are intended for the chromogenic detection of antigens that have bound to a user-supplied primary antibody on mouse or rat tissue. ACUITY(TM) Mouse-on-Mouse utilizes a combination of novel poly-labeling and blocking technologies. Secondary antibodies are directly polymerized with horseradish peroxidase (HRP) or Alkaline Phosphatase (AP) into compact polymers bearing a higher ratio of enzymes to antibodies. The novel blocking technology eliminates background staining and provides sensitive and specific detection of antigens on mouse or rat tissues with mouse or rabbit primary antibodies.

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